Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

(2016) Leia C. Shuhaibar et al.   DEVELOPMENTAL BIOLOGY

Acromesomelic dysplasia, type maroteaux caused by novel loss-of-function mutations of the NPR2 gene: Three case reports

(2015) Wei Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Gene as a Cause of Short Stature

(2015) Sophie R. Wang et al.   HUMAN MUTATION

HeterozygousNPR2Mutations Cause Disproportionate Short Stature, Similar to Léri-Weill Dyschondrosteosis

(2015) Alfonso Hisado-Oliva et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

N-linked sugar-regulated protein folding and quality control in the ER

(2015) Abla Tannous et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification and Functional Characterization of Two NovelNPR2Mutations in Japanese Patients With Short Stature

(2014) Naoko Amano et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene

(2013) Kohji Miura et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B

(2013) Jerid W. Robinson et al.   BONE

An Activating Mutation in the Kinase Homology Domain of the Natriuretic Peptide Receptor-2 Causes Extremely Tall Stature Without Skeletal Deformities

(2013) Sabine E. Hannema et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Gene as a Cause of Short Stature in Patients Initially Classified as Idiopathic Short Stature

(2013) Gabriela A. Vasques et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel mutations in natriuretic peptide receptor-2 gene underlie acromesomelic dysplasia, type maroteaux

(2012) Saadullah Khan et al.   BMC Medical Genetics

A Functional Screen Provides Evidence for a Conserved, Regulatory, Juxtamembrane Phosphorylation Site in Guanylyl Cyclase A and B

(2012) Andrea R. Yoder et al.   PLoS One

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

(2012) Kohji Miura et al.   PLoS One

Guanylyl Cyclases A and B Are Asymmetric Dimers That Are Allosterically Activated by ATP Binding to the Catalytic Domain

(2012) J. W. Robinson et al.   Science Signaling

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

Natriuretic peptide metabolism, clearance and degradation

(2011) Lincoln R. Potter   FEBS Journal

ATP Potentiates Competitive Inhibition of Guanylyl Cyclase A and B by the Staurosporine Analog, Gö6976

(2011) Jerid W. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass Spectrometric Identification of Phosphorylation Sites in Guanylyl Cyclase A and B

(2010) Andrea R. Yoder et al.   BIOCHEMISTRY

Prolonged Atrial Natriuretic Peptide Exposure Stimulates Guanylyl Cyclase-A Degradation

(2010) Darcy R. Flora et al.   ENDOCRINOLOGY

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes

(2010) M. Zhang et al.   SCIENCE

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux

(2008) A. N. Hume et al.   HUMAN MOLECULAR GENETICS