Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy

GSH and H 2 O 2 Co‐Activatable Mitochondria‐Targeted Photodynamic Therapy under Normoxia and Hypoxia

(2020) Jian Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

(2020) Yangxin Li et al.   Frontiers in Pharmacology

Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications

(2020) Hai-xia Xu et al.   ACTA PHARMACOLOGICA SINICA

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

(2020) Yu-Bin Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

(2020) Ziliang Dong et al.   Chem

Intracellular Ca2+ Cascade Guided by NIR-II Photothermal Switch for Specific Tumor Therapy

(2020) Zhaoyu Ma et al.   iScience

Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies

(2020) Sainan Liu et al.   ACS Applied Materials & Interfaces

Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu 2 O@CaCO 3 Nanocomposites for Synergistic Oncotherapy

(2020) Mengyu Chang et al.   ADVANCED MATERIALS

Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

(2020) Yongxin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

(2020) Ziling Zeng et al.   ADVANCED MATERIALS

Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles

(2019) Jian Qing Peng et al.   JOURNAL OF CONTROLLED RELEASE

Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors

(2019) Shengcai Yang et al.   ADVANCED MATERIALS

One‐Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy

(2019) Sainan Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy

(2019) Xuechao Cai et al.   Advanced Science

Monodispersed CuSe Sensitized Covalent Organic Framework Photosensitizer with an Enhanced Photodynamic and Photothermal Effect for Cancer Therapy

(2019) Chunling Hu et al.   ACS Applied Materials & Interfaces

Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition

(2019) Wencheng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

(2019) Yu-Bin Dong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Precisely Striking Tumors without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation

(2018) Zhaoyu Ma et al.   ACS Nano

Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity

(2018) Ziliang Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine

(2018) Shuang Wang et al.   Small

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

(2018) Zhenzhen Wang et al.   Nature Communications

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Targeting calcium signaling in cancer therapy

(2017) Chaochu Cui et al.   Acta Pharmaceutica Sinica B

CaCO3 nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy

(2016) Ziliang Dong et al.   BIOMATERIALS

Nanoscale covalent organic frameworks as smart carriers for drug delivery

(2016) Linyi Bai et al.   CHEMICAL COMMUNICATIONS

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems

(2016) Ying Jiang et al.   Expert Opinion on Drug Delivery

Mitochondrial Ca2+ and regulation of the permeability transition pore

(2016) Stephen Hurst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons

(2016) Yan Lyu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

(2016) Xuejiao Song et al.   NANO LETTERS

CypD: The Key to the Death Door

(2015) Shaik Fayaz et al.   CNS & Neurological Disorders-Drug Targets

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

(2015) Santhanam Shanmughapriya et al.   MOLECULAR CELL

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

A Preloaded Amorphous Calcium Carbonate/Doxorubicin@Silica Nanoreactor for pH-Responsive Delivery of an Anticancer Drug

(2014) Yang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prostate Cancer Cells Alter the Nature of Their Calcium Influx to Promote Growth and Acquire Apoptotic Resistance

(2014) Gregory R. Monteith   CANCER CELL

Nanotechnology Applications in Surgical Oncology

(2010) Sunil Singhal et al.   Annual Review of Medicine

Calcium wave signaling in cancer cells

(2010) Jai Parkash et al.   LIFE SCIENCES

Mitochondria as targets for chemotherapy

(2009) Vladimir Gogvadze et al.   APOPTOSIS