Journal
CLINICAL INTERVENTIONS IN AGING
Volume 17, Issue -, Pages 405-415Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S349604
Keywords
aging; osteoporosis; bone formation; epigenetics; autophagy; chlorine channel
Categories
Funding
- National Natural Science Foundation of China [81800785, 81972085, 81902303]
- Natural Science Foundation of Guangdong Province [2018A0303100027, 2020A151501048]
- Medical Science and Technology Research Foundation of Guangdong Province [A2018262]
- Sanming Project of Shenzhen Health and Family Planning Commission [SZSM201612086]
- Shenzhen Science and Technology Planning [JCYJ20180228163401333, JCYJ20190806170612680, JCYJ20190806164216661, RCBS20200714114856299]
- Doctor Innovation Project of Shenzhen Health System [SZBC2018015]
- Shenzhen Peacock Project [KQTD20170331100838136]
- Shenzhen Key Medical Discipline Construction Fund [SZXK025]
- discipline construction Capacity Improvement project of Shenzhen Municipal Health Commission [SZXJ2018065]
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The study summarizes the impact of aging on bone remodeling and the mechanisms of osteoporosis, including the role of ion channels. It also summarizes the current clinical medications and treatment targets for osteoporosis.
Senescence mainly manifests as a series of degenerative changes in the morphological structure and function of the body. Osteoporosis is a systemic bone metabolic disease characterized by destruction of bone microstructure, low bone mineral content, decreased bone strength, and increased brittleness and fracture susceptibility. Osteoblasts, osteoclasts and osteocytes are the main cellular components of bones. However, in the process of aging, due to various self or environmental factors, the body's function and metabolism are disordered, and osteoporosis will appear in the bones. Here, we summarize the mechanism of aging, and focus on the impact of aging on bone remodeling homeostasis, including the mechanism of ion channels on bone remodeling. Finally, we summarized the current clinical medications, targets and defects for the treatment of osteoporosis.
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