Article
Materials Science, Multidisciplinary
Fengyuan Gao, Tingting Han, Muhammad Rafiq, Luping Chen, Song Wang, Jian Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: In this study, gelatin microspheres (GMs) were prepared as an embolization material that combines silver sulfide quantum dots (Ag2S QDs) and barium sulfate (BaSO4), providing good near-infrared second region (NIR-II) and X-ray imaging effects. The microspheres also demonstrated sustained drug release and rapid embolization properties, making them suitable for tumor therapy. Furthermore, the combination of NIR-II and X-ray multimodal imaging technology in this work shows great potential for clinical embolization applications in biomedical imaging.
ACS MATERIALS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Qing-Feng Li, Hongjun Xia, Erqing Li, Jin-Tao Wang, Zhenling Wang
Summary: This study successfully synthesized a hybrid material that can control luminescence through light stimuli, achieving the switching of luminescence of Eu3+ ions between ON and OFF states through repeated cycles of UV and visible light irradiation. This opens the possibility of developing lanthanide-based photoswitches for optical anti-counterfeiting and data storage.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Emel Kirbas Cilingir, Meghana Sankaran, Jordan M. Garber, Frederic Anthony Vallejo, Mattia Bartoli, Alberto Tagliaferro, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: Carbon dots (CDs) have gained attention for their biocompatibility and tunable photoluminescence, but further analysis is needed before their use in clinical trials. A new type of carbon nitride dot (CND) has been found to selectively uptake cancer cells due to structural similarities with glutamine. The study investigates the effects of surface structural differences on the cellular uptake of CNDs and finds that the uptake mechanism is linked with ASCT2 and LAT1 transporters. CNDs show promise for selective cancer cell targeting by utilizing highly expressed transporters on cancer cells.
Article
Chemistry, Multidisciplinary
Cheng Lv, Jian Ao, Ji Wang, Man Tang, An-An Liu, Dai-Wen Pang
Summary: A host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers with maintained biofunctions, which can be further multi-functionalized for tumor real-time imaging and therapy. This cell-based strategy facilitates the development and widespread application of bio-nanocarriers in targeted cancer therapy and promotes interdisciplinary studies of nanotechnology, chemistry, and virology.
Review
Oncology
Duoli Xie, Zhuqian Wang, Jie Li, De-an Guo, Aiping Lu, Chao Liang
Summary: Osteosarcoma is an aggressive bone cancer with unknown molecular pathways, making it difficult to improve patient survival. Conventional therapies have severe side effects due to the lack of selectivity for malignant tissue. Researchers are exploring targeted treatment methods by combining specific ligands and chemotherapeutic agents to treat tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Polymer Science
Jose Varghese Rajendran, Sundararajan Parani, Vasudevan Pillay R. Remya, Thabang C. C. Lebepe, Rodney Maluleke, Olanrewaju A. A. Aladesuyi, Sabu Thomas, Oluwatobi Samuel Oluwafemi
Summary: Researchers developed a novel system composed of gelatin stabilized, mesoporous silica SBA15 encapsulated CuInS2/ZnS quantum dots (QDs) conjugated with beta-cyclodextrin (beta-CDs) for efficient release of the anticancer drug camptothecin (CPT). The system demonstrated excellent fluorescence properties, high photostability, and a drug release profile following the triphasic model. The beta-CD conjugated Gel-SBA15-CIS/ZnS QD nanocomposite holds great promise for both imaging and therapeutic applications.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuyao Liu, Zhuoling Zhong, Chuanwei Zhang, Yanqu Zhou, Chunmei Fu, Xiaoping Xu
Summary: Iron-doped orange emissive carbon dots (ICDs) were synthesized using the hydrothermal method and coupled with Trf and glucose oxidase (GOD) to achieve multifunctional enzymolysis of glucose, decomposition of H2O2, and release of ROS in gliomas for efficient targeted killing effect.
NANOSCALE ADVANCES
(2022)
Article
Engineering, Environmental
Danmin Lin, Mingchao Li, Yifei Gao, Liang Yin, Yanqing Guan
Summary: The newly developed brain-targeted ZnO quantum dots nanoplatform can deliver gene for interfering with the expression of α-synuclein in Parkinson's disease, providing a potential therapeutic strategy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Lai-Di Xu, Jin Zhu, Shou-Nian Ding
Summary: Direct synthesis of carbon dots on uniform mesoporous nanospheres is an ideal way to incorporate fluorescence properties while maintaining uniformity. Carbon dot-based nanospheres with high quantum yield have excellent chemical properties, enabling sensitive, specific, rapid, and cost-effective detection of anthrax protective antigen.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Inorganic & Nuclear
Dangge Gao, Ying Zhang, Bin Lyu, Xu Guo, Yelin Hou, Jianzhong Ma, Bingzhe Yu, Shaowei Chen
Summary: Extraordinarily stable CsSnCl3 nanocrystals were prepared by exploiting bone gelatin as capping agents, leading to an improved photoluminescence quantum yield. These nanocrystals can be used for detecting metal ions, indicating their potential application in fluorescence sensors and detectors.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tongtong Che, Yukun Song, Wentao Su, Shanghua Xing, Haitao Wang, Mingqian Tan
Summary: In this study, hepatic parenchymal cell and mitochondrial-targeted nanocarriers were developed to deliver AST to liver tissue for improved intervention in NAFLD. The AST@TPP-WPI-Gal nanocarriers exhibited dual targeting capability and effectively targeted mitochondria in steatotic cells, leading to enhanced anti-oxidative and anti-adipogenesis effects. In an NAFLD mice model, the AST@TPP-WPI-Gal nanocarriers showed the ability to regulate blood lipid disorders, protect liver function, and significantly reduce liver lipid accumulation compared to free AST.
