Article
Nutrition & Dietetics
Silvia Espina, Alejandro Sanz-Paris, Yolanda Gonzalez-Irazabal, Patricia Perez-Matute, Fernando Andrade, Beatriz Garcia-Rodriguez, Christian Carpene, Alexia Zakaroff, Vanesa Bernal-Monterde, Javier Fuentes-Olmo, Jose M. Arbones-Mainar
Summary: Oral HMB supplementation improves liver function and increases fat mass index, but has no effect on fat-free mass. In patients with cirrhosis and malnutrition, the HMB group showed an upward trend in handgrip strength and a downward trend in minimal hepatic encephalopathy.
Review
Medicine, General & Internal
Silvia Espina, Alejandro Sanz-Paris, Vanesa Bernal-Monterde, Diego Casas-Deza, Jose Miguel Arbones-Mainar
Summary: BCAA supplementation can slightly increase muscle mass and body mass index, improve symptoms of hepatic encephalopathy, and is indicated as second-line therapy in liver cirrhosis. The effect of HMB supplementation on muscle mass in liver cirrhosis studies has not been clearly demonstrated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Begona Molina-Baena, Jose Antonio Carnicero, Suzette L. Pereira, Francisco Jose Garcia-Garcia, Angela Santos-Fandila, Ricardo Rueda Cabrera, Leocadio Rodriguez-Manas
Summary: The study aimed to assess the association between endogenous plasma HMB levels and frailty status. The findings showed an inverse association between HMB levels and frailty, suggesting the potential benefits of HMB supplementation for older frail individuals.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Nutrition & Dietetics
Ziru Lin, Anqi Zhao, Jiguo He
Summary: This meta-analysis demonstrates that supplementation of HMB and preparations containing HMB ingredients can increase muscle strength in elderly individuals, which is crucial for their overall health.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Kym Wittholz, Kate Fetterplace, Amalia Karahalios, Yasmine Ali Abdelhamid, Lisa Beach, David Read, Rene Koopman, Jeffrey J. Presneill, Adam M. Deane
Summary: This study aimed to determine the feasibility of administering a blinded nutrition supplement in the ICU and continuing it after ICU discharge. The results showed that daily enteral supplementation of 3g HMB for up to 28 days is feasible, but the effect of HMB on attenuating muscle wasting after traumatic injury remains uncertain.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Yosuke Tsuchiya, Hisashi Ueda, Naoki Sugita, Eisuke Ochi
Summary: The study found that low-dose HMB supplementation significantly improved maximal voluntary contraction torque and range of motion in muscles, and helped reduce muscle damage. The results of this study provide new insights into the application of HMB in reducing muscle damage.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Mara Nichetti, Gabriella Peroni, Maurizio Naso, Milena Anna Faliva, Giancarlo Iannello, Enrica Di Paolo, Simone Perna
Summary: This study demonstrated that a 4-week intake of arginine, glutamine, and HMB significantly reduces visceral adipose tissue (VAT) and improves skin condition while maintaining fat free mass (FFM), achieving high-quality weight loss.
Review
Biochemistry & Molecular Biology
Abdolvahab Ebrahimpour Gorji, Piotr Ostaszewski, Kaja Urbanska, Tomasz Sadkowski
Summary: Skeletal muscle serves as a protein reservoir and plays a crucial role in regulating glucose and lipid homeostasis. Mutations in the dystrophin gene cause muscular dystrophy, a neuromuscular condition characterized by progressive muscle weakness and shortened lifespan. The use of HMB, a dietary supplement, has shown promising effects in preventing muscle loss and improving overall health in pathological conditions. This study aims to identify common genes, metabolic pathways, and biological processes between DMD and HMB, and discuss their interaction and consequences.
