TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin

Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle

(2015) S. K. Powell et al.   EMBO JOURNAL

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

(2014) Nicole B Averbeck et al.   CELL CYCLE

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Impaired p32 Regulation Caused by the Lymphoma-Prone RECQ4 Mutation Drives Mitochondrial Dysfunction

(2014) Jiin-Tarng Wang et al.   Cell Reports

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases

(2013) Mariko Moritani et al.   JOURNAL OF BIOCHEMISTRY

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

(2013) Armin M. Gamper et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

The many facets of the Tim-Tipin protein families’ roles in chromosome biology

(2011) Ramsay J. McFarlane et al.   CELL CYCLE

Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts

(2011) Stephanie L. Smith-Roe et al.   CELL CYCLE

Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2–7 Complex, Allowing the GINS Tetramer to Bind the Mcm2–7 Complex

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2–7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA

(2011) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of the Cdc6 replication licensing factor in metazoa: The role of nuclear export and the CUL4 ubiquitin ligase

(2010) Jihyun Kim et al.   CELL CYCLE

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27Kip1concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3

(2010) Xuening Wang et al.   CELL CYCLE

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

Cohesin organizes chromatin loops at DNA replication factories

(2010) E. Guillou et al.   GENES & DEVELOPMENT

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb

(2010) Yuki Numata et al.   JOURNAL OF BIOCHEMISTRY

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

(2010) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion

(2010) A. R. Leman et al.   JOURNAL OF CELL SCIENCE

Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation

(2010) S. Thangavel et al.   MOLECULAR AND CELLULAR BIOLOGY

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Perspectives in Cell Cycle Regulation: Lessons from an Anoxic Vertebrate

(2009) Kyle Biggar et al.   CURRENT GENOMICS

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

(2009) Xiaohua Xu et al.   EMBO JOURNAL

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis

(2009) Kevin D. Smith et al.   JOURNAL OF CELL BIOLOGY

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL