Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations

Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104

(2016) Elizabeth A. Sweeny et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection

(2014) Virginia Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amplification of Tau Fibrils from Minute Quantities of Seeds

(2014) Virginia Meyer et al.   BIOCHEMISTRY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

(2014) Simon Dujardin et al.   Acta Neuropathologica Communications

Long-Range Distances in Amyloid Fibrils of α-Synuclein from PELDOR Spectroscopy

(2013) S. Pornsuwan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

The Evolution of Transmissible Prions: The Role of Deformed Templating

(2013) Natallia Makarava et al.   PLoS Pathogens

Cross-seeding and Conformational Selection between Three- and Four-repeat Human Tau Proteins

(2012) Xiang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau

(2012) Ayisha Siddiqua et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

A new perspective on Hsp104-mediated propagation and curing of the yeast prion [PSI+]

(2012) Christopher W. Helsen et al.   Prion

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Variations in Filament Conformation Dictate Seeding Barrier between Three- and Four-Repeat Tau

(2011) Paul D. Dinkel et al.   BIOCHEMISTRY

Electron Paramagnetic Resonance Spectroscopy Measures the Distance between the External β-Strands of Folded α-Synuclein in Amyloid Fibrils

(2011) Irina Karyagina et al.   BIOPHYSICAL JOURNAL

Prions on the move

(2011) Charles Weissmann et al.   EMBO REPORTS

Fibril Structure of Human Islet Amyloid Polypeptide

(2011) Sahar Bedrood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Three- and Four-repeat Tau Coassemble into Heterogeneous Filaments

(2010) Ayisha Siddiqua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transfer of a prion strain to different hosts leads to emergence of strain variants

(2010) S. P. Mahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

(2010) R. C. Angers et al.   SCIENCE

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

(2009) David R Williams et al.   LANCET NEUROLOGY

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

(2008) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY