Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Lucija Mandic, Anja Sadzak, Suzana Segota
Summary: Neurodegenerative diseases are a major cause of disability and death worldwide, with pathways involving transcription factors playing a critical role in the pathological changes associated with oxidative stress and neuroinflammation. This review focuses on the role of transcription factor p53 in coordinating cellular response and potential therapeutic interventions using natural polyphenolic compounds with anti-oxidative, anti-inflammatory and anti-apoptotic effects. Further research is needed to fully understand the cellular and molecular mechanisms of these compounds for potential new treatments for neurodegenerative diseases.
Article
Respiratory System
Nan Yang, Gurpreet K. Singhera, Yi Xuan Yan, Michael P. Pieper, Janice M. Leung, Don D. Sin, Delbert R. Dorscheid
Summary: The LABA olodaterol has been shown to inhibit airway inflammation caused by RSV through its binding to the beta 2-adrenergic receptor, with a more significant effect in patients with COPD.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Federica Tonolo, Alessandra Folda, Valeria Scalcon, Oriano Marin, Alberto Bindoli, Maria Pia Rigobello
Summary: This study found that the bioactive peptides K-8-K and S-10-S, derived from milk and soy, have both antioxidant and anti-inflammatory effects in human cells. They exert antioxidant effects through activation of the Keap1/Nrf2 pathway and exert anti-inflammatory effects by inhibiting the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Onofrio Laselva, Caterina Allegretta, Sante Di Gioia, Carlo Avolio, Massimo Conese
Summary: DMF demonstrates anti-inflammatory and antioxidant effects in CF treatment, reducing inflammatory responses, restoring CFTR function, and potentially serving as a novel drug to ameliorate lung inflammation in CF patients and enhance drug efficacy.
Article
Plant Sciences
Liying Wang, Jinpo Gu, Mingyue Zong, Qingran Zhang, Huixiang Li, Danna Li, Xiaofeng Mou, Pan Liu, Yanan Liu, Feng Qiu, Feng Zhao
Summary: The study aimed to investigate the anti-inflammatory activities and molecular mechanism of physalin A. Results showed that the anti-inflammatory action of physalin A is due to the inactivation of NF-kappa B signal pathway, but is irrelevant to the MAPKs pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Pathanin Chantree, Pongsakorn Martviset, Nattaya Thongsepee, Kant Sangpairoj, Phornphan Sornchuer
Summary: This study investigated the anti-inflammatory effect of garcinol isolated from Garcinia dulcis fruit in LPS-activated THP-1 and Raw 264.7 macrophages. The results showed that garcinol inhibited the production of pro-inflammatory cytokines and mediators and affected the NF-kappa B signaling pathway. Therefore, garcinol has the potential to be used as an anti-inflammatory agent for inflammation-related diseases.
Article
Biochemistry & Molecular Biology
Marija Stankovic, Katarina Veljovic, Nikola Popovic, Snezana Kojic, Sofija Dunjic Manevski, Dragica Radojkovic, Natasa Golic
Summary: Bronchial epithelial cells are exposed to environmental influences, microbiota, and pathogens and initiate inflammation. Recent studies have found that lung microbiota differ between inflammatory lung diseases and healthy lungs, indicating their contribution to lung immunity. This study investigated the anti-inflammatory effects of 21 natural LAB strains in LPS-stimulated human bronchial epithelial cells (BEAS-2B). The results showed that several LAB strains reduced the expression of pro-inflammatory cytokine and chemokine genes. Two LAB strains, Lactobacillus brevis BGZLS10-17 and Lb. plantarum BGPKM22, effectively attenuated LPS-induced NF-kappa B nuclear translocation and the activation of p38, ERK, and JNK signaling cascade, resulting in a reduction of pro-inflammatory mediator expressions in BEAS-2B cells. These LAB strains could be used to balance immune response in lungs and replenish diminished lung microbiota in chronic lung diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ping Xu, Xiaobo Xu, Hanna Fotina, Tetiana Fotina
Summary: This study found that CGA in Taraxacum officinale can reduce the expression of inflammatory genes and proteins in mammary epithelial cells of a mastitis model. It does so by inhibiting the phosphorylation of proteins in the NF-κB signaling pathway, leading to reduced expression of TNF-α, IL-6, IL-1β, and TLR2. This suggests that CGA may be a potential agent for treating mastitis in dairy cows.
Article
Biochemistry & Molecular Biology
Taekil Eom, In-Hye Kim, Hyung-Joo Kim, YounHee Choi, Taek-Jeong Nam
Summary: The study revealed that CsEF from Calystegia soldanella has strong antioxidative and anti-inflammatory activities by regulating antioxidant enzymes and suppressing the expression of inflammatory cytokines.
Article
Food Science & Technology
Wenzhen Xu, Han Lu, Yuan Yuan, Zeyuan Deng, Liufeng Zheng, Hongyan Li
Summary: This study found that propolis and its main flavonoids have good antioxidant and anti-inflammatory effects. The flavonoids and propolis extract regulate cellular ROS levels, antioxidant enzyme activities, and inhibit the activation of NO, NOS, and NF-κB signaling pathways.
Article
Plant Sciences
Jin Kyeong Kim, Eunju Choi, Yo Han Hong, Haeyeop Kim, Young-Jin Jang, Jong Sub Lee, Eui Su Choung, Byoung Young Woo, Yong Deog Hong, Sarah Lee, Byoung-Hee Lee, Tran The Bach, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho
Summary: The methanol extract of Melicope accedens (Ma-ME) demonstrated anti-inflammatory properties by targeting Syk in the NF-kappa B signaling pathway, containing various anti-inflammatory flavonoids.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Xin Lin, Kenji Tago, Nozomi Okazaki, Takanori So, Kyoko Takahashi, Tadahiko Mashino, Hiroomi Tamura, Megumi Funakoshi-Tago
Summary: In this study, the newly synthesized indole-hydantoin derivative IH-1 showed significant inhibitory effects on LPS-induced inflammatory responses in murine macrophage-like cells, indicating its potential as an anti-inflammatory drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jinbang Xiao, Shanshan Li, Ruixue Zhang, Zongjie Wang, Xinyan Zhang, Aihua Wang, Yaping Jin, Pengfei Lin
Summary: Endometritis is a common reproductive disease in domestic animals caused by Gram-negative bacterial infection, where the ISGylation modification system can regulate the inflammatory response by modulating the TLR4/NF-kappa B signaling pathway. Experimental evidence shows that ISG15 can inhibit LPS-induced inflammatory response through ISGylation.
Article
Pharmacology & Pharmacy
Catia Sousa, Bruno Miguel Neves, Alcino Jorge Leitao, Alexandrina Ferreira Mendes
Summary: In this study, the anti-inflammatory activity of (R)-(-)-carvone was explored. The results showed that (R)-(-)-carvone could inhibit the signaling pathways involving MAPKs and NF-kappa B. It was found that (R)-(-)-carvone significantly decreased the phosphorylation of JNK1 and inhibited the transcriptional activity of NF-kappa B. Moreover, (R)-(-)-carvone might exert its anti-inflammatory effect through the activation of Nrf2.
Review
Biochemistry & Molecular Biology
Won Young Jang, Ji Yeon Hwang, Jae Youl Cho
Summary: NF-kappa B signaling pathways contribute to inflammation and immune cell differentiation, but uncontrolled stimulation leads to inflammatory diseases. Ginsenosides from Panax ginseng have shown therapeutic efficacy in alleviating NF-kappa B responses and may be effective in treating severe inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)