Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury

Nuclear Magnetic Resonance Insight into the Multiple Glycosaminoglycan Binding Modes of the Link Module from Human TSG-6

(2016) Younghee Park et al.   BIOCHEMISTRY

The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations

(2016) Carsten Scavenius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions

(2016) Douglas P. Dyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

(2016) Vivien J. Coulson-Thomas et al.   Ocular Surface

Anti-inflammatory cytokine TSG-6 inhibits hypertrophic scar formation in a rabbit ear model

(2015) Hui Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system

(2015) Patrice D. Smith et al.   EXPERIMENTAL NEUROLOGY

Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix

(2015) David C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

(2015) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

(2015) Nadine Nagy et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Protein Tumor Necrosis Factor-α–Stimulated Protein 6 (TSG-6) Promotes Early Gingival Wound Healing: An In Vivo Study

(2015) Stacy R. Beltran et al.   JOURNAL OF PERIODONTOLOGY

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

(2014) M. Bogdani et al.   DIABETES

Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues

(2014) Mariya S Spasova et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Irreversible Heavy Chain Transfer to Chondroitin

(2014) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Umbilical Cord Mesenchymal Stem Cells Suppress Host Rejection

(2014) Vivien Jane Coulson-Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

(2014) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan

(2014) Victoria A. Higman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modification of Hyaluronan by Heavy Chains of Inter-α-Inhibitor in Idiopathic Pulmonary Arterial Hypertension

(2014) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TSG-6 Inhibits Neutrophil Migration via Direct Interaction with the Chemokine CXCL8

(2014) D. P. Dyer et al.   JOURNAL OF IMMUNOLOGY

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity

(2013) D. J. Kota et al.   DIABETES

Inter-α-inhibitor Impairs TSG-6-induced Hyaluronan Cross-linking

(2013) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury

(2013) Beatriz Rodriguez-Grande et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Administration of TSG-6 improves memory after traumatic brain injury in mice

(2013) Jun Watanabe et al.   NEUROBIOLOGY OF DISEASE

Dynamic Changes of CD44 Expression from Progenitors to Subpopulations of Astrocytes and Neurons in Developing Cerebellum

(2013) Masae Naruse et al.   PLoS One

TSG-6 Protein Is Crucial for the Development of Pulmonary Hyaluronan Deposition, Eosinophilia, and Airway Hyperresponsiveness in a Murine Model of Asthma

(2012) Shadi Swaidani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Expression of Inter-α-inhibitor (IαI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex

(2012) Suzhen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irreversible Heavy Chain Transfer to Hyaluronan Oligosaccharides by Tumor Necrosis Factor-stimulated Gene-6

(2012) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan and Hyaluronan Binding Proteins Are Normal Components of Mouse Pancreatic Islets and Are Differentially Expressed by Islet Endocrine Cell Types

(2012) Rebecca L. Hull et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

The Inflammation-associated Protein TSG-6 Cross-links Hyaluronan via Hyaluronan-induced TSG-6 Oligomers

(2011) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TSG-6 Protein, a Negative Regulator of Inflammatory Arthritis, Forms a Ternary Complex with Murine Mast Cell Tryptases and Heparin

(2011) Gyorgy Nagyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration

(2011) Stephen P. Evanko et al.   MATRIX BIOLOGY

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors

(2011) P. L. Bollyky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin

(2010) David J. Mahoney et al.   ARTHRITIS AND RHEUMATISM

Identification of CD44 as a cell surface marker for Müller glia precursor cells

(2010) Toru Shinoe et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin

(2010) KT Tan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

(2010) J. Y. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Inflammatory Cytokines IL-1β and TNF-α Regulate p75NTR Expression in CNS Neurons and Astrocytes by Distinct Cell-Type-Specific Signalling Mechanisms

(2009) Soyoung Choi et al.   ASN Neuro

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor

(2009) Andrea B. Cragnolini et al.   GLIA

Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions

(2009) A. Marson et al.   GLYCOBIOLOGY

Biochemical Characterization and Function of Complexes Formed by Hyaluronan and the Heavy Chains of Inter-α-inhibitor (HC·HA) Purified from Extracts of Human Amniotic Membrane

(2009) Hua He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells

(2009) Paul L. Bollyky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6

(2009) Virginia Maina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation

(2008) David J. Mahoney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Adult bone marrow-derived mononuclear cells expressing chondroitinase AC transplanted into CNS injury sites promote local brain chondroitin sulphate degradation

(2008) Yvette M. Coulson-Thomas et al.   JOURNAL OF NEUROSCIENCE METHODS

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY