Article
Infectious Diseases
Marisa Muadchimkaew, Taweegrit Siripongboonsitti, Saowanee Wongpatcharawarakul, Chanyapak Boonsankaew, Kriangkrai Tawinprai, Kamonwan Soonklang, Nithi Mahanonda
Summary: The study investigated the effectiveness of inactivated and ChAdOx1 nCoV-19 vaccination in preventing household transmission of SARS-CoV-2. The results showed that completing two doses of the SARS-CoV-2 vaccine within 14-90 days led to a significant reduction in household transmission. Wearing masks also played a role in reducing the risk of transmission.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Yves Michiels, Nadhira Houhou-Fidouh, Gilles Collin, Jerome Berger, Evelyne Kohli
Summary: The study demonstrated that a MS patient treated with teriflunomide showed a strong humoral response after receiving a ChAdOx1 nCoV-19/ BNT162b2 vaccination regimen, indicating that the medication did not hinder the development of an effective immune response to the vaccine.
Article
Virology
Emilie Catry, Julien Favresse, Constant Gillot, Jean-Louis Bayart, Damien Frerotte, Michel Dumonceaux, Patrick Evrard, Francois Mullier, Jonathan Douxfils, Francois M. Carlier, Melanie Closset
Summary: The immunogenicity of a two-dose ChAdOx1 nCoV-19 vaccine regimen was very poor in lung transplant recipients, but was significantly enhanced after the booster dose in one-third of the recipients. Immunosuppressants and high-dose corticosteroids were associated with a weak serological response.
Article
Multidisciplinary Sciences
Sue Ann Costa Clemens, Pedro M. Folegatti, Katherine R. W. Emary, Lily Yin Weckx, Jeremy Ratcliff, Sagida Bibi, Ana Verena De Almeida Mendes, Eveline Pipolo Milan, Ana Pittella, Alexandre Schwarzbold, Eduardo Sprinz, Parvinder K. Aley, David Bonsall, Christophe Fraser, Michelle Fuskova, Sarah C. Gilbert, Daniel Jenkin, Sarah Kelly, Simon Kerridge, Teresa Lambe, Natalie G. Marchevsky, Yama F. Mujadidi, Emma Plested, Maheshi N. Ramasamy, Peter Simmonds, Tanya Golubchik, Merryn Voysey, Andrew J. Pollard
Summary: A post-hoc analysis of a Phase 3 trial in Brazil showed that the ChAdOx1 nCoV-19 vaccine has high efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants, providing 95% protection against hospitalization.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Evangelos Terpos, Marianna Politou, Ioannis Ntanasis-Stathopoulos, Vangelis Karalis, Efrosyni Merkouri, Despina Fotiou, Maria Gavriatopoulou, Panagiotis Malandrakis, Efstathios Kastritis, Ioannis P. Trougakos, Meletios A. Dimopoulos
Summary: The study found that the ChAdOx1 nCov-19 vaccine can generate anti-PF4 antibodies in recipients even without thrombotic symptoms, but these antibodies are not enough to cause clinically evident thrombosis. This insight into the multifactorial pathophysiology of thrombotic events induced by the ChAdOx1 nCov-19 vaccine is crucial for ongoing investigations.
Review
Biochemistry & Molecular Biology
Jeong-Ju Yoo, Dong Keon Yon, Seung Won Lee, Jae Il Shin, Beom Kyung Kim
Summary: After SARS-CoV-2 vaccination, OLT recipients had a 70% humoral immune response rate, lower than healthy controls but favorable compared to other solid organ transplant recipients. Factors such as male sex, old age, chronic kidney disease, obesity, and high immunosuppressant doses increased the risk of unresponsiveness in OLT patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joana Barros-Martins, Swantje Hammerschmidt, Anne Cossmann, Ivan Odak, Metodi Stankov, Gema Morillas Ramos, Alexandra Dopfer-Jablonka, Annika Heidemann, Christiane Ritter, Michaela Friedrichsen, Christian Schultze-Florey, Inga Ravens, Stefanie Willenzon, Anja Bubke, Jasmin Ristenpart, Anika Janssen, George Ssebyatika, Gunter Bernhardt, Jan Muench, Markus Hoffmann, Stefan Poehlmann, Thomas Krey, Berislav Bosnjak, Reinhold Foerster, Georg M. N. Behrens
Summary: A study found that booster vaccination with BNT162b2 in healthcare professionals previously vaccinated with ChAdOx-1 nCoV-19 elicited more neutralizing antibodies and higher frequencies of virus-specific T cells. Additionally, BNT162b2 induced high titers of neutralizing antibodies against variants of concern, such as B.1.1.7, B.1.351, and P.1.
