Article
Engineering, Chemical
Joynal Abedin, Shamim Mahbub, Mohammad Majibur Rahman, Anamul Hoque, Dileep Kumar, Javed Masood Khan, Ahmed M. El-Sherbeeny
Summary: The study investigated the interaction between BSA and TTAB in different solvents, finding changes in critical micelle concentration and spontaneity of micellization process. The addition of salt decreased the cmc value in mixed systems, while temperature and additives influenced the dissociation degree and fraction of ion binding. The free energy of micellization was found to be negative, indicating energetically spontaneous micellization process.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Physical
Hira Lal, Mohd Akram, Kabir-ud-Din
Summary: This study investigates the binding of a biodegradable gemini surfactant with the transport protein bovine serum albumin (BSA). The surface and interfacial properties of the surfactant were perturbed upon interaction with BSA. The results suggest that the surfactant binds strongly with BSA through static quenching, and hydrogen bonding and van der Waals forces play a major role in the interaction mechanism.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Run-Hui Ma, Wei Wang, Cai-Ping Hou, Yi-Fei Man, Zhi-Jing Ni, Kiran Thakur, Jian-Guo Zhang, Zhao-Jun Wei
Summary: It was found that bovine serum albumin (BSA) and glycosylated bovine serum albumin (GBSA) prepared in a nature deep eutectic solvent system show stronger interactions with kaempferol (Kae). GBSA-Kae nanoparticles (NPs) exhibited higher zeta-potential values, lower polydispersity index (PDI), higher encapsulation efficiency (EE), and loading capacity (LC) compared to BSA-Kae NPs. Structural characterization and stability analysis confirmed the stability of GBSA-Kae NPs. This study provides a theoretical foundation for improving the solubility and stability of Kae during its delivery and transport.
Article
Chemistry, Medicinal
Yifan Wang, Si Chen, Xin Yang, Shuang Zhang, Chunying Cui
Summary: Optimizing the preparation of BSA NPs, the study found that BSA NPs/siRNA showed stable efficacy both in vitro and in vivo, showing promise as an effective system for siRNA-based gene therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Raghu Solanki, Hadis Rostamabadi, Sunita Patel, Seid Mahdi Jafari
Summary: Bovine serum albumin nanoparticles (BSA NPs) are promising for efficient anti-cancer drug delivery due to their non-toxicity, non-immunogenicity, biodegradability, biocompatibility, and high drug-binding capacity. Understanding the structural/physicochemical features of BSA molecule and its derived nanovehicles, as well as effective variables in delivery mechanism, is essential for leveraging the potential of this carrier in cancer therapy. The review highlights recent advances in using BSA NPs for delivering anti-cancer agents and discusses the factors influencing the efficiency of therapeutics in nano-delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Abhishek Udnoor, Manjunath Lokolkar, Basappa C. Yallur, Raju Kale, Muttanagoud N. Kalasad, Umesha Katrahalli, Devagondanahalli H. Manjunatha
Summary: Inducing bio-functionalization in noble metal nanoparticles is crucial for their biocompatibility in biological activities. In this study, ZnO/Ag nanoparticles were synthesized and their interaction with bovine serum albumin was evaluated. The results showed that ZnO/Ag nanoparticles significantly reduced the intrinsic fluorescence intensity of bovine serum albumin and induced conformational modifications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Elham Ziaee, Behzad Shareghi, Sadegh Farhadian, Lida Momeni, Fatemeh Heibati-Goojani
Summary: Serum albumins are abundant plasma proteins that act as carriers for compounds like drugs. Polyamines like putrescine can interact with negatively charged molecules and affect the structure of bovine serum albumin. The formation of a complex between putrescine and bovine serum albumin alters its hydrophobicity and is found to have a spontaneous binding process.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Physical
Afreen Banu, Rizwan Hasan Khan, Mohssen T. A. Qashqoosh, Yahiya Kadaf Manea, Mohammad Furkan, Saeeda Naqvi
Summary: This study investigated the interaction mechanism of the drug Bisacodyl with carrier proteins including Bovine Serum Albumin, Human Serum Albumin, and Bovine Hemoglobin, revealing static quenching mechanism and complex formation. The findings showed conformational changes in the proteins' structures and higher quenching effect on Tryptophan residue compared to Tyrosine residue. The spectroscopic studies were supported by computational analysis, indicating the formation of complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Hui Zhang, Yanzhen Zhang, Yongqi Huang, Ling Wu, Qianwan Guo, Qi Wang, Li Liang, Katsuyoshi Nishinari, Meng Zhao
Summary: The study revealed the weak interaction between COS2-6 and BSA, primarily stabilized by electrostatic and hydrophobic forces, providing important insights into the potential of COS in food applications.
