Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 28, Issue 1, Pages 107-118Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2016.1250344
Keywords
Glioma; Paclitaxel; drug delivery; nanoparticles; nanocomposite
Funding
- National 863 project [2014AA020509, 2015AA020303]
- National Natural Science Foundation of China [81422025, 81572990, 81301907]
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Conventional surgical methods can not completely remove the tumor cells, and an inevitable recurrence always results in death. In this study, we prepared a conformal hydrogel nanocomposite with potential to inhibit the recurrence of glioma. Based on the MRI of a patient's brain tumor cavity (BTC), we 3D-printed a mould for preparing the customized implants that could match the resection cavity. The obtained macroporous hydrogel, containing Paclitaxel (PTX) nanoparticles, could sustained release PTX. From the confocal microscopy image, we could detect that the hydrogel nanocomposite combined with nanoparticles uniformly. The nanoparticles were fabricated through a self-assembled process with PTX. Moreover, the in vitro studies showed that nanoparticles could release PTX slowly and efficiently inhibited the proliferation of tumor cells. This work prepared a conformal hydrogel nanocomposite for local delivery of paclitaxel, which could inspire the development of future protocols for precision therapy of residual glioma after surgical resection.
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