Review
Chemistry, Multidisciplinary
Jingyang Zhang, Sofiya-Roksolana Got, Iris Xiaoxue Yin, Edward Chin-Man Lo, Chun-Hung Chu
Summary: Research has shown that silver diamine fluoride (SDF) is effective in preventing and arresting dental caries due to its mineralizing and antibacterial properties. Although several laboratory studies have demonstrated that SDF can prevent bacterial adhesion to the tooth surface, there are also clinical studies that have failed to show significant changes in microbial diversity on tooth plaque after SDF treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kalpana Bansal, Azeema Shamoo, Kalaivani Mani, K. Pavithra Devi, Ankita Verma, Vijay P. Mathur, Nitesh Tewari
Summary: This study compared the success rates of silver diamine fluoride-modified atraumatic restorative technique (SMART) and the conventional drill and fill method in restoring carious lesions in primary molars. The results showed no significant difference in the success rates of the two methods at 24 months, but children were more accepting of the SMART method. Therefore, SMART can be considered as an alternative option for treating asymptomatic carious lesions in primary molars, especially in uncooperative children.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Abla Ahmed Mohamed Aly, Amr Mahmoud Abdel Aziz, Reham Khaled Elghazawy, Reham Khaled Abou El Fadl
Summary: This study evaluated and compared the clinical performance and cost effectiveness of two different treatment methods (SMART and ART) in primary molars over a 12-month follow-up period. The results showed that although both techniques had comparable clinical performance and survival rates, SMART had a shorter treatment time and lower cost, making it a more advantageous option for treating children, patients with behavioral and medical challenges, and improving access to oral care among the underprivileged.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Iliana Gehui Yan, Faith Miaomiao Zheng, Sherry Shiqian Gao, Duangporn Duangthip, Edward Chin Man Lo, Chun Hung Chu
Summary: This study determined the concentrations of free fluoride and silver ions as well as the alkalinity of four commercially available 38% silver diamine fluoride (SDF) solutions. The results showed differences between the claimed and measured concentrations of fluoride and silver ions in these SDF products, which were found to be alkaline.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Iliana Gehui Yan, Faith Miaomiao Zheng, Iris Xiaoxue Yin, Ivy Guofang Sun, Edward Chin Man Lo, Chun Hung Chu
Summary: This study aims to determine the stability, alkalinity, and fluoride and silver ion concentrations of 5 commercially available 38% silver diamine fluoride (SDF) solutions. The study found that the alkalinity of the SDF solutions remained stable after 180 days, but the fluoride and silver concentrations decreased substantially after 60 days. It is recommended to use the SDF solution within 60 days after opening.
INTERNATIONAL DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elif Ballikaya, Gizem Erbas Unverdi, Zafer C. Cehreli
Summary: Both SDF and SMART sealants showed favorable short-term prevention against dental caries and effective desensitization in hypomineralized molars. The most common side effect of SMART sealants was marginal discoloration due to SDF application.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biology
Eman Alsagob, Nozha Sawan, Shahad Aladhyan, Nouf Alsalem, Abeer Alshami, Sarah Albluwi
Summary: This study found that delaying restoration by two weeks after applying SDF significantly reduced discoloration of caries-infected teeth samples under laboratory conditions, with neither composite nor GIC being superior.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Infectious Diseases
Amjad Almuqrin, Inder Preet Kaur, Laurence J. Walsh, Chaminda Jayampath Seneviratne, Sobia Zafar
Summary: Topical cariostatic agents, such as silver diamine fluoride (SDF), are effective in managing dental caries in young children. However, SDF application often leads to unaesthetic tooth discoloration, which can be addressed by using nano-metallic antimicrobials like selenium nanoparticles (SeNPs). SeNPs have shown antimicrobial, antioxidant, and antiviral activities, making them a potential substitute for silver in SDF.
Review
Dentistry, Oral Surgery & Medicine
Faith Miaomiao Zheng, Iliana Gehui Yan, Duangporn Duangthip, Sherry Shiqian Gao, Edward Chin Man Lo, Chun Hung Chu
Summary: Silver diamine fluoride (SDF) is an effective and safe treatment for early childhood caries, root caries, fissure caries, dentin hypersensitivity, hypomineralized teeth, dental erosion, and infected root canals. It has antimicrobial and remineralization-promoting properties, and is simple, painless, and cost-effective, making it widely accepted.
JAPANESE DENTAL SCIENCE REVIEW
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chloe Meng Jiang, Duangporn Duangthip, Alice Kit Ying Chan, Manisha Tamrakar, Edward Chin Man Lo, Chun Hung Chu
Summary: Global research interest in silver diamine fluoride (SDF) in dentistry has increased significantly in recent years, mainly focused on dental caries. The three main types of research are laboratory/animal studies, review/guidelines, and clinical trials, with the citation count being significantly different among them. The popularity of SDF as indicated by Google Trends has also seen a significant increase.
JOURNAL OF DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chloe Meng Jiang, May Chun Mei Wong, Chun Hung Chu, Linlu Dai, Edward Chin Man Lo
Summary: This study investigated the short-term and long-term changes in parental satisfaction and oral health-related quality of life (OHRQoL) of preschool children after receiving atraumatic restorative treatment (ART) with or without prior silver diamine fluoride (SDF) application. The results showed that regardless of prior SDF application, both the short-term and long-term parental satisfaction with their child's dental health status improved after one-off placement of ART restorations. However, there were no significant changes in the children's OHRQoL.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alice Kit Ying Chan, Yiu Cheung Tsang, Chloe Meng Jiang, Katherine Chiu Man Leung, Edward Chin Man Lo, Chun Hung Chu
Summary: This study aimed to evaluate the desensitizing effect of 38% silver diamine fluoride (SDF) solution on hypersensitive teeth in older adults. A double-blind randomized clinical trial was conducted, and participants received either 38% SDF or 5% potassium nitrate solution (control) on the root surface. The results showed that 38% SDF solution reduced hypersensitivity on the exposed root surface of older adults and was more effective than the control solution.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ahmed Zaeneldin, Ollie Y. Yu, Chun-Hung Chu
Summary: This study systematically reviewed the dental pulp response to silver diamine fluoride (SDF) treatment and found that direct SDF application caused pulp necrosis, while indirect application was generally biocompatible with mild inflammatory response, increased odontoblastic activity, and increased tertiary dentine formation in dental pulp.
JOURNAL OF DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Beatriz Martines de Souza, Mayara Souza Silva, Aline Silva Braga, Patricia Sanches Kerges Bueno, Paulo Sergio da Silva Santos, Marilia Afonso Rabelo Buzalaf, Ana Carolina Magalhaes
Summary: The study found that TiF4 and SDF can effectively reduce radiation-induced dentin caries by decreasing mineral loss, biofilm viability, bacterial counts, and lactic acid production, demonstrating their potential as good alternatives for controlling this type of dental caries.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Amarett Kern, Tammy (White) Renteria, Marilynn L. Rothen, Lloyd A. Mancl, Peter Milgrom
Summary: In this study, a single application of SDF 38% did not significantly reduce gingivitis in dogs with stage two periodontal disease. However, both the SDF 38% treatment group and the placebo treatment group showed significant reductions in gingivitis scores relative to baseline, with a 53% reduction for the SDF group and a 44% reduction for the placebo group. There were no differences in Plaque Index or Calculus Index scores compared to the control groups. Further research is needed to explore the potential for more frequent applications or a longer study duration to potentially yield different results.
FRONTIERS IN VETERINARY SCIENCE
(2023)