Article
Spectroscopy
Jie Bai, Xuekai Sun, Bing Geng, Xiping Ma
Summary: FTIR, fluorescence, and UV-vis absorption techniques were used to study the interaction between Cu+ and Cu2+ and bovine serum albumin (BSA) under simulated physiological conditions. The spectroscopic analysis showed that Cu+/Cu2+ could quench the intrinsic fluorescence emitted by BSA through static quenching with binding sites of 0.88 and 1.12 for Cu+ and Cu2+ respectively. The interaction was mainly driven by electrostatic force, as indicated by the negative ΔH and positive ΔS values. This study provides insight into the toxicological effects of different speciation of copper at the molecular level.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Correction
Chemistry, Multidisciplinary
Sonali S. Rohiwal, Z. Ellederova, Arpita P. Tiwari, Mohammed Alqarni, Sara T. Elazab, Gaber El-Saber Batiha, Shivaji H. Pawar, Nanasaheb D. Thorat
Summary: The study focuses on the self-assembly of BSA-dextran bio-nanoconjugate and its potential applications in antioxidant and wound healing. Experimental results indicate promising prospects for the use of this bio-nanoconjugate.
Article
Polymer Science
Sandra Aulia Mardikasari, Gabor Katona, Bence Sipos, Rita Ambrus, Ildiko Csoka
Summary: This study focuses on the optimization of bovine serum albumin (BSA) nanoparticles as a carrier system for nasal drug delivery. The ratio of BSA and ethanol is found to play a critical role in the nanoparticle characteristics of BSA nanogel matrices (BSA-NGs). The BSA-NGs exhibit moderate mucoadhesive properties and viscosity suitable for nasal liquid preparations. The in vitro release studies show high drug release within 4 hours. BSA nanoparticle gelling matrices have the potential to improve nasal drug administration.
Article
Chemistry, Physical
Elham Ziaee, Behzad Shareghi, Sadegh Farhadian
Summary: BSA, as a carrier protein, plays important roles in maintaining extracellular fluid volume stability and interacting with polyamines such as spermine. The binding of spermine to BSA alters its structure and significantly affects its fluorescence properties, indicating a stabilizing effect of spermine on BSA.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agriculture, Multidisciplinary
Jyoti Jaiswal, Amit Kumar Srivastav, Rahul Patel, Umesh Kumar
Summary: The encapsulation of fucoxanthin in rhamnolipid fabricated bovine serum albumin loaded nanoparticles successfully improved its solubility dependent bioavailability, leading to an increase in its bioavailability. This nano formulation, derived from FDA-approved components, could be utilized for encapsulating other vital nutraceutical molecules.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Materials Science, Multidisciplinary
Kuo-Jung Lee, Ming-Husan Lee, Yung-Hui Shih, Chao-Ping Wang, Hsun-Yu Lin, Sheng-Rui Jian
Summary: This study focuses on the fabrication of carbon nanotube buckypaper composite films using pumping filtration and spin coating methods. The addition of surface modifiers improves the hydrophilic properties of the buckypaper and enhances its bonding with aqueous bovine serum albumin (BSA). The contact angles of the modified specimens are smaller than the unmodified specimen, indicating the improved hydrophilicity of the modified samples.
Article
Chemistry, Physical
Sharmin Sultana, Malik Abdul Rub, Marzia Rahman, Shahed Rana, Mohammad Majibur Rahman, Md Anamul Hoque, Yousef G. Alghamdi, Abdullah M. Asiri
Summary: In this study, the aggregation behaviors of PVA and TTAB in alcohols/diols media were investigated using conductivity measurements. The physico-chemical parameters and thermodynamic properties were determined. The results showed that the CMC values varied in different solvents, indicating the significant influence of solvents on the micelle formation of TTAB + PVA mixture. It was also found that PVA molecules interacted exclusively with TTAB through hydrogen bonding, ion-dipole, and hydrophobic interactions.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Md. Anamul Hoque, Shamim Mahbub, Md. Tuhinur R. Joy, Malik Abdul Rub, Shahed Rana, Dileep Kumar, Yousef G. Alghamdi, Abdullah M. Asiri, Mohammed Abdullah Khan
Summary: The micellization behavior of CTAB and BSA mixture in different diols media was studied. The critical micelle concentration (cmc) values of the mixture decreased with increasing temperature and followed the order: cmc(1,5-PD)>cmc(1,2-PrD)>cmc(2,3-BD). The degree of micelle ionization (a) increased with carbon chain length and temperature. The thermodynamic parameters and the contribution of the solvent were also evaluated.
