The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis

Resident CAPS on dense-core vesicles docks and primes vesicles for fusion

(2016) Greg Kabachinski et al.   MOLECULAR BIOLOGY OF THE CELL

PI(4,5)P2-binding effector proteins for vesicle exocytosis

(2015) Thomas F.J. Martin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons

(2015) Margherita Farina et al.   eLife

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

The PH Domain of Phosphoinositide-Dependent Kinase-1 Exhibits a Novel, Phospho-Regulated Monomer–Dimer Equilibrium with Important Implications for Kinase Domain Activation: Single-Molecule and Ensemble Studies

(2013) Brian P. Ziemba et al.   BIOCHEMISTRY

PRIP (Phospholipase C-related but Catalytically Inactive Protein) Inhibits Exocytosis by Direct Interactions with Syntaxin 1 and SNAP-25 through Its C2 Domain

(2013) Zhao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent Activator Protein for Secretion 1 (CAPS1) Binds to Syntaxin-1 in a Distinct Mode from Munc13-1

(2013) Leon Parsaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CAPS1 Deficiency Perturbs Dense-Core Vesicle Trafficking and Golgi Structure and Reduces Presynaptic Release Probability in the Mouse Brain

(2013) T. Sadakata et al.   JOURNAL OF NEUROSCIENCE

CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis

(2013) Greg Kabachinski et al.   MOLECULAR BIOLOGY OF THE CELL

CAPS and Munc13: CATCHRs that SNARE Vesicles

(2013) Declan J. James et al.   Frontiers in Endocrinology

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold

(2012) Benjamin Stieglitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-molecule pull-down for studying protein interactions

(2012) Ankur Jain et al.   Nature Protocols

Munc13 Homology Domain-1 in CAPS/UNC31 Mediates SNARE Binding Required for Priming Vesicle Exocytosis

(2011) Chuenchanok Khodthong et al.   Cell Metabolism

Ca2+-independent syntaxin binding to the C2B effector region of synaptotagmin

(2011) Toshio Masumoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

Dysferlin Forms a Dimer Mediated by the C2 Domains and the Transmembrane Domain In Vitro and in Living Cells

(2011) Li Xu et al.   PLoS One

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

(2011) Wei Li et al.   STRUCTURE

Tethering Factors as Organizers of Intracellular Vesicular Traffic

(2010) I-Mei Yu et al.   Annual Review of Cell and Developmental Biology

UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons

(2010) Xian-Guang Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Interactions of CAPS (Ca2+-dependent Activator Protein for Secretion) with the Three Neuronal SNARE Proteins Required for Vesicle Fusion

(2010) Neil J. Daily et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two distinct secretory vesicle–priming steps in adrenal chromaffin cells

(2010) Yuanyuan Liu et al.   JOURNAL OF CELL BIOLOGY

CORAL: aligning conserved core regions across domain families

(2009) Jessica H. Fong et al.   BIOINFORMATICS

Size and Shape of Protein Molecules at the Nanometer Level Determined by Sedimentation, Gel Filtration, and Electron Microscopy

(2009) Harold P. Erickson   BIOLOGICAL PROCEDURES ONLINE

CAPS Activity in Priming Vesicle Exocytosis Requires CK2 Phosphorylation

(2009) Mari Nojiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions

(2009) D. J. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons

(2008) Marc Hammarlund et al.   JOURNAL OF CELL BIOLOGY

CAPS Facilitates Filling of the Rapidly Releasable Pool of Large Dense-Core Vesicles

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion

(2008) R. Friedrich et al.   JOURNAL OF NEUROSCIENCE