A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching

The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations = 45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies.

Automated summary

This study reveals the evolutionary history of S. japonicum by constructing its genome and analyzing samples from different populations. The research identifies a severe population bottleneck and several genomic regions under natural selection, providing insights into the adaptation of this parasite. The findings also highlight the association of certain genes with parasite development and infection, shedding light on potential targets for further studies.