Article
Biochemistry & Molecular Biology
Wangsheng Jiang, Wenfeng Ruan, Zhengqiang Wang
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can alleviate vascular calcification in patients with chronic kidney disease (CKD) by suppressing inflammation and apoptosis through the activation of heme oxygenase-1 (HMOX-1). These results provide a promising treatment approach for vascular calcification in CKD.
Article
Urology & Nephrology
Hironari Hanaoka, Jun Kikuchi, Kazuoto Hiramoto, Shuntaro Saito, Yasushi Kondo, Yuko Kaneko
Summary: This study investigated the incidence and factors associated with the progression of chronic kidney disease (CKD) in patients with stable rheumatoid arthritis (RA). The results showed that controlling inflammation contributes to inhibiting CKD progression in RA patients.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jiao Li, Jiani Wang, Ziqian Huang, Xiaodong Cui, Chen Li
Summary: In this study, QUE oxidation product (QUE-ox) was prepared through enzymatic oxidation of QUE. The oxidation reduced the antioxidant activity of QUE but increased its anti-amyloid activity in vitro. In C. elegans, oxidation increased the anti-aging effects of QUE.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xinling Song, Hui Pang, Weijun Cui, Jianjun Zhang, Jian Li, Le Jia
Summary: Enzymatic-hydrolyzed Auricularia polytricha polysaccharides (EnAPS) demonstrated superior renal protection through antioxidant and anti-inflammatory effects, as well as proven anti-apoptosis and anti-fibrosis effects. Lower molecular weights may contribute to the enhanced renoprotective effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Paul M. Ridker, Katherine R. Tuttle, Vlado Perkovic, Peter Libby, Jean G. MacFadyen
Summary: This study found that residual inflammatory risk plays a significant role in determining the risk of recurrent major adverse cardiovascular events among post-myocardial infarction patients already treated with statins, especially in those with impaired kidney function.
EUROPEAN HEART JOURNAL
(2022)
Article
Immunology
Zahra Tavakoli, Hossein Tahmasebi Dehkordi, Zahra Lorigooini, Mohammad Rahimi-Madiseh, Mehrdad Shahrani Korani, Hossein Amini-Khoei
Summary: This study aimed to evaluate the effect of quercetin on PTZ-induced seizures in mice and focus on its potential anti-neuroinflammatory and anti-oxidative stress properties. The results showed that quercetin increased the seizure threshold, enhanced total antioxidant capacity, and reduced levels of malondialdehyde as well as the expression of inflammatory genes in the prefrontal cortex.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jessica Freitas Araujo Encinas, Carlos Henrique Foncesca Peiro, Matheus Moreira Perez, Joyce Regina Santos Raimundo, Katharyna Cardoso de Gois, Marina Cristina Peres, Patricia Ferrante Draghi, Catherine Giovanna Costas Arcia, Diogo Pimenta Simoes, Neif Murad, Beatriz da Costa Aguiar Alves, Fernando Luiz Affonso Fonseca, Glaucia Luciano da Veiga
Summary: NEB is a drug used for the treatment of systemic arterial hypertension, with potential additional effects such as antioxidant and renal protection. The aim of this study was to investigate the impact of NEB on kidney diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Review
Biochemistry & Molecular Biology
Susana Coimbra, Susana Rocha, Maria Joao Valente, Cristina Catarino, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Chronic kidney disease is often accompanied by multiple comorbidities and poor clinical outcomes. Malnutrition-inflammation-atherosclerosis syndrome is common in severe stages of CKD, and adiponectin and leptin may be associated with the risk of cardiovascular disease events.
Article
Biochemistry & Molecular Biology
Sang Gu Kang, Gi Baek Lee, Ramachandran Vinayagam, Geum Sook Do, Se Yong Oh, Su Jin Yang, Jun Bum Kwon, Mahendra Singh
Summary: Quercetin (Qu), a plant polyphenol, can improve bioavailability in nanosuspensions, exhibiting antioxidant, anti-inflammatory, and antibacterial effects.
