Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle

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Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter

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Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

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MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

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Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

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Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

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Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

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The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

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The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

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Calcium Movement in Cardiac Mitochondria

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Junctional Cleft [Ca 2+ ] i Measurements Using Novel Cleft-Targeted Ca 2+ Sensors

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MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

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Reconstitution of the mitochondrial calcium uniporter in yeast

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MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Kissing and nanotunneling mediate intermitochondrial communication in the heart

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EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

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MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

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Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

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Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

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Measuring Local Gradients of Intramitochondrial [Ca 2+ ] in Cardiac Myocytes During Sarcoplasmic Reticulum Ca 2+ Release

(2012) Xiyuan Lu et al.   CIRCULATION RESEARCH

Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study

(2012) Pierre Cosson et al.   PLoS One

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points

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Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

The Effect of OPA1 on Mitochondrial Ca2+ Signaling

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Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

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High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

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Physical Coupling Supports the Local Ca2+Transfer between Sarcoplasmic Reticulum Subdomains and the Mitochondria in Heart Muscle

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Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

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