Article
Immunology
Sarinya Boongird, Chavachol Setthaudom, Rungthiwa Kitpermkiat, Somsak Prasongtanakij, Supanart Srisala, Piyatida Chuengsaman, Arkom Nongnuch, Montira Assanatham, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Jackrapong Bruminhent
Summary: This study assessed the changes in humoral and cell-mediated immunity in dialysis patients 6 months after receiving the COVID-19 vaccine. The results showed a significant decline in humoral immunity, while cell-mediated immunity remained stable. The study suggests considering a booster dose for dialysis patients 3 months after the initial vaccination.
Article
Immunology
Myeong Hee Kim, So Young Kang, Woo In Lee, Min Young Lee
Summary: We evaluated the immunogenicity of ChAdOx1 nCoV-19 vaccination by measuring SARS-CoV-2 IgG levels and studying the influence of factors such as gender, age, and adverse reactions. The study involved 1028 serum samples from 452 healthcare workers. SARS-CoV-2 IgG levels were measured using the SARS-CoV-2 IgG II Quant assay. Participants provided information on the intensity and duration of adverse reactions. The seropositive rates after the first and second doses were 95.5% and 100%, respectively. Median antibody levels showed a 4.2-fold increase after the second dose and a 3.5-fold decrease five months later.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Fuzhen Wang, Baoying Huang, Huakun Lv, Lizhong Feng, Weihong Ren, Xiaoqi Wang, Lin Tang, Qianqian Liu, Dan Wu, Hui Zheng, Zhijie An, Yao Deng, Li Zhao, Fei Ye, Wenling Wang, Hangjie Zhang, Shaoying Chang, Yuting Liao, Fengyang Chen, Lance E. Rodewald, George F. Gao, Zundong Yin, Wenjie Tan
Summary: This study evaluated neutralizing antibody titers and associated factors for the first 12 months after primary-series vaccination with BBIBP-CorV and CoronaVac. Results showed that over half of subjects were seropositive after 12 months, indicating the necessity of a six-month booster dose.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhe Zhang, Shipo Wu, Yawei Liu, Kailiang Li, Pengfei Fan, Xiaohong Song, Yudong Wang, Zhenghao Zhao, Xianwei Zhang, Jin Shang, Jinlong Zhang, Jinghan Xu, Yao Li, Yaohui Li, Jipeng Zhang, Kefan Fu, Busen Wang, Meng Hao, Guanying Zhang, Pengwei Long, Ziyu Qiu, Tao Zhu, Shuling Liu, Yue Zhang, Fangze Shao, Peng Lv, Yilong Yang, Xiaofan Zhao, Yufa Sun, Lihua Hou, Wei Chen
Summary: The study investigates the immune escape of the SARS-CoV-2 Omicron variant and evaluates the immune response of different types of booster vaccines. It finds that aerosolized Ad5-nCoV shows the most robust and long-lasting neutralizing activity and T-cell response against the Omicron variant.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pragya D. Yadav, Raches Ella, Sanjay Kumar, Dilip R. Patil, Sreelekshmy Mohandas, Anita M. Shete, Krishna M. Vadrevu, Gaurav Bhati, Gajanan Sapkal, Himanshu Kaushal, Savita Patil, Rajlaxmi Jain, Gururaj Deshpande, Nivedita Gupta, Kshitij Agarwal, Mangesh Gokhale, Basavaraj Mathapati, Siddhanath Metkari, Chandrashekhar Mote, Dimpal Nyayanit, Deepak Y. Patil, B. S. Sai Prasad, Annasaheb Suryawanshi, Manoj Kadam, Abhimanyu Kumar, Sachin Daigude, Sanjay Gopale, Triparna Majumdar, Deepak Mali, Prasad Sarkale, Shreekant Baradkar, Pranita Gawande, Yash Joshi, Sidharam Fulari, Hitesh Dighe, Sharda Sharma, Rashmi Gunjikar, Abhinendra Kumar, Kaumudi Kalele, Vellimedu K. Srinivas, Raman R. Gangakhedkar, Krishna M. Ella, Priya Abraham, Samiran Panda, Balram Bhargava
Summary: This study demonstrates the protective efficacy and immunogenicity of the inactivated SARS-CoV-2 vaccine BBV152 in rhesus macaques, indicating that the vaccine candidate is in clinical development.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Richard Tanner, Neasa Starr, Grace Chan, Eimear Dempsey, Emma Heffernan, Ellen Newman, James O'Neill, Margaret M. Hannan, Breda Lynch, Emer Joyce
Summary: This study aimed to explore the safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine in heart transplant recipients. The results showed that while a small number of patients who had previously been infected with SARS-CoV-2 had an immune response to the vaccine, the majority of patients without prior infection did not show a detectable antibody response.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Immunology
Marlene Pluess, Kemal Mese, Johannes T. Kowallick, Andreas Schuster, Desiree Tampe, Bjoern Tampe
Summary: As COVID-19 pandemic continues and new variants of SARS-CoV-2 emerge, there is an urgent need for vaccines to protect high-risk individuals and control disease outbreaks. Surveillance of rare safety issues related to these vaccines is underway. This article reports the first case of CMV reactivation and pericarditis associated with SARS-CoV-2 vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Bruno Pozzetto, Vincent Legros, Sophia Djebali, Veronique Barateau, Nicolas Guibert, Marine Villard, Loic Peyrot, Omran Allatif, Jean-Baptiste Fassier, Amelie Massardier-Pilonchery, Karen Brengel-Pesce, Melyssa Yaugel-Novoa, Solene Denolly, Bertrand Boson, Thomas Bourlet, Antonin Bal, Martine Valette, Thibault Andrieu, Bruno Lina, Francois-Loic Cosset, Stephane Paul, Thierry Defrance, Jacqueline Marvel, Thierry Walzer, Sophie Trouillet-Assant
Summary: The study found that a heterologous vaccination regimen using ChAdOx1-S-nCoV-19 and BNT162b2 can provide better protection against SARS-CoV-2 infection with stronger neutralizing activity. This approach can activate memory B cells that recognize SARS-CoV-2, making it suitable for immunocompromised individuals.
