Article
Polymer Science
Pengyue Zhang, Qiong Ma, Dan He, Guohua Liu, DiWei Tang, Lu Liu, Junzi Wu
Summary: The newly synthesized glucose-and temperature-responsive random copolymer nanoparticles showed high stability and good glucose sensitivity under physiological conditions. They were non-toxic to normal cells but had a certain lethality effect on tumor cells. Animal experiments demonstrated that the nanoparticles effectively lowered blood sugar levels without causing toxic damage to tissues.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Polymer Science
Simona Morariu
Summary: Diabetes, a condition with uncontrolled blood glucose levels, has serious consequences such as blindness, heart attack, stroke, and lower limb amputation. Glucose-sensitive hydrogels that release hypoglycemic drugs in response to increased glucose levels have gained interest due to the high number of diabetes patients globally. This review focuses on recent developments in phenylboronic acid-based hydrogels that have sensitivity to glucose, making them potential candidates for insulin delivery system design. The article discusses dynamic covalent bonds, the design of glucose-responsive hydrogels, the mechanism of hypoglycemic drug release, self-healing capacity, and highlights areas for future research.
Article
Engineering, Chemical
Di Huang, Sijia Gao, Ying Luo, Xiaoman Zhou, Zhengbo Lu, Lei Zou, Keling Hu, Zhuo Zhao, Yongjun Zhang
Summary: A novel glucose-sensitive membrane with P(NIPAM-2-AAPBA) microgels as chemical valves was fabricated. Unlike other PBA-based materials, this membrane contracts in the presence of glucose instead of expanding. The blend membranes show improved water flux and antifouling properties compared to pure PVDF membrane. The glucose-sensitive permeability of the membranes is attributed to the conformational changes of P(NIPAM-2-AAPBA) microgels. The glucose sensitivity of the membranes increases with the increase of microgel content.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Yun Fu, Peng Liu, Meng Chen, Tongxia Jin, Huijing Wu, Mingyang Hei, Congrong Wang, Yufang Xu, Xuhong Qian, Weiping Zhu
Summary: Diabetes poses a significant challenge due to the need for timely insulin administration and consistent blood glucose regulation to reduce the risk of hypoglycemia. The research introduced an insulin delivery system with a glucose sensitive responsive linker for controlled insulin release under high glucose concentrations, ensuring prolonged blood glucose regulation. This system, combined with a hyaluronic-acid based microneedle patch, showed efficient in vivo glucose regulation either through subcutaneous injection or transdermal delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Qiao Huang, Haojie Yu, Li Wang, Di Shen, Xiang Chen, Nan Wang
Summary: In this study, mesoporous silica modified with phenylboronic acid was used to prepare insulin release systems by combining with polymers containing diol groups. The systems showed high loading capacity and encapsulation efficiency for insulin, as well as different glucose-responsive performance.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Siyuan Chen, Takuya Miyazaki, Michiko Itoh, Hiroko Matsumoto, Yuki Moro-Oka, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami, Akira Matsumoto
Summary: This article describes a novel polyvinyl alcohol-coated microneedle patch with an interconnected porous gel drug reservoir for enhanced skin penetration efficiency and mechanical strength. Compared to other microneedle patches, this new type of patch has stronger skin penetration ability and can achieve on-demand, long-acting transdermal insulin delivery.
Review
Biochemical Research Methods
Xiaohuan Huang, Ying Han, Junrong Li, Mingliang Tang, Guangyan Qing
Summary: Increasing evidence supports the critical role of saccharides in tumor progression, and their identification and recognition have paved the way for targeted drug preparations. Achieving fluorescence sensing of saccharides has been the focus of extensive research, leading to the design of molecular probes and nanoparticles made of different materials. This paper discusses the current status of carbohydrate sensing based on fluorescence sensing mechanisms, including phenylboronic acid-based and enzyme-based sensing platforms, and highlights efforts to improve recognition mechanisms and sensing properties.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Qiong Ma, Xi Zhao, Anhua Shi, Junzi Wu
Summary: Glucose-sensitive self-adjusting drug delivery system mimics the physiological model of insulin secretion from the human pancreas, controlling blood sugar by precisely regulating the release of hypoglycemic drugs, showing promising application prospects in diabetes treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Meng-Qi Tong, Lan-Zi Luo, Peng-Peng Xue, Yong-Hui Han, Li-Fen Wang, De-Li Zhuge, Qing Yao, Bin Chen, Ying-Zheng Zhao, He-Lin Xu
Summary: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, where the combination of insulin (Ins) and liraglutide (Lir) shows potential in preventing DN. A glucose-responsive hydrogel, KGM/PBA-PGA, was designed to enhance the synergistic effect of Ins/Lir in preventing DN progression, showing promise as a drug delivery system for treating diabetic nephropathy.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Yanming Zuo, Jingjia Ye, Wanxiong Cai, Binjie Guo, Xiangfeng Chen, Lingmin Lin, Shuang Jin, Hanyu Zheng, Ao Fang, Xingran Qian, Zeinab Abdelrahman, Zhiping Wang, Zhipeng Zhang, Zuobin Chen, Bin Yu, Xiaosong Gu, Xuhua Wang
Summary: The authors developed a microinvasive nanodrug delivery system consisting of reactive oxygen species-responsive polymers and a neurotransmitter-conjugated KCC2 agonist. The nanodrugs can cross the damaged blood-spinal cord barrier and promote recovery after spinal cord injury by scavenging reactive oxygen species and modulating inhibitory neurons. This microinvasive treatment leads to functional recovery in rats with spinal cord injury.
NATURE NANOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Yu Wang, Haojie Yu, Li Wang, Jian Hu, Jingyi Feng, Di Shen, Yichuan Hong, Jinyi Liu, Dingning Chen
Summary: Diabetes patients with impaired pancreatic function cannot effectively regulate blood glucose and currently, subcutaneous insulin injection is the only treatment option. However, this method causes intense physical pain and psychological burden. Additionally, the uncontrollable release of insulin in subcutaneous injection leads to a high risk of hypoglycemia. In this study, a glucose-sensitive microneedle patch was developed using modified chitosan particles and hydrogel, which effectively delivered insulin and achieved persistent blood glucose control. The painless and minimally invasive nature of this patch indicates its advantages as a new generation of injection therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Elsherif, Fahad Alam, Ahmed E. Salih, Bader AlQattan, Ali K. Yetisen, Haider Butt
Summary: A minimally-invasive glucose detection system based on bifocal contact lenses was developed for continuous quantitative glucose measurements. The system allows for monitoring tear glucose concentration within the physiological range of healthy individuals and diabetics. By controlling the refractive index and groove depth of the Fresnel lens, the system can detect changes in glucose concentration in tears.
Article
Biophysics
Jae Hoon Han, Cho Rim Kim, Chang Hee Min, Min Ji Kim, Se-Na Kim, Han Bi Ji, Soo Bin Yoon, Cheol Lee, Young Bin Choy
Summary: In this study, a microneedle sensor coated with a glucose-responsive composite material was proposed for measuring glucose concentrations in interstitial fluid. The composite material was prepared by blending a polymer containing glucose-responsive moieties with conductive carbon nanotubes. The sensor showed accurate measurements of glucose concentrations in animal models, comparable to a clinical glucometer.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Polymer Science
Di Shen, Haojie Yu, Li Wang, Xiang Chen, Jingyi Feng, Chengjiang Li, Wei Xiong, Qian Zhang
Summary: The phenylboronic acid-based hydrogel microneedle patch with glucose responsiveness and excellent biocompatibility demonstrates self-regulated drug releasing behaviors for improving the treatment quality of diabetics. The reversible phenylborate ester crosslinking points in the hydrogel enhance mechanical strength for skin insertion, laying the foundation for a sensitive, safe, and stable transdermal drug delivery system.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Alex C. Tseng, Toshiya Sakata
Summary: This study successfully integrated the high electrical performance of poly(3,4-ethylenedioxythiophene) complexed with poly(styrenesulfonate) and the structural and electrochemical functions of a poly(acrylamide) second network incorporating phenylboronicacid in composite hydrogels. The free-standing hydrogels showed excellent performance in terms of hydration and conductivity, and could be used as channels for organic electrochemical transistors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)