Article
Respiratory System
Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Eva Alsheimer, Ralf Ewert, George Giannakoulas, Lukas Hobohm, Karsten Keller, Anna C. Mavromanoli, Stephan Rosenkranz, Timothy A. Morris, Stavros V. Konstantinides, Matthias Held, Daniel Dumitrescu
Summary: This study investigated the association between exercise limitation assessed by cardiopulmonary exercise testing (CPET) and clinical, echocardiographic, laboratory abnormalities, and quality of life (QoL) after pulmonary embolism (PE). The results showed that abnormal exercise capacity of cardiopulmonary origin is common after PE and is associated with clinical and haemodynamic impairment, as well as long-term QoL reduction. CPET can be considered for selected patients with persisting symptoms after PE to identify candidates for closer follow-up and possible therapeutic interventions.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Thomas Jack, Julia Carlens, Franziska Diekmann, Hosan Hasan, Philippe Chouvarine, Nicolaus Schwerk, Carsten Mueller, Ivonne Wieland, Igor Tudorache, Gregor Warnecke, Murat Avsar, Alexander Horke, Fabio Ius, Dmitry Bobylev, Georg Hansmann
Summary: A prospective observational study at Hannover Medical School showed that lung transplantation (LuTx) in children with end-stage pulmonary arterial hypertension (PAH) resulted in excellent midterm outcomes with 100% survival at 2 years post-LuTx. Postoperative VA-ECMO support facilitated early extubation and contributed to sustained biventricular reverse-remodeling and improved systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Silvia Papa, Cristiano Miotti, Giovanna Manzi, Gianmarco Scoccia, Federico Luongo, Federica Toto, Claudia Malerba, Nadia Cedrone, Elena Sofia Canuti, Annalisa Caputo, Giulia Manguso, Serena Valentini, Susanna Sciomer, Francesco Ciciarello, Giulia Benedetti, Francesco Fedele, Carmine Dario Vizza, Roberto Badagliacca
Summary: This study found that CAVI may serve as an early marker for chronic thromboembolic pulmonary hypertension (CTEPH). The CAVI value is significantly correlated with the echocardiographic probability of PH in patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Kim M. Kerr, C. Greg Elliott, Kelly Chin, Raymond L. Benza, Richard N. Channick, R. Duane Davis, Feng He, Andrea LaCroix, Michael M. Madani, Vallerie V. McLaughlin, Myung Park, Ivan M. Robbins, Victor F. Tapson, Jeffrey R. Terry, Victor J. Test, Sonia Jain, William R. Auger
Summary: The US-CTEPH-R aimed to characterize patients with chronic thromboembolic pulmonary hypertension and outcomes of surgical and nonsurgical therapies. Differences were found between operated and nonoperated patients, with the most favorable 1-year outcomes in patients who underwent pulmonary thromboendarterectomy surgery.
Article
Pediatrics
Marilena Savoia, Francesca Rech Morassutti, Luigi Castriotta, Daisy Pavoni, Peter M. Mourani, Paola Freschi, Luigi Cattarossi, Antonio Tonutti
Summary: This study evaluated the feasibility of using neonatologist-performed echocardiography for follow-up of preterm infants with moderate/severe bronchopulmonary dysplasia (BPD) and described the course of pulmonary hypertension (PH) in these infants. NPE follow-up was found to be safe for infants with BPD, aiding in early detection of mild PH.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Immunology
Manuel Rubio-Rivas, Narcis A. Homs, Daniel Cuartero, Xavier Corbella
Summary: The overall PAH prevalence found was 6.4% (95%CI 5%-8.3%) and the overall PAH incidence 18.2 cases per 1000 person-years (95%CI 12-27.4). Studies on lcSSc and dcSSc showed different prevalence rates, with lcSSc at 7.7% (95% CI 5.3%-11.1%) and dcSSc at 6.3% (95% CI 4.5%-8.9%). Overall, the incidence of PAH in SSc patients was found to be 18.2 cases per 1000 person-years.
AUTOIMMUNITY REVIEWS
(2021)
Article
Rheumatology
Kimberly Showalter, Laura C. Pinheiro, Deanna Jannat-Khah, Irina Sobol, Jackie Szymonifka, Jackie Finik, Virginia D. Steen, Jessica K. Gordon
Summary: This study identified predictors of hospital readmission among individuals with SSc-associated pulmonary hypertension (SSc-PH). The strongest predictor was the reason for the initial hospitalization being related to PH. Home oxygen use was associated with a lower likelihood of readmission.
Article
Respiratory System
Dieuwertje Ruigrok, M. Louis Handoko, Lilian J. Meijboom, Esther J. Nossent, Anco Boonstra, Natalia J. Braams, Jessie van Wezenbeek, Robert Tepaske, Pieter Roel Tuinman, Leo M. A. Heunks, Anton Vonk Noordegraaf, Frances S. de Man, Petr Symersky, Harm-Jan Bogaard
Summary: Residual chronic thromboembolic pulmonary hypertension (CTEPH) can be excluded after pulmonary endarterectomy (PEA) by using early post-operative haemodynamics, N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiopulmonary exercise testing (CPET) and transthoracic echocardiography (TTE) 6 months after PEA, reducing the need for re-right heart catheterisation (RHC).