Article
Rehabilitation
Rafael Fortuna, Andrew Sawatsky, John C. Fuller, Walter Herzog
Summary: The study found that while HMB did not completely prevent muscle mass and strength loss induced by BoNT-A injection, it did reduce the loss of contractile material in the injected muscles and prevented strength loss in the contralateral non-injected muscles.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Nutrition & Dietetics
Piotr Kaczka, Katarzyna Kubicka, Amit Batra, Marcin Maciejczyk, Edyta Kopera, Justyna Bira, Tomasz Zajac
Summary: This study aimed to investigate the effect of simultaneous supplementation of beta-hydroxy-beta-methylbutyrate and L-Arginine alpha-ketoglutarate on lower limb power and muscle damage in medium distance runners aged 15.3 years old. The results suggested that the supplement combination may help prevent a reduction in jump performance during training, but showed no influence on markers of muscle damage or mood.
Article
Nutrition & Dietetics
Isabel Cornejo-Pareja, Maria Ramirez, Maria Camprubi-Robles, Ricardo Rueda, Isabel Maria Vegas-Aguilar, Jose Manuel Garcia-Almeida
Summary: The study demonstrates the positive impact of a high-calorie, high-protein oral nutritional supplement with HMB on improving nutritional status, increasing body weight, and muscle-related parameters, especially in enhancing muscle health.
Article
Nutrition & Dietetics
Alejandro Barranco, Llenalia Garcia, Agnes Gruart, Jose Maria Delgado-Garcia, Ricardo Rueda, Maria Ramirez
Summary: HMB, a metabolite of leucine, has been shown to preserve muscle mass and strength during aging. This study evaluated the effects of different doses of HMB on synaptic potentiation in the hippocampus and working memory in animals. The results suggest that medium or high doses of HMB can enhance neuronal plasticity and improve cognitive performance.
Article
Nutrition & Dietetics
Hidehiko Nakano, Hideki Hashimoto, Masaki Mochizuki, Hiromu Naraba, Yuji Takahashi, Tomohiro Sonoo, Yujiro Matsuishi, Yasuhiro Ogawa, Nobutake Shimojo, Yoshiaki Inoue, Kensuke Nakamura
Summary: The administration of HMB complex in elderly minor trauma patients did not improve muscle injury, however titin values may be associated with subsequent physical function.
Article
Nutrition & Dietetics
Samanta Catherine Ferreira, Nathalia Pereira de Souza, Leandro Ricardo de Navarro Amado, Julio Onesio Ferreira Melo, Ilka Afonso Reis B. Stat, Lucilene Rezende Anastacio
Summary: This study aimed to evaluate the effects of P-hydroxy P-methylbutyrate (HMB) supplementation on muscle mass, strength, functionality, and quality of life in patients on the liver transplantation (LTx) waiting list. A total of 47 patients were enrolled in a double-blind, randomized study, and the results showed that HMB supplementation significantly improved muscle mass, strength, and functionality compared to the control group. These findings suggest that nutritional counseling with HMB supplementation may have potential benefits for patients on the LTx waiting list.
Review
Endocrinology & Metabolism
Nicolas de Angelus Costa Riela, Maiara Moeme Alvim Guimaraes, Daniela Oliveira de Almeida, Edilene Maria Queiroz Araujo
Summary: The aging process affects body composition by increasing abdominal adipose tissue and decreasing lean body mass. Beta-hydroxy-beta-methylbutyrate (HMB) has been shown to have positive effects on body composition and strength in elderly individuals, especially when they are bedridden or sedentary. Supplementation of 3 g of HMB has shown to be most beneficial in improving strength and body composition in people over 65 years.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Orthopedics
Fatemeh Baghbani-Naghadehi, Susan Armijo-Olivo, Carla M. Prado, Linda J. Woodhouse
Summary: This study investigated the association between obesity, comorbidities, and peri/postoperative complications in patients who underwent TKA surgery. The findings showed that patients with higher BMI or comorbidities were more likely to experience complications, particularly diabetes, pulmonary embolism, and wound infection.
