Journal
STEM CELL RESEARCH & THERAPY
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13287-022-02822-2
Keywords
Mesenchymal stem cell; Pre-activation; Therapeutic potential; Individualized MSCs therapy
Funding
- National Nature Science Foundation of China [81971841, 81830064, 81721092, 81941021, 81901973]
- National Key Research and Development Plan [2017YFC1104701, 2017YFC1103304, 2018YFC2000400]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-059]
- Military Medical Research and Development Projects [AWS17J005, 2019-126]
- National S&T Resource Sharing service platform Project of China [YCZYPT[2018]07]
- General Hospital of PLA Medical Big Data RD Project [MBD2018030]
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This review summarizes the current approaches of MSC pre-activation, classifies and analyzes the scientific principles and main characteristics of these manipulations. In addition, the specialized tactics to solve the challenges in this field are discussed.
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.
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