Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

(2016) A. J. Hinrich et al.   EMBO Molecular Medicine

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear

(2016) X.-N. Zhu et al.   JOURNAL OF NEUROSCIENCE

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

Reelin and Neuropsychiatric Disorders

(2016) Kazuhiro Ishii et al.   Frontiers in Cellular Neuroscience

Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration

(2016) April L. Lussier et al.   Frontiers in Cellular Neuroscience

Seizure-Induced Motility of Differentiated Dentate Granule Cells Is Prevented by the Central Reelin Fragment

(2016) Catarina Orcinha et al.   Frontiers in Cellular Neuroscience

New Insights into Reelin-Mediated Signaling Pathways

(2016) Gum Hwa Lee et al.   Frontiers in Cellular Neuroscience

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

(2016) Sumasri Guntupalli et al.   NEURAL PLASTICITY

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

(2016) Jonathan J. Sabbagh et al.   Frontiers in Neuroscience

LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation

(2015) Francesca Telese et al.   NEURON

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway

(2014) Jorge A Larios et al.   BMC NEUROSCIENCE

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

(2014) Courtney Lane-Donovan et al.   NEURON

Sorting Nexin 17 Regulates ApoER2 Recycling and Reelin Signaling

(2014) Pablo Sotelo et al.   PLoS One

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

(2014) C. R. Wasser et al.   Science Signaling

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy

(2013) Stefanie Tinnes et al.   FASEB JOURNAL

ApoER2 processing by presenilin-1 modulates reelin expression

(2013) Valeria Balmaceda et al.   FASEB JOURNAL

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

(2013) S. Kocherhans et al.   JOURNAL OF NEUROSCIENCE

Tyrosine phosphatase STEP61negatively regulates amyloid β-mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors

(2013) Lin Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain-Derived Neurotrophic Factor Induces Matrix Metalloproteinase 9 Expression in Neurons via the Serum Response Factor/c-Fos Pathway

(2013) B. Kuzniewska et al.   MOLECULAR AND CELLULAR BIOLOGY

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

(2013) J Iafrati et al.   MOLECULAR PSYCHIATRY

Hippocampus-Related Cognitive Impairments in Young apoE4 Targeted Replacement Mice

(2013) Shiran Salomon-Zimri et al.   Neurodegenerative Diseases

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission

(2013) Manjot Bal et al.   NEURON

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

(2013) X. Chen et al.   NEUROSCIENCE

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

The involvement of Reelin in neurodevelopmental disorders

(2012) Timothy D. Folsom et al.   NEUROPHARMACOLOGY

Role for Reelin in Neurotransmitter Release

(2011) S. Hellwig et al.   JOURNAL OF NEUROSCIENCE

Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex

(2011) Yves Jossin et al.   NATURE NEUROSCIENCE

Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats

(2011) Jan Brosda et al.   NEUROBIOLOGY OF DISEASE

ApoE Receptor 2 Regulates Synapse and Dendritic Spine Formation

(2011) Sonya B. Dumanis et al.   PLoS One

Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning

(2010) Stefanie Tinnes et al.   FASEB JOURNAL

Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation

(2010) J. Leemhuis et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

(2010) Irene Knuesel   PROGRESS IN NEUROBIOLOGY

Role for Reelin in stabilizing cortical architecture

(2010) Michael Frotscher   TRENDS IN NEUROSCIENCES

Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling

(2009) Toshifumi Morimura et al.   BRAIN RESEARCH

The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement

(2009) S. Sakura Minami et al.   FASEB JOURNAL

Differential Functions of ApoER2 and Very Low Density Lipoprotein Receptor in Reelin Signaling Depend on Differential Sorting of the Receptors

(2009) Sarah Duit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Reelin Secreted by GABAergic Neurons Regulates Glutamate Receptor Homeostasis

(2009) Cecilia Gonzalez Campo et al.   PLoS One

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin deficiency causes granule cell dispersion in epilepsy

(2009) Carola A. Haas et al.   EXPERIMENTAL BRAIN RESEARCH

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

(2008) T. Matsuki et al.   JOURNAL OF CELL SCIENCE

The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons

(2008) S. Niu et al.   JOURNAL OF NEUROSCIENCE

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

(2008) Maria-Paz Marzolo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Age-related accumulation of Reelin in amyloid-like deposits

(2007) Irene Knuesel et al.   NEUROBIOLOGY OF AGING