CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal

CD6 modulates thymocyte selection and peripheral T cell homeostasis

(2016) Marc Orta-Mascaró et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C5a inhibitor protects against ischemia/reperfusion injury in rat small intestine

(2016) Eszter Tuboly et al.   MICROBIOLOGY AND IMMUNOLOGY

Itolizumab in combination with methotrexate modulates active rheumatoid arthritis: safety and efficacy from a phase 2, randomized, open-label, parallel-group, dose-ranging study

(2015) Arvind Chopra et al.   CLINICAL RHEUMATOLOGY

Natural IgM Prevents Autoimmunity by Enforcing B Cell Central Tolerance Induction

(2015) Trang T. T. Nguyen et al.   JOURNAL OF IMMUNOLOGY

Long-term efficacy and safety of itolizumab in patients with moderate-to-severe chronic plaque psoriasis: A double-blind, randomized-withdrawal, placebo-controlled study

(2015) Sunil Dogra et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, phase-III study

(2014) D.S. Krupashankar et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice

(2014) Nichol E. Holodick et al.   Frontiers in Immunology

CD6 as a Therapeutic Target in Autoimmune Diseases: Successes and Challenges

(2013) Mafalda Pinto et al.   BIODRUGS

New insights in intestinal ischemia–reperfusion injury

(2013) Kaatje Lenaerts et al.   Current Opinion in Organ Transplantation

Protective Role of p70S6K in Intestinal Ischemia/Reperfusion Injury in Mice

(2012) Kechen Ban et al.   PLoS One

Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice

(2012) Melissa J. Watson et al.   SURGERY

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

(2011) Tin Kyaw et al.   CIRCULATION RESEARCH

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

(2011) Marta I. Oliveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B-1 cells in the bone marrow are a significant source of natural IgM

(2011) Youn Soo Choi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity

(2011) Emilie Domange Jordö et al.   MOLECULAR IMMUNOLOGY

Human Intestinal Ischemia-Reperfusion–Induced Inflammation Characterized

(2010) Joep Grootjans et al.   AMERICAN JOURNAL OF PATHOLOGY

Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction

(2010) M. S. Haas et al.   CARDIOVASCULAR RESEARCH

CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction

(2010) P. Nair et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells

(2010) Nichol E. Holodick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aberrant expression of CD6 on B-cell subsets from patients with Sjögren’s syndrome

(2010) Ruby Alonso et al.   JOURNAL OF AUTOIMMUNITY

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

(2010) Brigitte Vollmar et al.   LANGENBECKS ARCHIVES OF SURGERY

Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury

(2009) L. Kulik et al.   JOURNAL OF IMMUNOLOGY

ELIMINATION OF C5AR PREVENTS INTESTINAL MUCOSAL DAMAGE AND ATTENUATES NEUTROPHIL INFILTRATION IN LOCAL AND REMOTE ORGANS

(2009) Da-Zhong Xu et al.   SHOCK

IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice

(2008) Colin Edgerton et al.   CLINICAL IMMUNOLOGY

Human natural IgM can induce ischemia/reperfusion injury in a murine intestinal model

(2008) Ming Zhang et al.   MOLECULAR IMMUNOLOGY