Article
Urology & Nephrology
Worapot Treamtrakanpon, Talerngsak Kanjanabuch, Tanawin Nopsopon, Piyatida Chuengsaman, Phongsak Dandecha, Sarinya Boongird, Kamol Khositrangsikun, Laddaporn Wongluechai, Sajja Tatiyanupanwong, Pongpratch Puapatanakul, Nattachai Srisawat, Somchai Eiam-Ong, David W. Johnson, Suchai Sritippayawan, Surasak Kantachuvesiri
Summary: The national survey in Thailand showed that acute peritoneal dialysis for acute kidney injury is underutilized, with major constraints including competency in PD catheter insertion, timely support for catheter insertion, and deficits in knowledge and competency among the medical supporting team.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Simon J. Davies, Junhui Zhao, Hal Morgenstern, Jarcy Zee, Brian Bieber, Douglas S. Fuller, James A. Sloand, Andreas Vychytil, Hideki Kawanishi, David W. Johnson, Angela Yee-Moon Wang, Talerngsak Kanjananbuch, Sarinya Boongird, Thyago P. Moraes, Sunil Badve, Ronald L. Pisoni, Jeffrey Perl
Summary: This study investigated international variation in hypokalemia and found that persistent hypokalemia is associated with higher mortality and peritonitis rates, even after extensive adjustment for patient factors. Further research is needed to understand the mechanisms of these poorer outcomes and modifiable risk factors for persistent hypokalemia.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Bunyong Phakdeekitcharoen, Watcharapong Treesinchai, Pornphan Wibulpolprasert, Sarinya Boongird, Pinkael Klytrayong
Summary: Our study showed that measuring GFR with iohexol is a more reliable and accurate method than using eGFR to evaluate changes in kidney function in early-stage ADPKD patients. There is a strong negative correlation between kidney volume and GFR in an Asian ADPKD population. The initial htTKV is a good predictor of kidney volume progression, while %Delta htTKV/y serves as a good early surrogate marker for renal function decline.
