Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins

Immunocytokines for cancer treatment: past, present and future

(2016) Dario Neri et al.   CURRENT OPINION IN IMMUNOLOGY

Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies

(2015) Dario Venetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase II Trial of the Anti-CD19 Bispecific T Cell–Engager Blinatumomab Shows Hematologic and Molecular Remissions in Patients With Relapsed or Refractory B-Precursor Acute Lymphoblastic Leukemia

(2014) Max S. Topp et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Emerging classes of armed antibody therapeutics against cancer

(2014) Christian Hess et al.   MedChemComm

High efficiency cell-specific targeting of cytokine activity

(2014) Geneviève Garcin et al.   Nature Communications

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit

(2013) Rashmi Jalah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new platform for constructing antibody-cytokine fusion proteins (immunocytokines) with improved biological properties and adaptable cytokine activity

(2013) S. D. Gillies   PROTEIN ENGINEERING DESIGN & SELECTION

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

(2013) L. R. Desnoyers et al.   Science Translational Medicine

The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel

(2012) N. Pasche et al.   CLINICAL CANCER RESEARCH

Immunocytokines: a novel class of potent armed antibodies

(2012) Nadine Pasche et al.   DRUG DISCOVERY TODAY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma

(2011) T. K. Eigentler et al.   CLINICAL CANCER RESEARCH

Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12

(2010) Roberto Sommavilla et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Monoclonal antibody therapies for solid tumors

(2009) Dimiter V Tassev et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Protein complementation assays: Approaches for the in vivo analysis of protein interactions

(2009) Montse Morell et al.   FEBS LETTERS

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

Site-directed mutagenesis by combination of homologous recombination and DpnI digestion of the plasmid template in Escherichia coli

(2007) Jing Li et al.   ANALYTICAL BIOCHEMISTRY