CHEMICAL ENGINEERING COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Mohammad Asad, Muhammad Nadeem Arshad, Abdullah M. Asiri, Mohammed T. N. Musthafa, Salman A. Khan, Mohd Rehan, Mohammad Oves
Summary: A series of novel N-methylspiropyrrolidine hybrids were synthesized using 1,3-dipolar cycloaddition reaction, and their structures, antibacterial activity, and mechanism of action were investigated.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Engineering, Chemical
Arnop Dutta, Md Tuhinur R. Joy, Sk. Md. Ali Ahsan, Mansour K. Gatasheh, Dileep Kumar, Malik Abdul Rub, Md. Anamul Hoque, Mohammad Majibur Rahman, Nasrul Hoda, D. M. Shafiqul Islam
Summary: The aggregation behavior of the mixture of cetyltrimethylammonium chloride (CTAC) and moxifloxacin hydrochloride (MFH) in aqueous and alcoholic media was studied. The critical micelle concentration (CMC) and counter ion binding (beta) of the CTAC + MFH mixture were evaluated. The CMC values were dependent on the composition of alcohols and temperature, increasing with temperature. The micellization of the CTAC + MFH mixed system was delayed in alcoholic media. The association of CTAC + MFH mixture exhibited hydrophobic, ion-dipole, and electrostatic interactions.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Md. Anamul Hoque, Mohammad Idrish Ali, Malik Abdul Rub, Marzia Rahman, Shahed Rana, Mohammad Majibur Rahman, Dileep Kumar, Naved Azum, Abdullah M. Asiri, Mohammed Abdullah Khan
Summary: In this study, the association behavior of bovine serum albumin (BSA) and cetyl-trimethylammonium bromide (CTAB) was investigated using the conductivity method. The association phenomenon was detected by changes in conductivity and various physico-chemical properties. The interaction between BSA and CTAB was influenced by temperature and hydration extent. The binding interactions were believed to involve H-bonding, ion-dipole, and hydrophobic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Md. Nazrul Islam, Malik Abdul Rub, Md. Rafikul Islam, Md. Abdul Goni, Shahed Rana, Dileep Kumar, Abdullah M. Asiri, Yousef G. Alghamdi, Md. Anamul Hoque, Shariff E. Kabir
Summary: This study investigated the potential interactions between the antibiotic ceftriaxone sodium (CTS) and the surfactant triton X-100 (TX-100) in the presence and absence of various sodium based electrolytes and hydrotropic salts. The results showed that the hydrophilic interaction was significant when sodium salicylate (NaSal) was used, but not significant when sodium benzoate (NaBenz) was used. Thermodynamic variables were calculated to evaluate the nature of the interactions, and the findings may have important implications for pharmaceutical formulations and understanding drug-surfactant interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Zita Farkas Agatic, Kosta Popovic, Dileep Kumar, Dusan Skoric, Mihalj Posa
Summary: This study investigates the formation of binary mixed micelles of sodium cholate (SC) - hexadecyltrimethylammonium bromide (HDTAB) and sodium cholate (SC) - dodecyltrimethylammonium bromide (DTAB) in an aqueous NaCl solution. The interactions and conformations of the surfactants are analyzed using 2D ROESY spectrum. The results show synergistic interactions and the dependence of molar excess Gibbs free energy on the mole fraction of the surfactant.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Mezbah Hossain, Shamim Mahbub, Malik Abdul Rub, Shahed Rana, Md. Anamul Hoque, Dileep Kumar, Yousef G. Alghamdi, Mohammed Abdullah Khan
Summary: The interaction between crown ether (B18C6) and levofloxacin hemihydrate (LH) molecule has been studied using UV spectrometry, revealing the formation of a stable complex with strong interaction. This study aims to investigate the potential role of B18C6 in drug delivery due to its amphiphilic nature.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
S. M. Rafiul Islam, Md. Rafikul Islam, Shamim Mahbub, Kamrul Hasan, Dileep Kumar, Javed Masood Khan, Anis Ahmad, Md. Anamul Hoque, D. M. Shafiqul Islam
Summary: The phase separation behavior of non-ionic surfactants-drug in aqueous hydrotropes has been studied. The cloud point is found to be dependent on the concentration of hydrotropes, and the positive standard Gibbs free energy values indicate the non-spontaneity of phase separation. The thermodynamic properties of transfer and enthalpy entropy compensation entities are calculated and explained.