JOURNAL OF KNEE SURGERY
(2023)
Article
Nutrition & Dietetics
Fabiana Lascala, Bruna Karoline da Silva Moraes, Maria Carolina Santos Mendes, Mariluce Barbosa de Carvalho, Sandra Regina Branbilla, Ademar Dantas da Cunha Junior, Luiz Roberto Lopes, Nelson Adami Andreollo, Ligia Traldi Macedo, Carla M. Prado, Jose Barreto Campello Carvalheira
Summary: This study aimed to investigate the association between systemic inflammation and myosteatosis upon diagnosis of gastric cancer (GC) and their predictive role in survival outcomes. The study found that patients with low skeletal muscle radiodensity were more likely to be older, have a higher body mass index, and have diabetes. High skeletal muscle radiodensity was associated with better disease-free survival and overall survival. Patients with a neutrophil-to-lymphocyte ratio (NLR) > 2.3 and myosteatosis had the worst survival outcomes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Katherine L. Ford, Claire F. Trottier, Wendy V. Wismer, Michael B. Sawyer, Mario Siervo, Nicolaas E. P. Deutz, Carla M. Prado, Helen Vallianatos
Summary: This qualitative study explored the dietary decisions made by patients with colorectal cancer (CRC) starting chemotherapy. The results showed that patients' dietary choices were influenced by medical factors, health beliefs, fixed diets, and external influences. Understanding these factors can guide healthcare providers in providing tailored dietary support for CRC patients.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Nutrition & Dietetics
Chet Morrison, Carla M. Prado, Paul Wischmeyer, Robert G. Martindale, Jose Pimiento, Jennifer Katz, Jeffrey Mechanick, Jayshil J. Patel
Summary: Patients requiring complex or extensive surgery often face perioperative and postoperative nutrition risk. Providing adequate nutrition to these patients remains a clinical challenge. The American Society for Parenteral and Enteral Nutrition 2022 Preconference discussed novel strategies for assessing nutrition risk, enhancing recovery after surgery, and managing nutrition before and after surgery in complex surgical patients.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Amy A. Kirkham, Katherine L. Ford, Bruna Ramos Da Silva, Jordan Topolnyski, Carla M. Prado, Anil A. Joy, D. Ian Paterson, Normand Boule, Edith Pituskin, Mark J. Haykowsky, Richard B. Thompson
Summary: This study evaluated the feasibility and preliminary efficacy of telephone-based delivery of weekday-only time-restricted eating. The results showed that telephone-delivered weekday TRE was a feasible, acceptable, low-symptom, and low-cost intervention. However, despite clinically relevant changes occurring within individual participants, there were no significant changes in overall metabolic syndrome, lipid profile, or hemoglobin A(1c) and no changes in hepatic steatosis and thigh myosteatosis. Dietary intake changes included reduced energy and protein, while physical activity and sleep did not change.
Article
Endocrinology & Metabolism
Bruna Ramos da Silva, Camila E. Orsso, Maria Cristina Gonzalez, Juliana Maria Faccioli Sicchieri, Mirele Savegnago Mialich, Alceu A. Jordao, Carla M. Prado
Summary: Phase angle, a composite measure of bioelectrical impedance analysis, has been explored as an indicator of cellular health, inflammation, and oxidative stress. It has been shown to be associated with markers of inflammation and oxidative stress, suggesting its potential utility in early detection and monitoring of these conditions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
Maurizio Muscaritoli, Gil Bar-Sela, Nicolo Matteo Luca Battisti, Borislav Belev, Jorge Contreras-Martinez, Enrico Cortesi, Ione de Brito-Ashurst, Carla M. Prado, Paula Ravasco, Suayib Yalcin
Summary: Early identification of malnourished or at-risk patients is essential for optimizing treatment success in oncology. The PRONTO protocol provides guidance for oncologists to identify and evaluate patients with malnutrition or muscle depletion and offers support options. Its adaptability makes it feasible for implementation in different settings and countries, particularly where specialized nutrition care is not available.
Review
Nutrition & Dietetics
Alcides C. de Morais Junior, Raquel M. Schincaglia, Ricardo B. Viana, Anissa M. Armet, Carla M. Prado, Jens Walter, Joao F. Mota
Summary: This study assessed the impact of oats or fi-glucan supplements on lipid profiles through a systematic review and meta-analysis. The results showed that both oats and fi-glucan improved lipid profiles, indicating their potential role in preventing cardiovascular diseases.
