Journal
JOURNAL OF PARKINSONS DISEASE
Volume 12, Issue -, Pages S65-S74Publisher
IOS PRESS
DOI: 10.3233/JPD-223152
Keywords
Parkinson's disease; T cells; CD4+T cells; CD8+T cells; neuroinflammation; peripheral immunity
Categories
Funding
- Fondazione CARIPLO [2011-0504]
- AGING PROJECTDepartment of Excellence-Universit`a del Piemonte Orientale
Ask authors/readers for more resources
This review discusses the involvement of T cells in Parkinson's disease, highlighting their roles in both the central and peripheral nervous system, their significance as biomarkers of disease progression, and recent therapeutic strategies targeting T cell response.
T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available