Article
Chemistry, Multidisciplinary
Longwei Wang, Xiaodi Zhang, Zhen You, Zhongwei Yang, Mengyu Guo, Jiawei Guo, He Liu, Xiaoyu Zhang, Zhuo Wang, Aizhu Wang, Yawei Lv, Jian Zhang, Xin Yu, Jing Liu, Chunying Chen
Summary: The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. We explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that enables effective tumor ferroptosis with minimal side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Fuchun Nan, Qingyan Jia, Xiaokuang Xue, Shuai Wang, Weimin Liu, Jian Wang, Jiechao Ge, Pengfei Wang
Summary: This study presents a new type of high-performance nanozyme for multifunctional nanotheranostic use. The nanozyme, assembled with iron phthalocyanine and a polymer, shows multiple enzyme-like activities and can generate dual reactive oxygen species. It also demonstrates enhanced catalytic therapy under the influence of the tumor microenvironment and near-infrared light-responsive photothermal effect.
Article
Engineering, Environmental
Liying Zhang, Pei Xie, Hang Wu, Jiulong Zhao, Shige Wang
Summary: In this study, a two-dimensional MoSe2@PVP nanosheets were fabricated as an artificial enzyme to treat acute pancreatitis (AP) by eliminating reactive oxygen species (ROS) and reactive nitrogen species (RNS). The nanosheets showed good biocompatibility and demonstrated excellent ROS and RNS scavenging abilities. In vivo experiments on an animal model of AP confirmed the therapeutic effect of the nanosheets in reducing the levels of certain inflammatory factors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Yun Sun, Bolong Xu, Xueting Pan, Hongyu Wang, Qingyuan Wu, Shanshan Li, Bingyin Jiang, Huiyu Liu
Summary: Carbon-based nanomaterials with enzyme-like activity show great potential in biomedical applications. They have abundant active sites, excellent stability, and good biological safety. The unique optical, thermal, and acoustic properties of carbon-based nanozymes provide a multifunctional platform. This review discusses their recent research progress, challenges, and perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Yuan Gao, Shihong Liu, Xinchun Zeng, Zhixiong Guo, Da Chen, Sanzhong Li, Zhimin Tian, Yongquan Qu
Summary: Endothelial dysfunction induced by severe oxidative stress damage plays a critical role in the pathogenesis and progression of atherosclerosis. This study demonstrates that gadolinium-doped CeO2 nanozymes effectively scavenge reactive oxygen species (ROS) and show promising antiatherosclerosis performance. The Gd/CeO2 nanozymes reduce vascular lesions and lipid accumulation in macrophages, decrease inflammatory factor levels, and can serve as T1-weighted magnetic resonance imaging contrast agents for plaque localization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Wu Qingzhi, Sijia Zou, Qian Wang, Lei Chen, Xiyun Yan, Lizeng Gao
Summary: Nanozymes, as artificial enzyme mimics, show promise in inducing fungal death due to their tunable catalytic activity, high stability, and low cost. Natural enzymes play a crucial role in defending against fungi, while nanozymes offer potential in antifungal performance and applications, yet facing challenges in this field.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Engineering, Environmental
Pei Wang, Lianguo Wang, Yilan Zhan, Yifan Liu, Ziqiang Chen, Jia Xu, Jun Guo, Jun Luo, Junchao Wei, Fei Tong, Zhihua Li
Summary: Given the limitations of clinical curettage for periodontitis, improved medical therapy is needed for thorough removal of dental plaque and periodontal tissue repair. The development of local drug delivery systems (LDDSs) for adjuvant periodontitis therapy has faced challenges such as low anti-biofilm effect and tissue damage caused by excessive reactive oxygen species (ROS). In this study, versatile nanocomposites (PPM NPs) were fabricated using polydopamine-coated Prussian blue nanoparticles (PB NPs) loaded with minocycline (Mino), which showed enhanced antibacterial and anti-inflammatory effects for periodontitis treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li, Hao Chen, Lizeng Gao
Summary: This study synthesized mackinawite nanozymes (GFeSNs) from glutathione and iron ions, and found that GFeSNs have broad-spectrum antioxidant properties and can significantly improve the treatment outcomes of acute kidney injury (AKI) by scavenging reactive oxygen species (ROS).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Xinyue Guo, Zongjia Li, Sitong Liu, Miaomiao Zhang, Yanxue Guan, Juan Qin, Xiaomeng Li, Bailin Zhang, Jilin Tang
Summary: This study investigated the influence of PDA@CeO2 nanoparticles on cell ultra-morphology and mechanical properties, demonstrating their potential in protecting cells from oxidative stress damage. The findings provide new insights into the biological effects of nanomaterials through analyzing changes in cell microstructure and biomechanics.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nanoscience & Nanotechnology
Polina Ivanova, Konrad Dziegielewski, Marcin Drozd, Sandra Skorupska, Ilona Grabowska-Jadach, Mariusz Pietrzak
Summary: Reactive oxygen species (ROS) are important in physiological processes but can pose a threat to health with increased concentrations. Different defense systems in plants, invertebrates, and vertebrates including humans combat ROS, but environmental conditions and lifestyle can interfere with enzyme activity. Therefore, finding alternative ROS scavengers is crucial, with nanozymes being a proposed solution to mimic essential enzyme activities and prevent excessive ROS activity.
Article
Engineering, Environmental
Xiqing Cheng, Xirong Zhou, Zhiping Zheng, Qin Kuang
Summary: Transition metal-based metal-organic frameworks (MOFs) nanozymes have attracted extensive attention due to their unique porous structure and promising applications. However, the lack of understanding the catalytic mechanisms of MOF-based nanozymes makes it difficult to construct high-performance MOF-based nanozymes. This study developed a metal node engineering strategy to construct highly efficient 1D substrate transport and catalytic sub-nanochannels within Fe-based (MIL-53(Fe)) nanozymes, showing improved sensitivity and selectivity for the detection of H2O2 and glutathione.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Yang Zhu, Yaxin Liao, Jianhua Zou, Junjie Cheng, Yuanbo Pan, Lisen Lin, Xiaoyuan Chen
Summary: Nanomaterials with enzyme-mimicking properties, known as nanozymes, have become an alternative to natural enzymes due to their advantages, such as stability, ease of preparation, and catalytic performance. Single atom nanozymes (SAzymes) have recently been developed, showing superior catalytic performance and selectivity, and have made progress in biomedical applications. This review systematically summarizes the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications, and discusses their potential challenges and prospects for future development.
Article
Chemistry, Multidisciplinary
Yang Liu, Bo Wang, Junjie Zhu, Xinnan Xu, Bin Zhou, Yang Yang
Summary: Nanozyme catalytic therapy triggered by tumor-specific endogenous stimuli is limited by the catalytic efficiency and concentration of substrates. Researchers developed a novel and efficient Ir-N-5 single-atom nanozyme with multiple enzyme-like activities. The Ir-N-5 SA exhibited better catalytic performance and could generate reactive oxygen species and other reactions, realizing efficient nanozyme catalytic therapy in a substrate-cycle manner. The Ir-N-5 SA/Cer nanoagent disrupted redox and metabolic homeostasis in the tumor region, overcoming the limitations of current nanozyme catalytic therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Feng Wang, Qinghe Wu, Chunfu Zhang, Lingchi Kong, Rongtai Zuo, Kai Feng, Guoping Jia, Mengfei Hou, Jianhua Zou, Yimin Chai, Jia Xu, Xiaoyuan Chen, Qinglin Kang
Summary: The management of diabetic wounds is challenging due to bacterial infections and chronic inflammation. This study proposes a two-phase treatment strategy using reactive oxygen species (ROS) to combat infection and promote wound regeneration. The strategy effectively eliminates bacteria and stimulates wound healing.
Article
Engineering, Biomedical
Bao-Ping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tian-Wen Lai, Jingxiong Lu, Yun Zhao, Yang Du, Zeyu Liang, Chen Zhu, Wei Shao, Wen Li, Zhi-Hua Chen, Xiaolian Sun, Xiaoyuan Chen, Songmin Ying, Daishun Ling, Huahao Shen
Article
Chemistry, Multidisciplinary
Fangyuan Li, Zeyu Liang, Jianan Liu, Jihong Sun, Xi Hu, Meng Zhao, Jiaxin Liu, Ruiliang Bai, Dokyoon Kim, Xiaolian Sun, Taeghwan Hyeon, Daishun Ling
Correction
Engineering, Biomedical
Bao-ping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tian-wen Lai, Jingxiong Lu, Yun Zhao, Yang Du, Zeyu Liang, Chen Zhu, Wei Shao, Wen Li, Zhi-hua Chen, Xiaolian Sun, Xiaoyuan Chen, Songmin Ying, Daishun Ling, Huahao Shen
Article
Chemistry, Multidisciplinary
Xi Hu, Fangyuan Li, Fan Xia, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, Daishun Ling
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Engineering, Biomedical
Min Wei, Jiyoung Lee, Fan Xia, Peihua Lin, Xi Hu, Fangyuan Li, Daishun Ling
Summary: Nanozymes, as nanomaterials with enzyme-like properties, exhibit high catalytic stability and have low manufacturing and storage costs, attracting researchers from various fields. Chemically designed nanozymes with robust catalytic activity, tunable specificity, and multifunctionalities show promise in biomedical applications. It is important to understand the correlation between the physicochemical characteristics and catalytic activities of nanozymes.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Xi Hu, Fan Xia, Jiyoung Lee, Fangyuan Li, Xiaoyang Lu, Xiaozhen Zhuo, Guangjun Nie, Daishun Ling
Summary: Nanomaterials have potential applications in the diagnosis and treatment of PDAC, but a deeper understanding of nano-bio interactions in the microenvironment of PDAC is needed. Detecting potential biomarkers and understanding nano-bio interactions in the tumor microenvironment is crucial for designing effective nanomedicine tailored to PDAC.
