Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer

Endothelial Delta-like 4 (DLL4) promotes renal cell carcinoma hematogenous metastasis

(2015) Qing Bo Huang et al.   Oncotarget

Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

(2014) C. Y. Hu et al.   CLINICAL CANCER RESEARCH

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

A clear picture of renal cell carcinoma

(2013) A Ari Hakimi et al.   NATURE GENETICS

ChromHMM: automating chromatin-state discovery and characterization

(2012) Jason Ernst et al.   NATURE METHODS

Sunitinib and other targeted therapies for renal cell carcinoma

(2011) T Powles et al.   BRITISH JOURNAL OF CANCER

Transcriptome Analysis of Human Diabetic Kidney Disease

(2011) K. I. Woroniecka et al.   DIABETES

JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation

(2011) A. Pietras et al.   MOLECULAR CANCER RESEARCH

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma

(2011) Jonas Sjölund et al.   PLoS One

Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

(2011) Hector Alvarez et al.   PLoS Genetics

Repeat element-driven activation of proto-oncogenes in human malignancies

(2010) Björn Lamprecht et al.   CELL CYCLE

High Jagged1 Expression Predicts Poor Outcome in Clear Cell Renal Cell Carcinoma

(2010) Kerong Wu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

(2009) M. E. Figueroa et al.   BLOOD

Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2

(2009) Kuicheon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

(2009) Mayumi Oda et al.   NUCLEIC ACIDS RESEARCH

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

(2008) Jonas Sjölund et al.   JOURNAL OF CLINICAL INVESTIGATION

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE

An Integrative Genomic and Epigenomic Approach for the Study of Transcriptional Regulation

(2008) Maria E. Figueroa et al.   PLoS One