Article
Chemistry, Organic
Baofu Zhu, Jiaming He, Kai Zou, Anquan Li, Chen Zhang, Jiaji Zhao, Hua Cao
Summary: This study established a three-component reaction catalyzed by base, involving ynals, isocyanates, amines, and alcohols. The strategy enables a wide range of substrates and provides a simple process for the preparation of diverse pyridine derivatives with good yields and high regioselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Burcu Alkan, Ozgun Daglar, Serter Luleburgaz, Begum Gungor, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: A novel one-pot cascade reaction was proposed for the synthesis and simultaneous modification of polyesters, utilizing the Passerini three-component reaction. The study emphasized the significance of temperature in achieving high molecular weight polymers and efficient reactions.
Article
Chemistry, Multidisciplinary
Yong Tang, Kaifu Zhang, Yuelin Xu, Jinglin Ma, Hanqing Xie, Hongquan Zhang, Yanmin Jiang, Rui Zhao, Lei Wang
Summary: A green and efficient method for the construction of functionalized 2,3-dihydrothiophene derivatives in water was reported. Novozym 435 demonstrated remarkable catalytic activity in the four-component reaction of aldehydes, malonitrile or ethyl cyanoacetate, 1,3-thiazolidinedione, and amines, resulting in excellent product yields. Furthermore, the catalyst could be reused for multiple cycles.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Faranak Manteghi, Fatemeh Zakeri, Owen James Guy, Zari Tehrani
Summary: A chromium-containing metal-organic framework MIL-101 was effectively used as a heterogeneous catalyst for the solvent-free synthesis of 2,4,5-trisubstituted imidazoles, showing advantages such as high efficiency, reusability, and ease of isolation. The catalytic reaction achieved a high yield in a short time, making it a promising alternative to other catalysts.
Article
Chemistry, Organic
Hao Liu, Meng-Ling Lin, Yin-Jun Chen, Yin-Hui Huang, Lin Dong
Summary: A Rh(iii)-catalyzed three-component C-H bond functionalization protocol has been successfully used to synthesize complex polycyclic BINOL derivatives, with the in situ formation of intermediate amides from aldehydes and amines. This high efficiency strategy allows for rapid and selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Stephany Zarate-Roldan, Maria Concepcion Gimeno, Raquel P. Herrera
Summary: The formal homogeneous gold-catalyzed A(3)-coupling reaction starting from benzyl alcohols allows for the straightforward synthesis of propargylamines. The highly valuable final products are obtained with very good yields in short reaction times, which is fundamental for pharmaceutical synthesis. The methodology's usefulness and efficiency are successfully compared against the same reaction starting from aldehydes.
Article
Chemistry, Physical
Giovanna Bosica, Riccardo De Nittis, Ryan Borg
Summary: An efficient and environmentally benign one-pot condensation reaction was achieved using 1,4-diazabicyclo[2-2-2]octane supported on Amberlyst-15 as a novel catalyst. The reaction involved cyclic diketones, aldehydes, and naphthols, resulting in the synthesis of various benzoxanthenones with good to excellent yields. The advantages of this reaction include the use of a heterogeneous catalyst, solventless conditions, atom-economical methodology, and low E-factor values. Seventeen xanthene derivatives, including two novel molecules, were synthesized and characterized. Aromatic aldehydes with electron-withdrawing groups showed excellent yields, and aliphatic aldehydes also gave appreciable results. The catalyst exhibited full recyclability and could be reused up to six times.
Article
Chemistry, Organic
Xin Wang, Jinhuan Dong, Xianxiu Xu, Bo Tang
Summary: A base-catalyzed double annulation methodology has been developed for the efficient synthesis of 4-azafluorene and 4-azafluorenone derivatives. In contrast to traditional 1,3-dipolar reactions, the active methylene and isocyano groups of isocyanoacetate function as nucleophiles in this domino transformation.
Article
Engineering, Environmental
Pierre Stiernet, Matjaz Mazaj, Sebastijan Kovacic, Antoine Debuigne
Summary: This study introduces an innovative one-pot water-mediated synthesis method for bifunctional imidazolium/amine microcellular polymer foams with tunable ratios of functional groups. The resulting polymer foams show superior CO2 capture performance compared to their monofunctional counterparts, indicating the synergy between the functional groups in a highly porous morphology.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Wei-Bao He, Sai-Jie Zhao, Jing-Yang Chen, Jun Jiang, Xiang Chen, Xinhua Xu, Wei-Min He
Summary: A practical method for the synthesis of 4-thiocyanato-1H-pyrazoles was established through an electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully achieved.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
T. Krishnaveni, M. Kaveri, K. Kadirvelu
Summary: Palladium(ii) oxide nanoparticles were prepared using a hydrothermal method with quercetin as a capping agent, which showed good catalytic activity in the synthesis of propargylamines. The catalyst exhibited high turnover number and frequency, as well as excellent recyclability for multiple cycles.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Manpreet Kaur, Mayank, Deepak Bains, Gagandeep Singh, Navneet Kaur, Narinder Singh
Summary: Efficient multicomponent tandem polymerization (MCTP) has recently become a focus of interest. Synthesis of fluorescent non-conjugated polyamide gels using a newly developed magnetic catalyst under solvent free conditions resulted in high yields of high molecular weight products. Characterization through various techniques confirmed the structure of the prepared polyamide gels, showing great potential for this simple and efficient polymerization approach.