Article
Engineering, Biomedical
Yixuan Guo, Yu Liu, Wei Wu, Daishun Ling, Qiao Zhang, Peng Zhao, Xi Hu
Summary: This article will discuss different types of IDO inhibitors and relevant clinical trials, especially feasible combined therapeutic modalities. In addition, it will also review cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities to effectively enhance the effectiveness of cancer therapy. Finally, the prospects of IDO inhibitors in clinical application and potential breakthroughs will be briefly discussed.
Review
Biochemistry & Molecular Biology
Xi Hu, Zhijie Jiang, Longyu Teng, Hongyu Yang, Dongsheng Hong, Dongsheng Zheng, Qingwei Zhao
Summary: Platinum drugs are widely used in cancer treatment, but platinum-induced peripheral neuropathy is a challenge. Reactive oxygen species generation is a key mechanism, which can be alleviated by antioxidant drugs. Nanotechnology is also utilized for preventing and treating PIPN.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Fan Xia, Xi Hu, Bo Zhang, Xun Wang, Yunan Guan, Peihua Lin, Zhiyuan Ma, Jianpeng Sheng, Daishun Ling, Fangyuan Li
Summary: This study introduces a size regulation strategy to enhance the antioxidant enzyme-like activities of RuNPs, showing promising potential for the treatment of oxidative stress-associated diseases.
Review
Immunology
Xi Hu, Chen Jia, Jianyong Wu, Jian Zhang, Zhijie Jiang, Kuifen Ma
Summary: This review discusses the clinical manifestations and current treatment options for Parvovirus B19 (B19V) infection. It highlights the lack of specific therapeutic methods for B19V and emphasizes the importance of identifying potential targets by understanding the virus's life cycle. The review also presents antiviral agents that block viral invasion and inhibit enzymes or regulatory proteins involved in DNA synthesis, and outlines the applications of nanotechnology in B19V treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Min Wei, Jiahe Wu, Heng Sun, Bo Zhang, Xi Hu, Qiyue Wang, Bowen Li, Lilan Xu, Teng Ma, Jianqing Gao, Fangyuan Li, Daishun Ling
Summary: The emergence and evolution of antimicrobial resistance (AMR) present a significant challenge for infection treatment. This study demonstrates the potential of enzyme-mimetic nanomaterials, specifically silver nanoclusters (Ag NCs), as adjuvants to modulate infectious microenvironments and potentiate antibiotics. The developed enzymatic nanoadjuvant (EnzNA) composed of Ag NCs can disassemble in the acidic biofilm microenvironment to exhibit biofilm-destructive oxidase-mimetic activity. Once internalized by bacteria, the Ag NCs switch to reveal thiol oxidase-mimetic activity, suppressing ribosomal biogenesis and inhibiting AMR reversal and evolution of pathogens. The EnzNAs show enhanced efficacy of existing antibiotics against methicillin-resistant Staphylococcus aureus and improve the treatment outcomes of biofilm-mediated skin infection and lethal lung infection in mice.
Article
Multidisciplinary Sciences
Fangyuan Li, Heng Sun, Jiafeng Ren, Bo Zhang, Xi Hu, Chunyan Fang, Jiyoung Lee, Hongzhou Gu, Daishun Ling
Summary: In this study, a nuclease-mimetic platinum nanozyme was developed to target cancer cell nuclei and induce concurrent DNA platination and oxidative cleavage, overcoming platinum drug resistance. Unlike conventional platinum nanoparticles, the platinum nanozyme specifically cleaves the formed platinum-DNA adducts by generating reactive oxygen species, disrupting the DNA bending required for nucleotide-excision repair. This approach allows for excessive accumulation of platinum-DNA adducts in cisplatin-resistant cancer cells, enabling highly efficient cancer therapy.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xia Guo, Hongwei Liao, Jiaming Tian, Chuang Yang, Fan Xia, Wenshi Liang, Nan Wang, Pin Li, Bo Zhang, Linji Gong, Xi Hu, Liang Zhang, Fangyuan Li, Daishun Ling
Summary: Bimetallic nanocatalyst efficiently generates singlet oxygen from ground-state oxygen through strain and electronic effects, demonstrating high catalytic performance and acidity-dependent antitumor effects both in vitro and in vivo.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Review
Materials Science, Biomaterials
Qiyue Wang, Shuying Wang, Xi Hu, Fangyuan Li, Daishun Ling
BIOMATERIALS SCIENCE
(2019)