Article
Chemistry, Multidisciplinary
Yanjie Huang, Dong Liu, Ruirui Guo, Bin Wang, Zhengzuo Liu, Yijia Guo, Jian Dong, Yuan Lu
Summary: This study developed a multifunctional magnetic nanozyme antibacterial strategy, utilizing magnetic control technology and highly toxic radicals to disrupt bacterial biofilms, with potential for combating drug-resistant bacterial infections.
Article
Chemistry, Analytical
Yizhong Shen, Tingting Wu, Yuqi Wang, Shao-Lin Zhang, Xueli Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: A novel ratiometric fluorescent method was developed to sensitively and specifically report Cathepsin B (CTSB) activity by integrating cancer-targeting recognition moiety and a large emission wavelength shift into a single matrix.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sangram Keshari Samal, Stefaan Soenen, Dario Puppi, Karolien De Wael, Sanghamitra Pati, Stefaan De Smedt, Kevin Braeckmans, Peter Dubruel
Summary: In this study, a bio-nanohybrid gelatin protein/cadmium sulfide quantum dot system was developed via a one-pot strategy. The system showed potential applications in cellular imaging and electrochemical sensing, with the advantage of easy and convenient operation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ojodomo J. Achadu, Njemuwa Nwaji, Dongkyu Lee, Jaebeom Lee, Eser M. Akinoglu, Michael Giersig, Enoch Y. Park
Summary: The novel hierarchically porous 3D magnetic molybdenum trioxide-polydopamine-gold functionalized nanosphere (3D mag-MoO3-PDA@Au NS) shows great potential for pathogen detection, overcoming challenges in Raman signal stability and reproducibility, and achieving ultrasensitive detection of SARS-CoV-2 spike protein.
NANOSCALE ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
Xueqin Zhao, Chao Lu, Songlin Yang, Jin Zhang
Review
Biochemistry & Molecular Biology
Jisu Song, Chao Lu, Jerzy Leszek, Jin Zhang
Summary: This paper examines the challenges of treating CNS diseases due to the blood-brain barrier (BBB), focusing on the importance of understanding BBB transport mechanisms for developing novel drug carriers. Strategies for crossing the BBB using nanomaterial-based drug carriers and the potential use of neurotropic viruses as an alternative solution are discussed. Additionally, recent studies on virus-mimicking nanocarriers for drug delivery and routes of administration to the CNS are reviewed to advance the diagnosis and treatment of CNS diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Yingqi Zhang, Chao Lu, Jin Zhang
Summary: Lactoferrin, a major functional protein in human health maintenance, has potential as a biomarker for diseases such as inflammatory bowel disease and Alzheimer's disease. Various methods have been developed for detecting lactoferrin levels. These studies aim to inspire the development of new sensing systems for lactoferrin detection.
Review
Chemistry, Analytical
Songlin Yang, Jin Zhang
Summary: Magnetoresistance (MR) is the change in resistivity of a material when exposed to an external magnetic field. Its most common application is in the reading heads of hard disk drives (HDDs). Since the discovery of giant magnetoresistance (GMR) in the 1980s, MR sensors have significantly contributed to the rapid development of HDD storage capacity and are now widely used in magnetic storage, position sensing, current sensing, and biomedical applications.
Article
Materials Science, Multidisciplinary
Songlin Yang, Jin Zhang
Summary: The challenges in commercializing spintronic devices are addressed by developing hybrid graphene nanosheets using the MAPLE technique, which exhibit magnetoresistance (MR) phenomenon at low magnetic fields and room temperature. These findings suggest that graphene-based materials have potential for spintronic device applications.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Surgery
Richard Wagner, Paula Lieckfeldt, Hadeesha Piyadasa, Moritz Markel, Jan Riedel, Camelia Stefanovici, Nicole Peukert, Daywin Patel, Gabrielle Derraugh, Suyin A. Lum Min, Jan-Hendrik Gosemann, Jan Deprest, Christopher D. Pascoe, Wai Hei Tse, Martin Lacher, Neeloffer Mookherjee, Richard Keijzer
Summary: The pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains unclear. Proteomic analysis revealed significant differences in inflammatory response proteins between CDH lungs and non-CDH control lungs. Tenascin C was decreased while STAT3 was significantly increased in CDH lungs. Inhibition of STAT3 partially rescued the hypoplastic lung phenotype in CDH. These findings indicate the involvement of downstream inflammatory processes in the abnormal lung development of CDH.
Review
Biochemistry & Molecular Biology
Chao Lu, Etienne Joulin, Howyn Tang, Hossein Pouri, Jin Zhang
Summary: This review investigates the applications of upconversion (UC) nanostructures in therapeutic systems. Lanthanide (Ln)-doped UC nanostructures can be used for therapeutic systems and organic molecular-based UC nanostructures have high UC quantum yields and do not require high excitation power due to the triplet-triplet annihilation (TTA) UC mechanism. The review also summarizes the current progress in the diagnosis and therapy using UC nanostructures and provides insight into future developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yingqi Zhang, Howyn Tang, Wei Chen, Jin Zhang
Summary: Fluorescence polarization (FP) has been widely used in detecting chemicals and biomolecules. Nanomaterials play a crucial role in FP-based biosensors, enhancing fluorescence stability and serving as signal amplifiers. FP-based biosensing systems have advantages in terms of sensitivity and cost-effectiveness compared to other fluorescence techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Xuanjun Hu, Chao Lu, Howyn Tang, Hossein Pouri, Etienne Joulin, Jin Zhang
Summary: Food packaging plays a crucial role in protecting and preserving food. Conventional packaging made of non-biodegradable plastics derived from fossil fuels has a negative impact on the environment. Natural biopolymers offer a sustainable alternative due to their abundance and eco-friendly properties. This review discusses the use of natural biopolymers as matrices for food packaging, highlighting their antioxidant, water barrier, and oxygen barrier properties. Additionally, the integration of antimicrobial agents in biopolymer-based composites is explored, with a focus on inhibiting microbial growth and maintaining food quality.
Article
Materials Science, Multidisciplinary
W. H. Tse, S. Yang, J. Zhang
Summary: Biocompatible nanostructures provide new pathways for overcoming obstacles in conventional anti-angiogenic therapy. However, current technology is limited by therapeutics' bioavailability and imaging obstruction. In this paper, a theranostic system based on cubic lanthanide-based upconversion nanoparticles (UCNPs) has been developed. The UCNPs exhibit strong anti-angiogenic effects and cell imaging capabilities.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Applied
Xueqin Zhao, Chao Lu, Songlin Yang, Rui Ni, Tianqing Peng, Jin Zhang
Summary: In this study, TMC-based nanospheres were successfully developed as an effective carrier for curcumin. These nanospheres exhibited delayed and first-order release kinetics. The cytotoxicity study showed that synthetic TMC had no toxic effects on cells, and the use of TMC nanospheres loaded with curcumin increased the relative cell viability.
FOOD HYDROCOLLOIDS FOR HEALTH
(2022)
Article
Nanoscience & Nanotechnology
Yingqi Zhang, Jisu Song, Songlin Yang, Jianying Ouyang, Jin Zhang
Summary: The early diagnosis of breast cancer can be achieved through the detection of mutant DNA at low concentrations using a carbon nanostructure-based DNA sensing system. The system combines carbon quantum dots and graphene oxide nanosheets for quick detection of breast cancer-associated single-strand DNA. The fluorescence of the carbon quantum dots is quenched when they interact with graphene oxide, but is restored in the presence of the target single-strand DNA. The system has a linear relationship between the restored fluorescence intensity and the concentration of the target DNA, with a low detection limit.
NANOSCALE RESEARCH LETTERS
(2022)
Article
Materials Science, Biomaterials
Wai Hei Tse, Sean Higgins, Daywin Patel, Malcolm Xing, Adrian R. West, Hagar I. Labouta, Richard Keijzer
Summary: Research has shown that maternal-fetal transfer of passive immunity can facilitate the transplacental transfer of IgG-modified nanoparticles, increasing their transport efficiency. Confocal microscopy revealed colocalization of FcRn and IgG-modified nanoparticles. Barrier function remained intact before and after nanoparticle administration.
BIOMATERIALS SCIENCE
(2022)
Article
Pediatrics
Moritz Markel, Wai Hei Tse, Nolan DeLeon, Daywin Patel, Shana Kahnamouizadeh, Martin Lacher, Richard Wagner, Richard Keijzer
Summary: The absence of miR-200b results in abnormal lung development, with dysregulation of Tenascin C potentially contributing to lung hypoplasia in miR-200b(-/-) mice.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