Review
Biochemistry & Molecular Biology
Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang
Summary: This review summarizes the function and beneficial properties of common flavonoids for the treatment of CKD and renal fibrosis, including preventing renal dysfunction and improving renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation.
Review
Biochemistry & Molecular Biology
Felix Zulhendri, Munir Ravalia, Krishna Kripal, Kavita Chandrasekaran, James Fearnley, Conrad O. Perera
Summary: Propolis, collected by bees from plants, has been used therapeutically for centuries and may have potential in ameliorating the symptoms of metabolic syndrome (MetS) and its associated chronic diseases. This review article aims to comprehensively analyze the therapeutic benefits of propolis, focusing on its antioxidant and anti-inflammatory properties in inhibiting the development and manifestation of MetS and its chronic diseases.
Article
Biochemistry & Molecular Biology
Donghua Jin, Lihua Lin, Yuxian Xie, Miao Jia, Hong Qiu, Kang Xun
Summary: Vascular calcification (VC), a common complication of chronic kidney disease (CKD), can be prevented by the activation of the antioxidant NRF2 pathway. This study found that NRF2 activation can suppress osteogenic transition and apoptosis in vascular smooth muscle cells (VSMCs), indicating its potential as a therapeutic treatment for CKD-associated VC.
Article
Urology & Nephrology
Violante Olivari, Simona Maria Di Modica, Maria Rosa Lidonnici, Mariam Aghajan, Celia Cordero-Sanchez, Emanuele Tanzi, Mariateresa Pettinato, Alessia Pagani, Francesca Tiboni, Laura Silvestri, Shuling Guo, Giuliana Ferrari, Antonella Nai
Summary: Anemia, a common complication of systemic inflammation, is influenced by cytokines, hepatic hormone, and iron metabolism. Anemia of chronic kidney disease (CKD) is a distinct form of inflammatory anemia, and traditional therapy based on increased erythropoietin (EPO) is limited. Hematopoietic and hepatic targeting of transferrin receptor 2 (Tfr2) can improve anemia by promoting erythropoiesis and increasing iron supply. Thus, combined targeting of hematopoietic and hepatic Tfr2 may be a potential therapeutic option.
KIDNEY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Yue Gong, Hong Xu Li, Rui Hong Guo, Wahyu Widowati, Young Ho Kim, Seo Young Yang, Young Ran Kim
Summary: Compound 1 from P. crocatum leaves is identified as an active anti-allergic inflammatory component, showing potent suppression of NO production and beta-hexosaminidase release.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Muhamad Sahlan, Kaysa Faradis Mahira, Diah Kartika Pratami, Rizal Rizal, Mohammad Javed Ansari, Khalid Mashay Al-Anazi, Mohammad Abul Farah
Summary: Indonesian propolis from Tetragonula sapiens possesses immunomodulatory properties, exhibiting anti-inflammatory effects and cytotoxicity against cells. The study revealed that it inhibits the production of nitric oxide by macrophages, indicating its potential as an anti-inflammatory agent.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Meilinah Hidayat, Sijani Prahastuti, Ervi Afifah, Wahyu Widowati, Muhammad Yusuf, Khomaini Hasan
Summary: The study showed that PHGPB and LERGDT have anti-fibrotic effects on renal fibrosis by reducing TGF-beta 1 levels and SMAD gene expression, suggesting their potential as therapeutic options for improving renal function in fibrosis.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Wahyu Widowati, Sijani Prahastuti, Meilinah Hidayat, Stella Tinia Hasianna, Roro Wahyudianingsih, The Fransiska Eltania, Alya Mardhotillah Azizah, Jenifer Kiem Aviani, Mawar Subangkit, Rr Anisa Siwianti Handayani, Hanna Sari Widya Kusuma
Summary: The study showed that treatment with ethanol extract of black soybean successfully reduced pro-inflammatory cytokines IL-1β and IFN-γ, improved physiological condition by lowering BUN and UA content, and increasing CAT activity. No significant effect was found in Casp-3 expression. EEBS has the potential to improve acute renal failure condition through inflammatory suppression and renal function improvement.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Dian Ratih Laksmitawati, Siti Umrah Noor, Yati Sumiyati, Adrian Hartanto, Wahyu Widowati, Diah Kartika Pratami
Summary: This study investigated the activity of mesenchymal stem cell-conditioned medium gel in healing and repairing third-degree burns on rat skin. The results showed that the gel had better wound healing and faster hair growth compared to other treatments.
