Article
Cardiac & Cardiovascular Systems
Marco Witkowski, Mario Witkowski, Julian Friebel, Jennifer A. Buffa, Xinmin S. Li, Zeneng Wang, Naseer Sangwan, Lin Li, Joseph A. DiDonato, Caroline Tizian, Arash Haghikia, Daniel Kirchhofer, Francois Mach, Lorenz Raeber, Christian M. Matter, W. H. Wilson Tang, Ulf Landmesser, Thomas F. Luescher, Ursula Rauch, Stanley L. Hazen
Summary: The study demonstrates that TMAO increases the risk of cardiovascular events and affects platelets and vascular tissue factor TF. Experimental results indicate that TMAO enhances arterial thrombosis potential by inducing the expression of TF and VCAM1.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kourosh Mohebian, Deike Hesse, Danny Arends, Gudrun A. Brockmann
Summary: The Bardet-Biedl Syndrome 7 (Bbs7) gene was identified as a potential candidate gene for juvenile obesity in BFMI mice. The expression of Bbs7 is significantly lower in the brain, adipose tissue, and liver of BFMI mice compared to B6N mice. DNA sequence comparison revealed several variants in the Bbs7 promoter region. A single-nucleotide polymorphism (SNP) was found to be associated with reduced reporter gene expression. This SNP is present in other mouse strains as well, but the Bbs7 transcript levels are not affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
David Romano, Lucia Garcia-Gutierrez, Nourhan Aboud, David J. Duffy, Keith T. Flaherty, Dennie T. Frederick, Walter Kolch, David Matallanas
Summary: This study reveals that the MST2 pathway plays a critical role in the development of resistance to BRAF inhibitors in malignant melanoma. The BRAFV600E mutant protein inhibits the proapoptotic signaling of the MST2 pathway by binding to MST2, reducing apoptosis induced by BRAF inhibitors. In BRAF inhibitor-resistant cell lines, MST2 pathway proteins are down-regulated through ubiquitination and subsequent proteasomal degradation, rendering cells resistant to MST2 pathway-induced apoptosis.
LIFE SCIENCE ALLIANCE
(2022)
Article
Medicine, Research & Experimental
Ming Fu, Ledong Tan, Zefeng Lin, Vincent C. H. Lui, Paul K. H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen
Summary: This study revealed that the reduction of STAT3, enhanced expression of IL-8 and CXCL1, and promotion of interferon-responsive neutrophil accumulation may lead to damage of biliary epithelial cells in BA patients.
Article
Biology
Yi-Fan Qi, Yang Yang, Yan Zhang, Shuzhen Liu, Bing Luo, Wen Liu
Summary: This study identified differentially expressed genes in NPC cells with down-regulated LTF and explored the potential molecular mechanism of how LTF enhances radiosensitivity through interaction with specific genes. Furthermore, the study predicted target genes of miR-214 to complement the mechanism associated with radiotherapy resistance, indicating the role of miR-214 as a negative regulator in regulating radiotherapy effect.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: Metastasis is a crucial factor in cancer-related deaths, and suppressing it can improve the survival rate of cancer patients. Nanoparticles with dual functionality have been developed to inhibit tumor metastasis and enhance the efficacy of loaded drugs against tumors. These versatile carriers show promise in treating invasive solid tumors and metastases by significantly reducing metastatic nodules.
Article
Oncology
Shanshan Hu, Paipai Guo, Zhen Wang, Zhengwei Zhou, Rui Wang, Mei Zhang, Juan Tao, Yu Tai, Weijie Zhou, Wei Wei, Qingtong Wang
Summary: IL-6-triggered Th17 cell expansion plays a crucial role in immune diseases like RA. The study reveals that the differentiation of Th17 cells induced by IL-6 involves not only JAKSTAT3-RORγt signaling but also GRK2-A(3)AR-cAMP-PKA-CREB/ICER-RORγt pathway, highlighting the significance of GRK2-controlled cAMP signaling in Th17 cell differentiation and its potential therapeutic application in Th17-driven immune diseases.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Urology & Nephrology
Aldhabi Mokhtar, Chuize Kong, Zhe Zhang, Yan Du
Summary: The study revealed that the overexpression of lncRNA-SNHG15 in bladder cancer tissues and cell lines was positively associated with tumor stage and size, while down-regulation of lncRNA-SNHG15 by siRNA significantly inhibited the proliferation and invasion capabilities of UMUC3 and T24 cells, suggesting a potential molecular target for future tumor targeted therapy.
Article
Toxicology
Xiaojiang Qin, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Angi Gao, Yuxuan Hao, Xuieng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li
Summary: This study aimed to investigate the role of connexin 43 (Cx43) in nicotine-induced pulmonary artery remodeling. It was found that the expression of Cx43 mRNA and protein in the pulmonary arteries decreased, while nicotine treatment significantly increased Cx43 expression and induced morphological changes in the pulmonary arteries. These findings suggest that Cx43 plays a crucial role in pulmonary artery reactivity and permeability in mice.
TOXICOLOGY LETTERS
(2023)
Article
Pathology
Aixiu Zhou, Qiongyi Cai, Yiting Hong, Yuchun Lv
Summary: This study found that the expressions of CK1 alpha and Atg7 were significantly decreased in endometriosis, while overexpression of CK1 alpha significantly increased the expressions of autophagy-related proteins. CK1 alpha regulates PTEN/Atg7-mediated autophagy in endometriosis.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Rheumatology
Iris K. Madera-Salcedo, Ada L. Ramirez-Sanchez, Noe Rodriguez-Rodriguez, Roberto Garcia-Quintero, Rosa M. Rubio, Gabriela Morales-Montes de Oca, Emmanuel Davalos, Rogelio Cuervo, Janette Furuzawa-Carballeda, Jorge Alcocer-Varela, Diana Gomez-Martin, Marysol Gonzalez-Yanez, Abigail de la Cruz, Adrian Albarran-Godinez, Gerardo Suarez-Rojas, Juanita Romero-Diaz, Norma O. Uribe-Uribe, Marta Alarcon-Riquelme, Mayra Furlan-Magaril, Juan Manuel Mejia-Vilet, Jose C. Crispin, Florencia Rosetti
Summary: This study investigated the association between variants in the STAT4 gene and systemic lupus erythematosus (SLE) and other autoimmune diseases. The results showed that carriers of the risk variant exhibit increased expression of STAT4 and enhanced proinflammatory capacities, which are associated with more severe disease in patients with SLE.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Environmental Sciences
Tzu-Chao Chuang, Kuohui Wu, Ying-Yu Lin, Han-Peng Kuo, Ming-Ching Kao, Vinchi Wang, Shih-Chung Hsu, Shou-Lun Lee
Summary: Berberine reduces the motility and invasiveness of ovarian cancer cells by depleting EGFR and ErbB2, and down-regulating their downstream targets through the EGFR-ErbB2/PI3K/Akt signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. Franklin, Nora Voormolen, Isabell K. Bones, Tijmen Korteweg, Martin N. J. M. Wasser, Henrike G. Dankers, Daniele Cohen, Marijn van Stralen, Clemens Bos, Matthias J. P. van Osch
Summary: The study investigates the technical feasibility of using VS-ASL for perfusion imaging in breast cancer patients and demonstrates its effectiveness in distinguishing mass lesions from nonmass lesions. The assessment results show that VS-ASL performs consistently well in terms of lesion visibility and artifact scores.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Elias Hurtado-Gaitan, Susana Selles-Marchart, James Hartwell, Maria Jose Martinez-Esteso, Roque Bru-Martinez
Summary: The study found that under CD induction conditions, PPCK was down-regulated, stilbene production increased, and PPC activity was lost in both cell cultures and leaves. Additionally, STS transcripts were co-induced with MYB14 and WRKY24 in both tissues. These genes had not been previously reported to respond to CD in grape leaves.
Review
Immunology
Syamal K. Datta
Summary: Autoantigen-directed tolerance can be induced by histone peptide epitopes in nanomolar dosage, leading to sustained remission of disease in SLE mice. Treatment with these peptide epitopes can also generate potent Treg cells in lupus patients, inhibiting autoimmune responses and reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