Review
Polymer Science
In-Hwan Lee, Ki-Taek Bang, Hee-Seong Yang, Tae-Lim Choi
Summary: Diversification of polymer structures is crucial for unique applications, and diversity-oriented polymerization (DOP) using multicomponent polymerization (MCP) has emerged as an efficient strategy. Cu-catalyzed MCP (Cu-MCP) has overcome previous challenges in MCP, paving the way for diverse and complex polymer structures. Future research will focus on the advancement and optimization of Cu-MCP for innovative polymer applications.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Meng Du, Ming Li, Wangze Song, Nan Zheng
Summary: In this study, a metal-free multicomponent polymerization method was developed to synthesize water-soluble polymers with cationic properties, which are considered as promising non-viral gene carriers.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Yasser Attia Attia, Shams H. Abdel-Hafez
Summary: The efficient synthesis of transition-metal cobalt oxide nanoparticles (Co3O4 NPs) was achieved using the co-precipitation method without the use of costly and toxic solvents or complicated equipment. These reusable nanoparticles demonstrated high catalytic activity under microwave irradiation for the synthesis of organoselenium compounds with higher yields and milder reaction conditions.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Chemistry, Physical
Amjad F. Alharthi, Mohamed Gouda, Mai M. Khalaf, Abraham Elmushyakhi, Manal F. Abou Taleb, Hany M. Abd El-Lateef
Summary: In this study, multifunctional materials were synthesized by incorporating metal oxide nanoparticles into a polymer matrix for use as wound dressings. The composite material exhibited high crystallinity, uniform morphology, good thermal stability, and antibacterial activity against E. coli.
Article
Chemistry, Physical
Abdulrhman A. A. Al-Shamry, Mai M. M. Khalaf, Hany M. Abd El-Lateef, Tarek A. A. Yousef, Gehad G. G. Mohamed, Kariman M. Kamal El-Deen, Mohamed Gouda, Ahmed M. M. Abu-Dief
Summary: A Schiff base ligand was synthesized through the condensation of isatin and aniline, and a series of metal complexes derived from the ligand were characterized. The metal complexes exhibited different geometries and thermal decomposition behaviors. The metal complexes showed stronger antibacterial properties and anticancer activities compared to the ligand alone. A DFT investigation provided information on the electronic features of the ligand and its metal complexes. The drug-likeness and ADME characteristics of the compounds were also calculated.
Article
Chemistry, Physical
Mohamed Ali Ibrahim Al-Gaber, Hany M. Abd El-Lateef, Mai M. Khalaf, Saad Shaaban, Mohamed Shawky, Gehad G. Mohamed, Aly Abdou, Mohamed Gouda, Ahmed M. Abu-Dief
Summary: A new heterocyclic azo dye ligand (L) was synthesized and coordinated with various metal ions to form complexes. The structures of the complexes were determined using multiple techniques. The ligand exhibited tri-dentate behavior and coordinated to the metal ions through multiple functional groups. The complexes showed good antimicrobial activity and potential for future study.
Article
Polymer Science
Latifah Mohammed Ali Almaieli, Mai M. M. Khalaf, Mohamed Gouda, Abraham Elmushyakhi, Manal F. F. Abou Taleb, Hany M. M. Abd El-Lateef
Summary: Chitosan-metal oxide nanohybrid (MONH) composites were prepared by combining chitosan with MONH made of vanadium oxide, ytterbium trioxide, and graphene oxide to create wound dressing materials. The properties of the nanohybrid@CS were analyzed using various techniques including FTIR, XRD, SEM/EDX, and TGA. The contact angles of the composites showed a decrease when in the hydrophilic phase, indicating improved water and drug absorption. The addition of MONH also resulted in cell viability and growth.
Article
Polymer Science
Latifah Mohammed Ali Almaieli, Mai M. Khalaf, Mohamed Gouda, Sultan Alhayyani, Manal F. Abou Taleb, Hany M. Abd El-Lateef
Summary: This study focuses on wound dressings made of cellulose acetate encapsulating chromium oxide, titanium oxide, and graphene oxide. The films were characterized for their structure, morphology, optics, thermal behavior, and biological activity. The results demonstrated the promising wound-healing behavior of the cellulose acetate-based films.
Review
Biochemistry & Molecular Biology
Hany M. Abd El-Lateef, Tarek El-Dabea, Mai M. M. Khalaf, Ahmed M. M. Abu-Dief
Summary: During recent decades, the complexation of organic ligands toward several metal ions of s-p and d-block has been applied as a plan to enhance its antioxidant performance. Due to their wide range of beneficial impacts, coordination compounds are widely used in industries, specifically in the medicinal and pharmaceutical fields.
