Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 27, Issue 9, Pages 793-804Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2016.1143320
Keywords
Magnetic nanocomposite; polyhydroxybuthyrate (PHB); gamma-Fe2O3 nanoparticles; physical and mechanical analyses; cell separation
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Magnetic separation has numerous advantages in isolating cancerous and normal cells used in the diagnosis and treatment sectors. Here, we produced magnetic nanocomposite films made of polyhydroxybutyrate (PHB)/magnetite nanoparticles (gamma-Fe2O3), and the properties of the films by SEM, TEM, FTIR, DMTA, contact angle, and cellular analyses were investigated. The microscopic images showed uniform distribution of gamma-Fe2O3 magnetic nanoparticles in polymeric matrix. The chemical bounds between magnetic nanoparticles and polymeric matrix demonstrated using the FTIR spectrophotometer. The DMTA and contact angle results indicated an increase in the glass transition temperature and hydrophilic properties of nanocomposites is achieved by increasing the magnetic nanoparticles amount in polymer matrix. The cellular results were showed that adhesion of cancer cells compared to normal cells was significantly enhanced by the induction of a magnetic field. These nanocomposite films can be used as a substrate for cellular adhesion and separation processes.
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