Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility

(2014) Allan Joaquim Lamontanara et al.   Nature Communications

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains

(2013) F. Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

(2012) O. Hantschel et al.   CANCER RESEARCH

Structural insights for engineering binding proteins based on non-antibody scaffolds

(2012) Ryan N Gilbreth et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

(2011) Florian Grebien et al.   CELL

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

(2011) Akiko Koide et al.   JOURNAL OF MOLECULAR BIOLOGY

BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib

(2010) D. W. Sherbenou et al.   BLOOD

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

(2010) John Wojcik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accelerating phage-display library selection by reversible and site-specific biotinylation

(2009) A. Koide et al.   PROTEIN ENGINEERING DESIGN & SELECTION

ProtorP: a protein-protein interaction analysis server

(2008) C. Reynolds et al.   BIOINFORMATICS

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

(2008) Panagis Filippakopoulos et al.   CELL

The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia

(2008) Oliver Hantschel et al.   Molecular Oncology