Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Oncology
Huohuan Tian, Linhui Yang, Wang Hou, Yu Wu, Yang Dai, Jiang Yu, Dan Liu
Summary: This article describes a rare and life-threatening case of acute promyelocytic leukemia (APL) occurring during the management of lung cancer, mainly caused by chemoradiotherapy. The case presented a patient who developed thrombocytopenia after receiving oral osimertinib in combination with intensity-modulated radiotherapy (IMRT). The patient exhibited unrecoverable abnormalities in routine blood tests, which progressed to hematological malignancy later identified as therapy-related APL (t-APL). Therefore, hematological assessment should be conducted for patients undergoing EGFR-TKI combined with local radiotherapy, and if unrecoverable abnormalities are observed, treatment for a secondary nonsolid malignancy should be considered, and further lung cancer treatment should be discontinued.
FRONTIERS IN ONCOLOGY
(2023)
Review
Hematology
Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama
Summary: This review introduced the mechanistic insights on the mobilization of hematopoietic stem cells (HSCs) induced by granulocyte colony-stimulating factor (G-CSF) from the aspect of the sympathetic nervous system (SNS). Recent findings reveal the balance between promotion and suppression pathways regulated by the SNS determines the efficiency of mobilization. Understanding the regulatory mechanisms of G-CSF-induced mobilization and its clinical implications can aid in the treatment and research of hematopoietic stem cells.
CURRENT OPINION IN HEMATOLOGY
(2023)
Article
Biology
Yang Zhou, Leqing Cao, Huidong Guo, Yan Hong, Ming Wang, Ke Wang, Xiaojun Huang, Yingjun Chang
Summary: Our study demonstrates that G-CSF-primed donor T cells have a protective effect against acute graft-versus-host disease (aGVHD) in specific target organs, particularly in the lung and gut. This protection is associated with increased Th2 cells and regulatory T cells in these organs, as well as inhibition of ICOS expression and upregulation of tolerance-related genes. The immune regulatory effects of G-CSF on T cell-mediated aGVHD, especially in GVHD target organs, provide new insights for potential therapeutic strategies.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Veterinary Sciences
Yanglong Li, Xianji Piao, Tiance Xu, Binbin Zhang, Xionghu Shen, Xian Wu Cheng, Shengzhe Zheng
Summary: G-CSF may protect the brain from injury in intracerebral hemorrhage by attenuating the expressions of TNF-α, IL-6, iNOS, and COX-2.
EXPERIMENTAL ANIMALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Takamatsu, Kotaro Yoshida, Fumihito Toshima, Kazuto Kozaka, Naho Yamamoto, Yoshimichi Sai, Toshifumi Gabata
Summary: This study aims to clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. The results of the study found that the incidence of pegfilgrastim-induced aortitis may be higher than previously reported and may be more common in patients with esophageal cancer and those who received specific anticancer drugs. Furthermore, CT findings indicated that pegfilgrastim-induced aortitis is often characterized by involvement of the aortic arch and proximal branches.
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Multidisciplinary Sciences
Tanya J. Lupancu, Kevin M. C. Lee, Mahtab Eivazitork, Cecil Hor, Andrew J. Fleetwood, Andrew D. Cook, Moshe Olshansky, Stephen J. Turner, Richard de Steiger, Keith Lim, John A. Hamilton, Adrian A. Achuthan
Summary: Glucocorticoids can suppress GM-CSF-mediated upregulation of IRF4 and CCL17 expression by regulating the expression and activity of JMJD3. Treatment with GCs inhibits CCL17 expression and improves arthritic pain-like behavior and disease in mouse models of inflammatory arthritis. This pathway provides new therapeutic options for the treatment of inflammatory conditions where GCs are used as an anti-inflammatory drug.
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Swetha Rajendran, Srikanth Swamy Swaroop, Joydeep Roy, Ezhil Inemai, Sowmiya Murugan, Suresh K. Rayala, Ganesh Venkatraman
Summary: This review provides a brief overview of the multiple mechanisms that may lead to tamoxifen resistance, with a focus on the oncogenic kinase-PAK1. Analysis of genomic data sets reveals that PAK1 gene amplification significantly affects the Relapse Free Survival of ER+ breast cancer patients. The study summarizes various mass spectrometry-based proteomic approaches for studying the specific phosphoproteomic landscape of PAK1 in tamoxifen resistance and suggests that deciphering the multiple mechanisms by which PAK1 promotes tamoxifen resistance could lead to the discovery of druggable targets and biomarkers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Veena Kumari Vuttaradhi, Inemai Ezhil, Divya Ramani, Rahul Kanumuri, Swetha Raghavan, Vaishnavi Balasubramanian, Roshni Saravanan, Archana Kanakarajan, Leena Dennis Joseph, Ravi Shankar Pitani, Sandhya Sundaram, Anita Sjolander, Ganesh Venkatraman, Suresh Kumar Rayala
Summary: This study reveals the significant role of PELP1 in inflammation-induced oncogenesis and its expression regulation through specific transcriptional control by c-Rel. Additionally, overexpression of PELP1 in macrophages promotes cancer progression through paracrine secretion. These findings underscore the connection between PELP1 and inflammation-driven tumor development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Hematology
Chonghe Zhang, Hao He, Jianing Dai, Yunxia Li, Jing He, Wu Yang, Jialin Dai, Feng Han, Wenyan Kong, Xiaohong Wang, Xiangjian Zheng, Jing Zhou, Weijun Pan, Zhongwen Chen, Singhal Mahak, Yaoyang Zhang, Feng Guo, Junhao Hu
Summary: This study reveals a novel role for KANK4 in arteriogenesis in response to ischemia. KANK4 links VEGFR2 to TALIN-1, resulting in enhanced VEGFR2 activation and increased EC proliferation, highlighting that KANK4 is a potential therapeutic target for promoting arteriogenesis for arterial occlusive diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Oncology
Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B. Shnerb, Sooraj Mathukkada, Jebrane Bouaoud, Lucas Michon, Ofra Novoplansky, Mai Badarni, Limor Cohen, Ksenia M. Yegodayev, Sapir Tzadok, Barak Rotblat, Libor Brezina, Andreas Mock, Andy Karabajakian, Jerome Fayette, Idan Cohen, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Elena Voronov, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Luc G. T. Morris, Pierre Saintigny, Moshe Elkabets
Summary: In head and neck cancer, treatment with MEK1/2 inhibitor delays tumor progression and enhances antitumor immunity of CD8(+) T cells. Sensitizing tumors to immunotherapy during MEK1/2 inhibition can eliminate tumors and induce immune memory. Prolonged treatment with MEK1/2 inhibitor may lead to immunosuppressive tumor microenvironment due to epithelial to mesenchymal transition.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Jebrane Bouaoud, Paolo Bossi, Moshe Elkabets, Sandra Schmitz, Leon C. van Kempen, Pierre Martinez, Sankar Jagadeeshan, Ingrid Breuskin, Gerwin J. Puppels, Caroline Hoffmann, Keith D. Hunter, Christian Simon, Jean-Pascal Machiels, Vincent Gregoire, Chloe Bertolus, Ruud H. Brakenhoff, Senada Koljenovic, Pierre Saintigny
Summary: Oral cavity is a common site for cancer, with the main causes being tobacco and alcohol consumption. Oral leukoplakia is the most common oral potentially malignant disorder, which can transform into oral cancer. However, there is currently no effective intervention to prevent this transformation. In this article, experts discuss the challenges in oral cancer prevention, including the need for a new classification system, better identification of high-risk patients, and the development of treatment strategies.
Review
Oncology
Ofra Novoplansky, Sankar Jagadeeshan, Ohad Regev, Idan Menashe, Moshe Elkabets
Summary: This meta-analysis study found that HRAS mutations are more prevalent in oral cavity and salivary gland tumors, while NRAS mutations are mainly found in nasopharyngeal tumors. In addition, there is a significant association between HRAS mutations and higher tumor stages, as well as a higher occurrence of KRAS mutations in HPV-positive patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Roshni Saravanan, Vaishnavi Balasubramanian, Srikanth Swamy Swaroop Balamurugan, Inemai Ezhil, Zeba Afnaan, Jisha John, Sandhya Sundaram, Shanmugasundaram Gouthaman, Suresh B. Pakala, Suresh Kumar Rayala, Ganesh Venkatraman
Summary: Breast cancer, especially triple negative breast cancer (TNBC), is a major contributor to the global cancer burden. Zinc and zinc transporters play a crucial role in the prognosis and treatment of breast cancer. LIV1, a zinc transporter, has been identified as a key target for breast cancer prognosis and emerging treatment options. Early clinical trial results show that an antibody-drug conjugate targeting LIV1 can reduce tumor burden and induce immune responses, offering promise for TNBC patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Priyanshu Sharma, Poonam Yadav, Sandhya Sundaram, Ganesh Venkatraman, Amal Kanti Bera, Devarajan Karunagaran
Summary: This study reveals, for the first time, the role of HMGB3 in the regulation of autophagy and apoptosis in breast cancer cells, and it has therapeutic implications.
Article
Oncology
Vishnupriya Kanakaveti, Sakthivel Ramasamy, Rahul Kanumuri, Vaishnavi Balasubramanian, Roshni Saravanan, Inemai Ezhil, Ravishankar Pitani, Ganesh Venkatraman, Suresh Kumar Rayala, M. Michael Gromiha
Summary: This study identified three novel BH4 mimetics that exhibit nanomolar activities against triple-negative breast cancer cells. These compounds induce apoptosis and have high specificity towards cancer cells. They show promising potential for clinical translation in targeting this challenging subtype of breast cancer.
Article
Oncology
Lavinia Arseni, Rakesh Sharma, Norman Mack, Deepthi Nagalla, Sibylle Ohl, Thomas Hielscher, Mahak Singhal, Robert Pilz, Hellmut Augustin, Roger Sandhoff, Christel Herold-Mende, Bjoern Tews, Peter Lichter, Martina Seiffert
Summary: A better understanding of tumor-stroma crosstalk and the role of sphingosine-1-phosphate (S1P) in mediating this crosstalk is crucial for the development of therapeutic approaches for human glioma. This study shows that higher levels of S1P result in an anti-inflammatory environment and inhibition of S1P signaling improves the anti-tumor response and overall survival in glioblastoma. These findings highlight the potential of targeting S1P as a therapeutic strategy.
Article
Oncology
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben-Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M. Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L. Ho, Ari J. Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R. Grandis, J. Silvio Gutkind, Moshe Elkabets
Summary: The presence of mutated HRAS in head and neck cancer patients is associated with poor prognosis and high metastasis rate. Mutated HRAS promotes cancer cell invasion and metastasis by suppressing the Hippo pathway and promoting AXL expression. The use of tipifarnib, a farnesyltransferase inhibitor, can activate the Hippo pathway, suppress metastasis, and regulate angiogenesis in HNC.
Review
Biochemistry & Molecular Biology
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan
Summary: Ovarian cancers are a type of tumor that originates from different cells of the ovary and account for around 4% of all cancers in women worldwide. There are more than 30 identified tumor types based on cellular origins, with epithelial ovarian cancer (EOC) being the most common and deadly type. EOC can be further categorized into different subtypes. The development of ovarian cancer has long been associated with endometriosis, a chronic inflammation leading to the accumulation of mutations. Recent studies have elucidated the role of somatic mutations and their impact on altered tumor metabolism. Several oncogenes and tumor suppressor genes have been implicated in ovarian cancer progression. This review highlights the genetic alterations and their impact on metabolic networks in ovarian cancer, providing insights into potential personalized therapies.
Review
Biochemistry & Molecular Biology
Sankar Jagadeeshan, Ofra Z. Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J. Rosenberg, Jennifer R. Grandis, Moshe Elkabets
Summary: This article reviews the alterations and pathway activations of RAS genes in head and neck cancer (HNC), highlighting their role in HNC initiation, progression, and metastasis. The intrinsic role of mutated-RAS in tumor cell signaling and its extrinsic role in determining tumor microenvironment (TME) heterogeneity are discussed. Furthermore, the article summarizes the impact of RAS alterations on therapy resistance and explores the potential of targeting RAS as a single agent or in combination with other therapeutic agents for HNC patients with RAS-activated tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Ofra Novoplansky, Avital B. Shnerb, Divyasree Marripati, Sankar Jagadeeshan, Raghda Abu Shareb, Cristina Conde-Lopez, Jonathan Zorea, Manu Prasad, Talal Ben Lulu, Ksenia M. Yegodayev, Chen Benafsha, Yushi Li, Dexin Kong, Fengshen Kuo, Luc G. T. Morris, Ina Kurth, Jochen Hess, Moshe Elkabets
Summary: Blocking the MAPK pathway with trametinib has shown promise in HNSCC patients. However, trametinib treatment leads to overexpression and activation of EGFR, which reduces its efficacy. The study demonstrates that blocking the EGFR/PI3K pathway is necessary to improve trametinib efficacy in HNSCC.
MOLECULAR ONCOLOGY
(2023)
Article
Biology
Assaf Nahum, Yoni Koren, Bar Ergaz, Sari Natan, Gad Miller, Yuval Tamir, Shahar Goren, Avraham Kolel, Sankar Jagadeeshan, Moshe Elkabets, Ayelet Lesman, Assaf Zaritsky
Summary: A computational method has been developed to quantify long-range cell-cell force transmission through the extracellular matrix by analyzing ECM remodeling fluctuations. This method can define unique signatures that can distinguish between different pairs of communicating cells. The method has been validated using simulations and live 3D imaging, and can detect mechanical propagation even in cases where visible fibrous bands are not formed. The ability to infer cell-ECM-cell communication using standard confocal microscopy holds great promise for wide use and democratization of the method.
COMMUNICATIONS BIOLOGY
(2023)