Article
Chemistry, Applied
Hany M. Abd El-Lateef, Mai M. Khalaf, Mahmoud Kandeel, Amer A. Amer, Antar A. Abdelhamid, Aly Abdou
Summary: The main purpose of this study is to design and synthesize new Co(II), Ni(II), and Cu(II) mixed-ligand complexes derived from an easily synthesized azo-ligand, [2-(phenylthio)phenyl]diazenyl}-2-naphthol (HTe), with 8-hydroxyquinoline (HQ) for antimicrobial activity evaluation. The complexes were characterized and their molecular structures were optimized using DFT calculations. The disc diffusion test showed that the prepared complexes exhibited higher antibacterial activity compared to the pristine ligands. Molecular docking studies revealed potential antibiotic properties of these complexes. The correlation between in vitro activity and DFT/molecular docking data was discussed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Agronomy
Mahmoud Kandeel, Mohamed A. A. Morsy, Hany M. M. Abd El-Lateef, Mohamed Marzok, Hossam S. S. El-Beltagi, Khalid M. M. Al Khodair, Ibrahim Albokhadaim, Katharigatta N. N. Venugopala
Summary: The B3 DNA-binding superfamily, containing a B3 domain, is involved in stress responses in Camelina sativa. A total of 87 members were identified and classified into five groups based on phylogenetic analysis. Most proteins were predicted to be located in the nucleus.
Article
Chemistry, Multidisciplinary
Hany M. Abd El-Lateef, Wafaa M. Abd El-Monem Nasr, Mai M. Khalaf, Adila E. Mohamed, Mohamed Nageeb Rashed, Mohamed Shaker S. Adam
Summary: In this study, three different Schiff base derivatives were successfully synthesized, and their corrosion inhibition effect on C1018 steel in CO2-saturated 3.5% NaCl solution was investigated. The synthesized Schiff base molecules showed outstanding corrosion inhibition effect on carbon steel at low concentrations. SEM/EDX analysis confirmed the formation of an adsorbed inhibitor film on the metal surface. Computational inspections correlated well with the experimental findings. The outcomes could have implications in assessing the efficiency of inhibiting agents in the gas and oil industry.
Article
Chemistry, Physical
Mai M. Khalaf, Hany M. Abd El-Lateef, Ibrahim M. A. Mohamed
Summary: Novel bimetallic phosphates of Mn&Ni were studied for low-cost ethylene glycol (EG) electrooxidation. The morphology, crystallinity, and chemistry of MnNiPh-Re and MnNiPh-SG were investigated, and the preparation method was found to significantly affect the observed morphology. The electrocatalytic performance of MnNiPh-Re and MnNiPh-SG as working electrodes for EG oxidation was evaluated, and MnNiPh-SG exhibited better EG oxidation compared to MnNiPh-Re at different EG contents.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Applied
Hany M. Abd El-Lateef, Mai M. Khalaf, Amer A. Amer, Antar A. Abdelhamid, Aly Abdou
Summary: The aim of this study was to synthesize and characterize new metal complexes incorporating bioactive 8-hydroxyquinoline moiety and investigate their antibacterial, antifungal, and anti-inflammatory potential. The metal complexes showed enhanced antimicrobial and anti-inflammatory properties compared to the original ligands, suggesting their potential as future antibiotics and anti-inflammatory candidates.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Hany M. Abd El-Lateef, Rasha Mohammed Saleem, Mohammed A. Bazuhair, Ali Hassan Ahmed Maghrabi, Eman Hussain Khalifa Ali, Islam Zaki, Reham E. Masoud
Summary: A new series of hydrazone derivatives were synthesized and screened for their cytotoxic activity against MCF-7 breast cancer cell line. Some compounds exhibited potent cytotoxicity and inhibition of β-tubulin. Flow cytometric analysis revealed that one compound induced cell cycle arrest at G2/M phase and increased apoptosis compared to untreated control. Molecular modeling investigations were conducted to explain the compound's exceptional cytotoxicity and superior ability to inhibit tubulin when compared to CA-4.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Hany M. Abd El-Lateef, Mai M. Khalaf, Amer A. Amer, Mahmoud Kandeel, Antar A. Abdelhamid, Aly Abdou
Summary: This study synthesized three new CrAz(2), MnAz(2), and FeAz(2) complexes and investigated their properties through various analyses. The azo-ligand, 4-(2-hydroxyphenylAzo)-1-naphthol(Az), binds with metal ions through its nitrogen and oxygen atoms. The metal complexes exhibit higher inhibitory activity against certain organisms compared to the free ligand.
Article
Chemistry, Applied
Mohamed Gouda, Yasir J. Abbas, Hany M. Abd El-Lateef, Mai M. Khalaf, Saad Shaaban
Summary: In this study, 23 naphthalene-based organoselenocyanates were synthesized and evaluated for their anticancer and antimicrobial activities. Three compounds showed pronounced anticancer activity against breast cancer cells with minimal toxicity to normal cells. Additionally, two compounds exhibited comparable cytotoxicity to an anticancer drug and demonstrated an interesting therapeutic index. Moreover, these synthesized organoselenocyanates also displayed potential antimicrobial properties against certain bacteria and yeast.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
