Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE

(2016) Doyel Sen et al.   NUCLEIC ACIDS RESEARCH

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

(2015) Lin Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Subunit Binding Positions on a Model Fork and Displacements That Occur during Sequential Assembly of theEscherichia coliPrimosome

(2015) Carol M. Manhart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hexameric structure of the human mitochondrial replicative helicase Twinkle

(2015) Pablo Fernández-Millán et al.   NUCLEIC ACIDS RESEARCH

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

(2015) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Members of the RAD52 Epistasis Group Contribute to Mitochondrial Homologous Recombination and Double-Strand Break Repair in Saccharomyces cerevisiae

(2015) Alexis Stein et al.   PLoS Genetics

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

Novel Function of the Fanconi Anemia Group J or RECQ1 Helicase to Disrupt Protein-DNA Complexes in a Replication Protein A-stimulated Manner

(2014) Joshua A. Sommers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

(2014) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

(2014) Kent Z.Q. Wang et al.   MITOCHONDRION

Formation and repair of oxidative damage in the mitochondrial DNA

(2014) Meltem Muftuoglu et al.   MITOCHONDRION

Organization of the human mitochondrial transcription initiation complex

(2014) Elena Yakubovskaya et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Impact of Age-Associated Cyclopurine Lesions on DNA Repair Helicases

(2014) Irfan Khan et al.   PLoS One

Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation

(2014) Huu B. Ngo et al.   Nature Communications

A Single-Molecule View of the Assembly Pathway, Subunit Stoichiometry, and Unwinding Activity of the Bacteriophage T4 Primosome (helicase–primase) Complex

(2013) Wonbae Lee et al.   BIOCHEMISTRY

Replicating animal mitochondrial DNA

(2013) Emily A. McKinney et al.   GENETICS AND MOLECULAR BIOLOGY

Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress

(2013) Jay M. Sage et al.   MITOCHONDRION

Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication

(2013) N. Rajala et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

(2013) J. L. O. Pohjoismaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

(2012) Brian R. Berquist et al.   CANCER LETTERS

Structure and Stability of Duplex DNA Containing (5′S)-5′,8-Cyclo-2′-deoxyadenosine: An Oxidatively Generated Lesion Repaired by NER

(2012) Tatiana Zaliznyak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human Mitochondrial DNA Helicase TWINKLE Is Both an Unwinding and Annealing Helicase

(2012) Doyel Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA nucleoid structure

(2011) Daniel F. Bogenhagen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Defects in mitochondrial DNA replication and human disease

(2011) William C. Copeland   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Coupling dTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7

(2011) Ajit K. Satapathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of (5′S)-8,5′-Cyclo-2′-deoxyguanosine in DNA

(2011) Hai Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

(2011) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

(2011) Brian W. Graham et al.   NUCLEIC ACIDS RESEARCH

The human mitochondrial replication fork in health and disease

(2010) Sjoerd Wanrooij et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Dynamic Effects of Cofactors and DNA on the Oligomeric State of Human Mitochondrial DNA Helicase

(2010) Tawn D. Ziebarth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Novel Function for Human Rad51

(2010) Jay M. Sage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Learning Rates and States from Biophysical Time Series: A Bayesian Approach to Model Selection and Single-Molecule FRET Data

(2009) Jonathan E. Bronson et al.   BIOPHYSICAL JOURNAL

FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and Is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner

(2009) Avvaru N. Suhasini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RECQ1 Possesses DNA Branch Migration Activity

(2008) Dmitry V. Bugreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS