Article
Neurosciences
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko
Summary: This study investigated the inhibitory effects of GABAA receptors on different types of interneurons in mouse brain slices. The results showed that different types of interneurons have varying sensitivity to inhibition, and GABAA inhibition can decrease the excitability of one type of interneuron while not affecting another type.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Jing Zou, Samuel Andrew Hires
Summary: Recent research shows that inhibitory neurons expressing vasoactive intestinal polypeptide are specifically activated when rewards are anticipated, rather than when they are consumed.
Article
Biology
Christina Georgiou, Vassilis Kehayas, Kok Sin Lee, Federico Brandalise, Daniela A. Sahlender, Jerome Blanc, Graham Knott, Anthony Holtmaat
Summary: This study identifies a subset of superficial multipolar inhibitory interneurons expressing VIP with high dynamics, located in layer 1 of the cortex, and exhibiting the electrophysiological characteristics of bursting cells. The structural plasticity of these neurons is distinct from that of excitatory neurons.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Shao-Na Jiang, Jun-Wei Cao, Lin-Yun Liu, Ying Zhou, Guang-Yao Shan, Ying-Hui Fu, Yun-Chao Shao, Yong-Chun Yu
Summary: In this study, the morpho-electric properties and mRNA profiles of VIP+ interneurons in the mouse somatosensory cortex were comprehensively classified, and 3 electrophysiological types and 2 morphological types were identified. Through joint clustering, 3 morpho-electric types were determined, and distinct marker genes were found to be expressed in each type. This study establishes a basis for future investigations aiming to elucidate the physiological roles of VIP+ interneurons.
Article
Biochemistry & Molecular Biology
G. Dobrzanski, A. Lukomska, R. Zakrzewska, A. Posluszny, D. Kanigowski, J. Urban-Ciecko, M. Liguz-Lecznar, M. Kossut
Summary: In this study, the role of cortical SOM-INs and VIP-INs in a Pavlovian conditioning were examined, revealing the crucial involvement of L4 SOM-INs activity in learning-induced plastic changes. It is suggested that L4 SOM-INs may provide disinhibition by blocking L4 parvalbumin interneurons, allowing information flow into upper cortical layers during learning.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kuldeep Makwana, Harshita Chodavarapu, Nancy Morones, Jingyi Chi, William Barr, Edward Novinbakht, Yidan Wang, Peter Tuan Nguyen, Predrag Jovanovic, Paul Cohen, Celine E. Riera
Summary: The study revealed that genetic ablation of heat-sensing CGRPa neurons promotes resistance to weight gain upon high-fat diet feeding and increases energy expenditure in mice by reducing lipid deposition, enhancing fatty acid oxidation gene expression, and increasing lipolysis in adipocytes, as well as enhancing mitochondrial respiration in iBAT.
MOLECULAR METABOLISM
(2021)
Article
Neurosciences
Yingping Ma, Shaofei Jiang, Xin Zhao, Shen Li, Liping Chen, Zhe Zhao, Wei Shen, Yan Wu, Haitao Wu
Summary: In this study, the role of the anterior insular cortex (aIC) in visuospatial attention and impulsiveness in mice was assessed using the 5-choice serial reaction time task (5-CSRTT) testing paradigm. The results showed activation of c-Fos in aIC CaMKIIa neurons after the 5-CSRTT procedure, and enhanced calcium signaling in these neurons when the mice responded correctly. Suppression of aIC CaMKIIa neurons led to increased incorrect responses, while pharmacological activation enhanced performance in the 5-CSRTT test.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Multidisciplinary Sciences
Yan-Fen Chen, Qi Song, Paola Colucci, Federica Maltese, Cristina Siller-Perez, Karina Prins, James L. McGaugh, Erno J. Hermans, Patrizia Campolongo, Nael Nadif Kasri, Benno Roozendaal
Summary: Noradrenergic activation of the basolateral amygdala influences recognition memory by suppressing activity in the anterior insular cortex. This finding sheds light on the broader dynamics of the brain network involved in emotional regulation of memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Stewart S. Cox, Angela M. Kearns, Samuel K. Woods, Brogan J. Brown, Samantha J. Brown, Carmela M. Reichel
Summary: This study inhibits the anterior insula (AI) using pharmacological and chemogenetic methods and found that it plays a crucial role in targeted helping. Analysis of ultrasonic vocalizations revealed that distress calls from the targets increased when observers' helping was attenuated due to insula inhibition. It suggests that emotional transfer between observers and targets is weakened following observer AI inhibition. The study helps establish the anterior insula as a critical node in the empathic brain during targeted helping.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Zoltan Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ocsai, Dinu F. Albeanu, Balazs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs, Balazs Rozsa
Summary: This study identified a type of inhibitory neuron that is recruited by rewards and punishments and is activated throughout the cortex. The global response mode of these neurons may support a specific circuit mechanism that regulates reward and punishment information in local processing and plasticity.
Article
Biology
Colin M. Cleary, Brenda M. Milla, Fu-Shan Kuo, Shaun James, William F. Flynn, Paul Robson, Daniel K. Mulkey
Summary: The study reveals a limited diversity of inhibitory neurons in the parafacial region around RTN, with Sst+ neurons seemingly uniquely inhibited by CO2/H+. These neurons play an important role in the respiratory activity of RTN.
Article
Biochemistry & Molecular Biology
Jinyun Wu, Zhirong Zhao, Yun Shi, Miao He
Summary: Different classes of interneurons in the cortex exhibit distinct laminar distribution patterns, contributing to the organization of cortical microcircuits. This study focused on VIP+ interneurons and uncovered significant laminar differences in their transcriptomic profiles. Upper layer and deeper layer VIP+ interneurons were found to be transcriptionally distinct, with differential expression of genes involved in synapse organization and regulation of membrane potential. The findings also identified potential marker genes for upper layer VIP+ interneurons in different cortical regions, including Tac2 and CxCl14.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Saishree Badrinarayanan, Frederic Manseau, Sylvain Williams, Mark P. Brandon
Summary: The study reveals varying gradients in electrophysiological and morphological properties of VIP cells in the medial entorhinal cortex (MEC), with differences across layers and along the dorsal-ventral MEC axis. These results characterize the cellular and morphological properties of VIP cells in the MEC.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Multidisciplinary Sciences
Kyohei Kin, Jose Francis-Oliveira, Shin-ichi Kano, Minae Niwa
Summary: The study reveals that adolescent stress causes abnormal postpartum social behavior through the anterior insula-prelimbic cortex pathway and glucocorticoid receptor signaling. This finding provides important insights into understanding the mechanisms underlying the impact of adolescent stress on postpartum social behavior.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Katie A. Ferguson, Jenna Salameh, Christopher Alba, Hannah Selwyn, Clayton Barnes, Sweyta Lohani, Jessica A. Cardin
Summary: Cortical circuit function is regulated by VIP-INs, which play important roles in shaping circuit operation and modulating sensory processing according to the behavioral context.
Article
Neurosciences
Sara Ferrazzo, Ozge Gunduz-Cinar, Nadia Stefanova, Gabrielle A. Pollack, Andrew Holmes, Claudia Schmuckermair, Francesco Ferraguti
NEUROBIOLOGY OF DISEASE
(2019)
Article
Neurosciences
Massimo Trusel, Alvaro Nuno-Perez, Salvatore Lecca, Harumi Harada, Arnaud L. Lalive, Mauro Congiu, Kiwamu Takemoto, Takuya Takahashi, Francesco Ferraguti, Manuel Mameli
Article
Neurosciences
Arnau Ramos-Prats, Julia Koelldorfer, Elena Paolo, Maximilian Zeidler, Gabriele Schmid, Francesco Ferraguti
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Miodrag Mitric, Anna Seewald, Giorgia Moschetti, Paola Sacerdote, Francesco Ferraguti, Kai K. Kummer, Michaela Kress
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Sabine Krabbe, Enrica Paradiso, Simon D'Aquin, Yael Bitterman, Julien Courtin, Chun Xu, Keisuke Yonehara, Milica Markovic, Christian Mueller, Tobias Eichlisberger, Jan Grundemann, Francesco Ferraguti, Andreas Luthi
NATURE NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Lucille Alonso, Polina Peeva, Arnau Ramos-Prats, Natalia Alenina, York Winter, Marion Rivalan
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Luca Zangrandi, Claudia Schmuckermair, Hussein Ghareh, Federico Castaldi, Regine Heilbronn, Gerald Zernig, Francesco Ferraguti, Arnau Ramos-Prats
Summary: The study found that mGluR5(D1) cKO mice exhibited different coping mechanisms in response to escapable and inescapable stress, highlighting the functional integration of the dopaminergic and glutamatergic systems in controlling internal states upon stress exposure. The study directly implicates D1 neurons and mGluR5 as crucial mediators of behavioral stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Ayla Aksoy-Aksel, Andrea Gall, Anna Seewald, Francesco Ferraguti, Ingrid Ehrlich
Summary: Dopaminergic signaling is crucial for associative learning, particularly in fear and extinction learning. Intercalated cell (ITC) clusters within the amygdala receive dense dopaminergic projections, with novel mechanisms by which dopamine controls ITCs discovered in mice. These findings shed light on the dopaminergic mechanisms that regulate the balance between different ITC clusters, impacting fear behavior.
Article
Neurosciences
Astrid Rollenhagen, Max Anstoetz, Kerstin Zimmermann, Yu Kasugai, Kurt Saetzler, Elek Molnar, Francesco Ferraguti, Joachim H. R. Luebke
Summary: AMPA and NMDA glutamate receptors play essential roles in synaptic transmission and plasticity in the neocortex. The study reveals their layer- and target-specific distribution patterns in the adult rat neocortex, which contribute to the observed functional differences in synaptic transmission and plasticity.
Article
Cell Biology
Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gomez-Santacana, Amadeu Llebaria, Francesco Ferraguti
Summary: This study aimed to assess the impact of mGlu(5) inactivation on neuronal oscillatory activity during fear retrieval in cued fear conditioned mice, showing that inhibition of mGlu(5) signaling decreased freezing behavior during fear retrieval and reduced theta rhythmic activity in both the mPFC and vHPC.
Biographical-Item
Neurosciences
Francesco Ferraguti, Felipe Fredes, Wen-Hsien Hou, Peter Somogyi, Scott Thompson
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Sadegh Rahimi, Pariya Salami, Pawel Matulewicz, Armin Schmuck, Anneliese Bukovac, Arnau Ramos-Prats, Ramon Osman Tasan, Meinrad Drexel
Summary: This study assessed the role of VIP-INs in the pathophysiology of temporal lobe epilepsy and found that inhibiting VIP-INs in the ventral subiculum can reduce seizures. Additionally, transient activation of VIP-INs increases seizure frequency. These results highlight the crucial involvement of VIP-INs in modulating epilepsy.
EXPERIMENTAL NEUROLOGY
(2023)