Article
Critical Care Medicine
Cathelijne Emma van der Bruggen, Martin Louis Handoko, Harm Jan Bogaard, Johannes Timotheus Marcus, Franciscus Petrus Theodorus Oosterveer, Lilian Jacoba Meijboom, Berend Eric Westerhof, Anton Vonk Noordegraaf, Frances S. de Man
Summary: The study compared the predictive value of noninvasive parameters with that of invasive hemodynamic measurements in patients with idiopathic PAH one year after diagnosis. Results showed that risk assessment based on CMR was at least equal to that based on RHC at 1 year of follow-up, and only changes in CMR parameters were of prognostic predictive value during the first year of follow-up, while changes in hemodynamic parameters were not predictive.
Review
Medicine, General & Internal
Tijana Tuhy, Paul M. Hassoun
Summary: Systemic sclerosis is an autoimmune disorder that affects the connective tissue and causes skin thickening and complications in the internal organs. Pulmonary involvement, including pulmonary arterial hypertension and interstitial lung disease, is the main cause of morbidity and mortality in scleroderma patients. Current treatment options are not specific to pulmonary involvement in scleroderma, and patients with pulmonary arterial hypertension in this population tend to have worse outcomes and lower response to therapy compared to other forms of Group I pulmonary hypertension.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Patricia Kaaijk, Alienke J. Wijmenga-Monsuur, Hinke I. ten Hulscher, Jeroen Kerkhof, Gaby Smits, Mioara Alina Nicolaie, Marianne A. van Houten, Rob S. van Binnendijk
Summary: This follow-up study investigated the antibody levels of mumps, measles, and rubella in young adults who received a third dose of the MMR vaccine. The results showed that the antibody levels remained elevated even 3 years after vaccination, with the strongest increase observed in individuals with low mumps antibody levels before vaccination. The study suggested that a third dose of MMR vaccine could provide additional protection during mumps outbreaks.
Article
Respiratory System
Veronica Silva Vilela, Marcio Macri Dias, Angelo Antunes Salgado, Bruno Rangel Antunes da Silva, Agnaldo Jose Lopes, Elizabeth Jauhar Cardoso Bessa, Leonardo Palermo Bruno, Claudia Henrique da Costa, Roger Abramino Levy, Rogerio Rufino
Summary: Systematic screening in a Brazilian population identified systemic sclerosis pulmonary hypertension (SSc-PH) patients with severe clinical and hemodynamic features. Mortality remains high in SSc-PH, more related to Bo-PAH and SSc-ILD-PH, while the prognosis of systemic sclerosis pulmonary arterial hypertension (SSc-PAH) was better.
BMC PULMONARY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Gustavo Lopez y Lopez, Ana Yessica Tepox Galicia, Fausto Atonal Flores, Jorge Flores Hernandez, Francisco Perez Vizcaino, Abel E. Villa Mancera, Garcia Gonzalez Miguel, Alejandro Reynoso Palomar
Summary: Clinical studies suggest that diabetes is a risk factor in the development of pulmonary arterial hypertension. Experimental diabetes-induced pulmonary arterial hypertension generated hypertrophy and systolic dysfunction of the right ventricle.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Biology
Gabriel Dias Rodrigues, Angelica Carandina, Costanza Scata, Chiara Bellocchi, Lorenzo Beretta, Pedro Paulo da Silva Soares, Eleonora Tobaldini, Nicola Montano
Summary: Systemic sclerosis (SSc) patients often experience cardiovascular autonomic dysfunction, leading to arrhythmic complications and mortality. This study aimed to evaluate the progression of cardiac autonomic impairment over time in different subsets of SSc patients. The results showed that the worsening of cardiac autonomic dysfunction was associated with the diffuse cutaneous (dcSSc) subset, which had a more extent of skin and internal organs fibrosis.
Article
Respiratory System
Paola Faverio, Fabrizio Luppi, Paola Rebora, Gabriele D'Andrea, Anna Stainer, Sara Busnelli, Martina Catalano, Giuseppe Modafferi, Giovanni Franco, Anna Monzani, Stefania Galimberti, Paolo Scarpazza, Elisa Oggionni, Monia Betti, Tiberio Oggionni, Federica De Giacomi, Francesco Bini, Bruno Dino Bodini, Mara Parati, Luca Bilucaglia, Paolo Ceruti, Denise Modina, Sergio Harari, Antonella Caminati, Marcello Intotero, Pietro Sergio, Giuseppe Monzillo, Giovanni Leati, Andrea Borghesi, Maurizio Zompatori, Rocco Corso, Maria Grazia Valsecchi, Giacomo Bellani, Giuseppe Foti, Alberto Pesci
Summary: This study investigated pulmonary sequelae in patients one year after hospitalization for SARS-CoV-2 pneumonia. The findings showed that DLCO impairment and non-fibrotic interstitial lung abnormalities were common, particularly in older patients requiring higher ventilatory support.
RESPIRATORY RESEARCH
(2022)