☆ 4.2 Article

1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia-A prospective observational study

NPJ PRIMARY CARE RESPIRATORY MEDICINE (2022)

Journal

NPJ PRIMARY CARE RESPIRATORY MEDICINE

Volume 32, Issue 1, Pages -

Publisher

NATURE PORTFOLIO

DOI: 10.1038/s41533-022-00273-z

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Funding

Ricerca e Innovazione (AFRI) EOC (FONDO ricerca COVID19 AFRI) [SOC 509.99001]

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Abstract

This study observed the condition of patients with SARS-CoV-2 pneumonia one year later and found that most patients still had abnormalities in radiological and functional aspects, and a decrease in health-related quality of life, despite showing progressive recovery.

All over the world, SARS-CoV-2 pneumonia is causing a significant short and medium-term morbidity and mortality, with reported persisting symptoms, radiological and lung alterations up to 6 months after symptoms onset. Nevertheless, the 1-year impact on affected patients is still poorly known. In this prospective observational study, 39 patients with SARS-CoV-2 pneumonia were recruited from a single COVID-19 hospital in Southern Switzerland. They underwent a 3-month and 1-year follow-ups. At 1 year, 38 patients underwent functional follow-up through lung function tests and six minutes walking test and submitted SF-12 and SGRQ questionnaires about health-related quality of life. At 1 year most of the patients showed a persistence of the radiological and functional abnormalities and a reduction of the health-related quality of life. Thirty patients (96.8%) still presented some residual abnormalities on CT scans (31 patients at 3 months), though with a general reduction of the lesional load in all lung lobes. Twenty patients (52.6%) had persisting lung function tests impairment, with an overall improvement of DLCO. As concerning the functional status, lowest SpO2 during 6MWT increased significantly. Finally, 19 patients (50%) reported a pathological St. George's Respiratory Questionnaire, and respectively 12 (31.6%) and 11 (28.9%) patients a pathological Short Form Survey-12 in physical and mental components. At 1-year follow-up SARS-CoV-2 pneumonia survivors still present a substantial impairment in radiological and functional findings and in health-related quality of life, despite showing a progressive recovery.

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The Presence of Either Typical or Atypical Radiological Changes Predicts Poor COVID-19 Outcomes in HIV-Positive Patients from a Multinational Observational Study: Data from Euroguidelines in Central and Eastern Europe Network Group

Justyna D. Kowalska, Carlo Bienkowski, Lukas Fleischhans, Sergii Antoniak, Agata Skrzat-Klapaczynska, Magdalena Suchacz, Nikolina Bogdanic, Deniz Gokengin, Cristiana Oprea, Igor Karpov, Kerstin Kase, Raimonda Matulionyte, Antonios Papadopoulos, Nino Rukhadze, Arjan Harxhi, David Jilich, Botond Lakatos, Dalibor Sedlacek, Gordana Dragovic, Marta Vasylyev, Antonia Verhaz, Nina Yancheva, Josip Begovac, Andrzej Horban

Summary: This study aims to investigate the association between radiological changes and poor COVID-19 outcomes among HIV-positive patients. Through collecting observational data from Central and Eastern Europe, the study found that radiological COVID-19 changes can independently predict poorer outcomes in HIV patients.

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