CLINICAL NUTRITION ESPEN
(2023)
Review
Nutrition & Dietetics
Montserrat Montes-Ibarra, Camila E. Orsso, Ana Teresa Limon-Miro, Maria Cristina Gonzalez, Emanuele Marzetti, Francesco Landi, Steven B. Heyms, Rocco Barazzoni, Carla M. Prado
Summary: This study summarized the evidence on body composition abnormalities and their relationship with adverse clinical outcomes in patients with COVID-19. The findings showed that body composition abnormalities were prevalent among patients, with lower muscle density and decreased phase angle being associated with higher mortality risk, while increased visceral adipose tissue was associated with higher risk of ICU admission.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Katherine L. Ford, Claude Pichard, Michael B. Sawyer, Claire F. Trottier, Ilana Roitman Disi, Sarah A. Purcell, Sunita Ghosh, Mario Siervo, Nicolaas E. P. Deutz, Carla M. Prado
Summary: This study aimed to assess TEE in cancer patients, identify its predictors, and compare it with cancer-specific predicted energy requirements. The results showed that absolute TEE was higher in males, patients with colon cancer, and patients with obesity. TEE was lower than predicted requirements, indicating the need for improved assessment of energy requirements in cancer patients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Orthopedics
Kristine Godziuk, Carla M. M. Prado, Maira Quintanilha, Mary Forhan
Summary: This study evaluated the acceptability and preliminary effectiveness of a multimodal digital nutrition, exercise, and mindfulness intervention in adults with knee osteoarthritis. The results showed that the intervention was acceptable to the patients and had preliminary effectiveness in improving self-efficacy and quality of life.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Geriatrics & Gerontology
Nicole Kiss, Carla M. Prado, Robin M. Daly, Linda Denehy, Lara Edbrooke, Brenton J. Baguley, Steve F. Fraser, Abbas Khosravi, Gavin Abbott
Summary: This study compared the prevalence of low muscle mass, malnutrition, and sarcopenia in cancer patients from the UK Biobank, and explored the influence of different methods of adjusting muscle mass estimates. The study found that all conditions were associated with increased mortality risk. Adjusting muscle mass for body mass index identified more cases in obese participants.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Nutrition & Dietetics
Bruna Ramos Da Silva, Amy A. Kirkham, Katherine L. Ford, Mark J. Haykowsky, D. Ian Paterson, Anil A. Joy, Edith Pituskin, Richard Thompson, Carla M. Prado
Summary: The aim of this study was to evaluate the association between phase angle (PhA) obtained from bioelectrical impedance analysis (BIA) and health-related physical fitness (including cardiorespiratory fitness, skeletal muscle volume, and myosteatosis) among older breast cancer survivors. The results showed that higher values of PhA were associated with better health-related physical fitness among this population.
CLINICAL NUTRITION ESPEN
(2023)
Article
Health Care Sciences & Services
Joao F. Mota, Lorena C. C. Lopes, Claire F. Trottier, Steve T. Johnson, Jessica Lieffers, Carla M. Prado
Summary: This study evaluated the effects of a web-based program, My Viva Plan, on stress indicators and diet quality among first-year university students. The results showed that the intervention was not associated with improvements in stress indicators, diet quality, and body composition, possibly due to the characteristics of the healthy young individuals in the study cohort. Future studies should focus on enhancing motivational approaches to explore the potential of e-health interventions that improve health behavior.
TELEMEDICINE REPORTS
(2023)
Review
Critical Care Medicine
Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. Mcclave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe, Arthur R. H. van Zanten
Summary: Personalization of ICU nutrition is important for the future of critical care. Guidelines recommend low-dose enteral or parenteral nutrition within 48 hours of admission, with consideration for alternative routes when necessary. Indirect calorimetry should be used to measure energy expenditure, and protein delivery should be adjusted based on patient stability. Micronutrient evaluation and muscle monitoring are also important considerations in post-ICU nutrition. Further research is needed on specialized anabolic nutrients and rehabilitation interventions for post-ICU recovery.