Article
Endocrinology & Metabolism
Esmeralda Hidalgo-Lopez, Isabel Noachtar, Belinda Pletzer
Summary: This study investigated the influence of anti-androgenic and progestin on the resting state functional connectivity (rs-FC) between the anterior cingulate cortex (ACC) and amygdala, while controlling for the androgenicity of progestin. The results showed that regardless of the androgenicity of progestin, rs-FC between the amygdala and frontal areas, as well as between ACC and temporoparietal areas, decreased with longer duration of HC use. However, the type of progestin had different effects on the gray matter volume of the left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Kathleen V. Casto, Timothy Jordan, Nicole Petersen
Summary: Oral contraceptives (OCs) are widely used and their potential effects on brain structure and function are being studied. Current research suggests that OCs may induce a hyperprogestogenic state in the brain.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Byung-Hoon Kim, Min-Kyeong Kim, Hye-Jeong Jo, Jae-Jin Kim
Summary: Social anxiety is prevalent among young adults, and machine learning models using brain functional radiomic features can successfully predict its level.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Sebastian Walther, Stephanie Lefebvre, Frauke Conring, Nicole Gangl, Niluja Nadesalingam, Danai Alexaki, Florian Wuthrich, Maximilian Ruter, Petra V. Viher, Andrea Federspiel, Roland Wiest, Katharina Stegmayer
Summary: The study examined the relationship between paranoia in schizophrenia patients and limbic circuitry, finding increased connectivity within the limbic circuit in patients with paranoia and with increasing severity of paranoia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Annchen R. Knodt, Michael R. Irwin, Camelia E. Hostinar
Summary: This study examined the association between peripheral inflammation and amygdala activity and connectivity in adolescents. The results showed that peripheral inflammation was associated with increased amygdala activity to emotional face stimuli and reduced connectivity with occipital and parietal regions. These findings enhance our understanding of the relationship between peripheral inflammation and neural response to emotional faces in adolescents.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Lucas E. Sainburg, Andrew P. Janson, Graham W. Johnson, Jasmine W. Jiang, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: Epilepsy surgery involves the resection of the epileptic focus and is used to treat drug-resistant focal epilepsy. However, focal brain lesions can have effects in distant brain regions. This study investigates the effects of focal disconnections in the brain network on function in distant brain regions using epilepsy surgery.
Article
Neurosciences
Lucas E. Sainburg, Aubrey A. Little, Graham W. Johnson, Andrew P. Janson, Kaela K. Levine, Hernan F. J. Gonzalez, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: This study investigates the fMRI signal alterations in patients with mesial temporal lobe epilepsy (mTLE) and provides insights into the relationship between these alterations and the severity of the disease. It also reveals the potential spread of epileptic fMRI activity across networks and the distinct properties of fMRI activity in the default mode network of mTLE patients.
Article
Neurosciences
Quan Gan, Ning Ding, Guoli Bi, Ruixiang Liu, Xingrong Zhao, Jingmei Zhong, Shaoyuan Wu, Yong Zeng, Liqian Cui, Kunhua Wu, Yunfa Fu, Zhuangfei Chen
Summary: Mindfulness and its interventions are commonly used as complementary treatments for psychological issues. This study explores the effects of mindfulness training on brain regions related to attention and interoceptive function in novices, showing intrinsic functional changes along with improved mindful abilities.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Adrian Andrzej Chrobak, Bartosz Bohaterewicz, Anna Maria Sobczak, Magdalena Marszal-Wisniewska, Anna Tereszko, Anna Krupa, Anna Ceglarek, Magdalena Fafrowicz, Amira Bryll, Tadeusz Marek, Dominika Dudek, Marcin Siwek
Summary: This study compared the baseline brain activity in euthymic bipolar disorder patients with healthy controls using various rs-fMRI analyses. Significant differences in ALFF, f/ALFF, slow-5, and ReHo were found between the two groups, suggesting distinct patterns of brain activity in BD patients compared to HC. The combination of different rs-fMRI methods may provide a more comprehensive understanding of the complex resting state abnormalities in bipolar disorder.
Article
Clinical Neurology
Xuejun Jiang, Feng Wu, Yifan Zhang, Huizi Li, Jiahui Kang, Lingtao Kong, Fei Wang, Yanqing Tang
Summary: This study investigated the association between brain function and gender in bipolar disorder using amplitude of low-frequency fluctuations (ALFF). The results indicated gender differences in dysfunction of the cortico-limbic neural system in BD. Male and female patients with BD showed different patterns of ALFF in various brain regions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Xiao Li, Jiamei Guo, Xiaolu Chen, Renqiang Yu, Wanjun Chen, Anhai Zheng, Yanjie Yu, Dongdong Zhou, Linqi Dai, Li Kuang
Summary: The efficacy of electroconvulsive therapy (ECT) in the treatment of adolescents with treatment-refractory depression is unsatisfactory, and it is unclear which factors are related to the treatment effect. Resting-state fMRI may be a good tool to predict the clinical efficacy of this treatment and identify the most suitable population for it.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Olivia K. Harrison, Xavier Guell, Miriam C. Klein-Flugge, Robert L. Barry
Summary: Mapping the connectivity of the central nervous system has been a key focus in neuroimaging research, with a recent shift towards exploring subcortical structures beyond traditional cortical investigations. Advances in neuroimaging technology now allow for better signal and resolution for studying these structures, although challenges and limitations still exist. Recommendations and considerations have been put forward for mapping brain connectivity beyond the cortex.
Article
Psychology, Biological
Jie Chen, Mengqi Zhao, Lina Huang, Yuansheng Liu, Xueying Li, Xize Jia, Qingguo Ding, Chunjie Wang, Pei Liang
Summary: By collecting resting-state functional magnetic resonance imaging (rs-fMRI) data from 22 participants, we found that sweet, sour, and tasteless gustatory stimulation had different effects on the functional activity in brain regions, including somatosensory areas, reward processing areas, and high-order cognitive functioning areas. These findings contribute to a further understanding of the neural network and mechanisms after taste exposure.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Liangsuo Ma, John M. Hettema, Janna Cousijn, James M. Bjork, Joel L. Steinberg, Lori Keyser-Marcus, Kyle Woisard, QiQi Lu, Roxann Roberson-Nay, Antonio Abbate, F. Gerard Moeller
Summary: The study found associations between the neural connections of cannabis users and anxiety/depression symptoms, potentially involving effective connections between multiple brain regions. Connections from the right amygdala to the left amygdala and from the anterior cingulate cortex to the left amygdala may be closely related to cannabis use and anxiety/depression symptoms, while connections from the medial prefrontal cortex to the right insula and from the left insula to the left amygdala may reflect a compensatory mechanism.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Federica Riva, Melanie Lenger, Martin Kronbichler, Claus Lamm, Giorgia Silani
Summary: Emotional egocentric bias is more prominent in children, adolescents, and older adults compared to young adults. The connectivity between the right supramarginal gyrus and somatosensory cortices acts as a partial mediator between age and emotional egocentric bias.
NEUROBIOLOGY OF AGING
(2022)
Article
Anesthesiology
Laila K. Franke, Stephan F. Miedl, Sarah K. Danboeck, Markus Grill, Michael Liedlgruber, Martin Kronbichler, Herta Flor, Frank H. Wilhelm
Summary: Psychological trauma is often accompanied by physical pain, with PTSD frequently co-occurring with chronic pain. Classical conditioning may explain the mechanism behind pain intrusions, where pain experiences can occur even without nociceptive input.
Article
Clinical Neurology
Lucas Johannes Rainer, Martin Kronbichler, Giorgi Kuchukhidze, Eugen Trinka, Patrick Benjamin Langthaler, Lisa Kronbichler, Sarah Said-Yuerekli, Margarita Kirschner, Georg Zimmermann, Julia Hofler, Elisabeth Schmid, Mario Braun
Summary: According to Panksepp's hierarchical emotion model, emotion processing relies on different brain regions. This study validates and extends this model in patients with JME. The results show that discrete emotions and affective dimensions are processed differently in different brain regions, and they are not affected by psychiatric conditions, seizure types, or duration of epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Isabel Noachtar, Ti-Anni Harris, Esmeralda Hidalgo-Lopez, Belinda Pletzer
Summary: This study investigated the sex differences in brain activation during different navigation strategies. The findings suggest that men rely more on spatial networks while women rely more on verbal networks.
COMMUNICATIONS BIOLOGY
(2022)
Letter
Anesthesiology
Laila K. Franke, Stephan F. Miedl, Sarah K. Danboeck, Michael Liedlgruber, Markus Grill, Martin Kronbichler, Herta Flor, Frank H. Wilhelm
Article
Nutrition & Dietetics
Anja Lender, Janina Wirtz, Martin Kronbichler, Sercan Kahveci, Simone Kuehn, Jens Blechert
Summary: This study investigated the behavioral and neural correlates of approach behavior toward chocolate using fMRI and reaction times. The results showed an approach bias toward chocolate, which was associated with activity in the medial OFC. This study highlights the importance of stimulus-specific cognitive trainings for healthy consumption and self-regulation.
Editorial Material
Neurosciences
Nicole Petersen, Adriene M. Beltz, Kathleen V. Casto, Caitlin M. Taylor, Emily G. Jacobs, Inger Sundstroem-Poromaa, Belinda Pletzer
Summary: The neuroscience of hormonal contraceptives is a crucial yet emerging field. Although limited in size and scope, existing studies emphasize the complex effects of hormonal contraceptives on the nervous system, which can vary due to individual differences, contraceptive type and formulation, and timing of use. Neuroscientists can provide individuals with knowledge about the biopsychological effects of hormonal contraceptives through rigorous randomized controlled trials, large-scale studies examining population-level trends, and dense imaging or intensive longitudinal studies assessing individual-level effects.
NATURE NEUROSCIENCE
(2023)
Article
Psychiatry
Esmeralda Hidalgo-Lopez, Jonas Engman, Inger Sundstrom Poromaa, Malin Gingnell, Belinda Pletzer
Summary: This study investigated the effects of hormonal contraceptives on mood side effects and found that they caused increased connectivity within the default mode network and decreased connectivity within the executive control network. Mood lability was the most consistent and prominent side effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Laura Schnetzer, Verena S. Schaetzle, Lisa Kronbichler, Juergen Bergmann, Stefan Leis, Alexander B. Kunz, Julia S. Crone, Eugen Trinka, Martin Kronbichler
Summary: Diagnosing patients with disorders of consciousness can be prone to misdiagnosis. This study aims to determine the proportion of patients who display covert command following and evaluate the prognostic value of improved diagnosis. The researchers used functional MRI and a motor imagery task to identify patients with cognitive motor dissociation. The results showed that some patients exhibited covert command following, while others showed increased brain activation during rest. Additionally, 40% of patients showed significant activations in the whole brain analysis.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Meeting Abstract
Clinical Neurology
L. J. Rainer, G. Kuchukhidze, E. Trinka, M. Braun, M. Kronbichler, P. Langthaler, G. Zimmermann, S. Said-Yurekli, M. Kirschner, L. Zamarian, H. Jokeit, J. Hofler
Meeting Abstract
Neurosciences
Lavinia Uscatescu, Christopher Hyatt, Martin Kronbichler, Vince Calhoun, Silvia Corbera, Kevin Pelphrey, Brian Pittman, Godfrey Pearlson, Michal Assaf
BIOLOGICAL PSYCHIATRY
(2022)