Article
Medicine, Research & Experimental
Dian Ratih Laksmitawati, Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Hanna Sari Widya Kusuma, Ervi Afifah, Ratih Rinendyaputri, Rilianawati Rilianawati, Ahmad Faried, Ni Ketut Susilarini
Summary: This study found that the production of inflammatory modulators varied in CM-ATMSC treated with fresh frozen plasma at different passages. IL-6 was identified as the most potent proinflammatory modulator among the factors measured.
MEDICAL SCIENCE MONITOR BASIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Wahyu Widowati, Lusiana Darsono, Johan Lucianus, Edwin Setiabudi, Selonan Susang Obeng, Shiela Stefani, Roro Wahyudianingsih, Kaleb Reynaldo Tandibua, Richard Gunawan, Cahyaning Riski Wijayanti, Agung Novianto, Hanna Sari Widya Kusuma, Rizal Rizal
Summary: The study found that butterfly pea flower extract (CTE) has antioxidant and anti-inflammatory effects, which can improve the pathological conditions of diabetes and dyslipidemia in rats, reduce blood glucose levels, increase insulin levels, and has the potential for diabetes treatment.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, General & Internal
Wahyu Widowati, Teresa L. Wargasetia, Fanny Rahardja, Rimonta F. Gunanegara, Didik Priyandoko, Marisca E. Gondokesumo, Agung Novianto, Afif Yati, Rizal Rizal
Summary: This study found that co-culture of hWJMSCs and L2 cells could mitigate inflammation and apoptosis by regulating gene expression and protein levels, protecting the lung from injury.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Veterinary Sciences
Wahyu Widowati, Sijani Prahastuti, Meilinah Hidayat, Stella Tinia Hasiana, Roro Wahyudianingsih, Ervi Afifah, Hanna Sari Widya Kusuma, Rizal Rizal, Mawar Subangkit, Jati Belanda
Summary: This study investigated the protective effect of the ethanolic extract of Guazuma ulmifolia leaves in cisplatin-induced nephrotoxic rats and found that it could reduce oxidative stress levels and immune-inflammatory response. However, further research is needed to evaluate its toxicity effects and conduct clinical trials.
PAKISTAN VETERINARY JOURNAL
(2022)
Article
Medicine, General & Internal
Wahyu Widowati, Teresa Liliana Wargasetia, Teddy Marcus Zakaria, Michael Sebastian Gunadi, Nathanael Halim, Nindia Salsabila Mia Dewi, Sherly Santiadi, Sherly Santiadi
Summary: This study investigated the antioxidant activities of JaTe herbal tea made from dried ginger and telang flower, and found that it exhibited strong antioxidant properties with high scavenging activities against DPPH, ABTS, and H2O2.
MAJALAH KEDOKTERAN BANDUNG
(2022)
Article
Tropical Medicine
Wahyu Widowati, Teresa Liliana Wargasetia, Fanny Rahardja, Rimonta Gunanegara, Didik Priyandoko, Marisca Evalina Gondokesumo, Ervi Afifah, Cahyaning Riski Wijayanti, Rizal Rizal
Summary: This study evaluated the potential effect of human Wharton's jelly mesenchymal stem cells (hWJMSCs) on acute respiratory distress syndrome in a rat model. The results showed that hWJMSCs could decrease inflammatory markers and may be further investigated for the treatment of acute respiratory distress syndrome.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2022)