Article
Polymer Science
Aftab Aslam Parwaz Khan, Mallikarjunagouda B. Patil, Laxmibai P. Rathod, Shivalila G. Vader, Pankaj Raizada, Pardeep Singh, Maha M. Alotaibi, Mohammad Omaish Ansari, Anish Khan, Naved Azum, Malik Abdul Rub, Muhammad Nadeem Arshad, Abdullah M. Asiri
Summary: The study assessed the potential of nanocomposite membranes (NCMs) made of sodium alginate and embedded with synthesized zeolitic imidazole framework-8 (ZIF-8) as fillers for separating gaseous mixtures generated by methane reforming. ZIF-8 crystals were synthesized through hydrothermal synthesis, with sizes ranging from 50 to 70 nm. NCMs with 15% filler loading (synthesized ZIF-8) outperformed neat polymer membranes in terms of H-2 permeability and selectivity, achieving a purity of up to 95%. However, NCMs did not perform better than neat polymer membranes in separating gas mixtures. The combination of ZIF-8 and sodium alginate as fillers is a new and worth investigating.
Article
Polymer Science
Esraa M. Bakhsh, Sher Bahadar Khan, Nujud Maslamani, Ekram Y. Danish, Kalsoom Akhtar, Abdullah M. Asiri
Summary: In this study, CMC/CuO-TiO2 beads were developed as a catalyst for the reduction of organic and inorganic contaminants. These beads demonstrated excellent catalytic activity and stability.
Article
Chemistry, Physical
Mohammad Asad, Muhammad Nadeem Arshad, Abdullah M. Asiri, Hadi M. Marwani, Khalid A. Alamry, Mohammad Mahboob Alam, Syed Nazreen, Ahmed A. Elhenawy, Mohammed M. Rahman
Summary: N-Acylated-2-pyrazolines (NA2Pyr) were synthesized using chalcone and hydrazine hydrate, and their structures were determined. A metal ion sensor for lead (Pb2+) was developed by combining a conducting coating binder (PEDOT:PSS) with a NA2Pyr modified electrode (NA2Pyr/GCE). The sensor exhibited high sensitivity and a wide linear dynamic range.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Dileep Kumar, Mihalj Posa
Summary: The anions of bile acids form linear hydrophobic congeneric groups (LCG) in the lnk - lnCMC plane and in the plane of enthalpy and entropy of bile salts micellization. The formation of LCG is not solely determined by hydrophobic effect and interaction, but also related to the energy and entropy changes of the hydrogen bonds. This finding provides insight into the thermodynamic behavior of bile acids.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Zunera Khalid, Syed Salman Shafqat, Hafiz Adnan Ahmad, Munawar Ali Munawar, Sadaf Mutahir, Safaa M. Elkholi, Syed Rizwan Shafqat, Rahila Huma, Abdullah Mohammed Asiri
Summary: Diabetes is a chronic metabolic disorder characterized by high blood sugar levels due to insulin deficiency or ineffective use. Alpha-glucosidase inhibitors are commonly used to control hyperglycemia, but can cause side effects. This study synthesized and tested a new series of compounds for their alpha-glucosidase inhibition potential. The compounds 14k and 14l showed strong inhibitory activity and in silico studies confirmed their interactions with the enzyme. This research provides potential candidates for the development of new antidiabetic drugs.
Article
Engineering, Environmental
Sk Mehebub Rahaman, Madhuparna Chakraborty, Sandip Kundu, Subhendu Dhibar, Dileep Kumar, Samia M. Ibrahim, Manab Chakravarty, Bidyut Saha
Summary: In this study, SmF3 nanoparticles with a hexagonal closed pack structure were synthesized using W/O microemulsions. The crystal structure, composition, purity, and morphology of the nanoparticles were assessed using various techniques. The particle size distribution of the SmF3 nanoparticles was found to be dependent on the water to surfactant mole ratio (W0), with higher W0 resulting in larger particle size distribution. The nanoparticles showed the ability to adsorb phosphate ions from aqueous solution, with smaller nanoparticles exhibiting higher adsorption effectiveness due to their larger surface area.
JOURNAL OF HAZARDOUS MATERIALS ADVANCES
(2023)