Article
Andrology
Potchara Kanammit, Pokket Sirisreetreerux, Sarinya Boongird, Suchin Worawichawong, Kittinut Kijvikai
Summary: ICG fluorescence videography is beneficial for detecting early ureteral ischemia in kidney transplantation patients with high accuracy and low risk of adverse events, providing important clinical assistance. However, further larger-scale studies are needed to confirm the results.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Surgery
Jackrapong Bruminhent, Chavachol Setthaudom, Pongsathon Chaumdee, Sarinya Boongird, Sasisopin Kiertiburanakul, Kumthorn Malathum, Arkom Nongnuch, Angsana Phuphuakrat, Sopon Jirasiritham, Chitimaporn Janphram, Sansanee Thotsiri, Supparat Upama, Montira Assanatham
Summary: Solid organ transplant recipients who received inactivated SARS-CoV-2 vaccination showed weak humoral immunity but comparable cell-mediated immunity responses compared to immunocompetent individuals.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Infectious Diseases
Sarinya Boongird, Piyatida Chuengsaman, Chavachol Setthaudom, Arkom Nongnuch, Montira Assanatham, Salinnart Phanprasert, Rungthiwa Kitpermkiat, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Andrew Davenport, Jackrapong Bruminhent
Summary: Patients with end-stage kidney disease (ESKD) had suboptimal humoral immune responses but comparable SARS-CoV-2-specific cell-mediated immune responses to healthy controls after two doses of SARS-CoV-2 vaccination. Old age, high ferritin level, and low absolute lymphocyte count were independently associated with poor humoral immune responses.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Urology & Nephrology
Mark Lambie, Junhui Zhao, Keith McCullough, Simon J. Davies, Hideki Kawanishi, David W. Johnson, James A. Sloand, Mauricio Sanabria, Talerngsak Kanjanabuch, Yong-Lim Kim, Jenny I. Shen, Ronald L. Pisoni, Bruce M. Robinson, Jeffrey Perl, PDOPPS Steering Comm
Summary: This study analyzes data from a multinational observational study to demonstrate the relationship between time on peritoneal dialysis and outcomes such as transfer to hemodialysis, death, and kidney transplantation. The study finds that countries with higher rates of kidney transplantation tend to have shorter median times on peritoneal dialysis, and infection is the leading cause of hemodialysis transfer.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Surgery
Jackrapong Bruminhent, Chavachol Setthaudom, Pattaraphorn Phornkittikorn, Pongsathon Chaumdee, Somsak Prasongtanakij, Supanart Srisala, Kumthorn Malathum, Sarinya Boongird, Arkom Nongnuch, Montira Assanatham, Laor Nakgul, Nutaporn Sanmeema, Angsana Phuphuakrat, Sasisopin Kiertiburanakul
Summary: In kidney transplant recipients, the immunogenicity following an additional dose of COVID-19 vaccine was investigated. The study found that there were no significant differences in immune responses between recipients of mRNA vaccines and viral vector vaccines, indicating both types of vaccines were effective in eliciting immunity in this population.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Sarinya Boongird, Chavachol Setthaudom, Rungthiwa Kitpermkiat, Somsak Prasongtanakij, Supanart Srisala, Piyatida Chuengsaman, Arkom Nongnuch, Montira Assanatham, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Jackrapong Bruminhent
Summary: This study assessed the changes in humoral and cell-mediated immunity in dialysis patients 6 months after receiving the COVID-19 vaccine. The results showed a significant decline in humoral immunity, while cell-mediated immunity remained stable. The study suggests considering a booster dose for dialysis patients 3 months after the initial vaccination.
Article
Public, Environmental & Occupational Health
Pornpen Sangthawan, Pinkaew Klyprayong, Sarayut L. Geater, Pimwara Tanvejsilp, Sirirat Anutrakulchai, Sarinya Boongird, Pongsathorn Gojaseni, Charan Kuhiran, Pichet Lorvinitnun, Kajohnsak Noppakun, Watanyu Parapiboon, Supinda Sirilak, Pluemjit Tankee, Puntapong Taruangsri, Pasuree Sangsupawanich, Piyamitr Sritara, Nathorn Chaiyakunapruk, Chagriya Kitiyakara
Summary: Universal health coverage can reduce the financial burden of chronic kidney disease for patients, but the residual financial hardship in low and middle-income countries has not been well-studied. This study in Thailand found that under the Universal Coverage Scheme, patients receiving hemodialysis had significantly higher medical expenditure compared to other stages of CKD, with travel costs being a major factor contributing to catastrophic health expenditure. Despite universal coverage, patients with kidney failure still faced high financial burden, especially in the poorest quintile.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Pattorn Hayuk, Sarinya Boongird, Prapaporn Pornsuriyasak, Jackrapong Bruminhent
Summary: Patients with chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), are at risk of developing tuberculosis (TB). The prevalence and predictors of latent tuberculosis infection (LTBI) assessed by high-sensitivity, high-specificity tests like an interferon-gamma release assay (IGRA) have not been thoroughly explored.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Piyatida Chuengsaman, Sarinya Boongird, Phongsak Dandecha, Thiravat Hemachudha, Tanawin Nopsopon, Talerngsak Kanjanabuch, Suchai Sritippayawan, Surasak Kantachuvesiri
Summary: This nationwide cohort study assessed the fatality rate and factors associated with death among peritoneal dialysis (PD) patients during COVID-19. The study found a high COVID-19-related fatality rate in PD patients, with similar predictors of death as in hemodialysis patients. PD patients commonly experienced functional deterioration during COVID-19.
FRONTIERS IN MEDICINE
(2022)
Correction
Urology & Nephrology
Simon J. Davies, Junhui Zhao, Hal Morgenstern, Jarcy Zee, Brian Bieber, Douglas S. Fuller, James A. Sloand, Andreas Vychytil, Hideki Kawanishi, David W. Johnson, Angela Yee-Moon Wang, Talerngsak Kanjanabuch, Sarinya Boongird, Thyago P. Moraes, Sunil V. Badve, Ronald L. Pisoni, Jeffrey Perl
KIDNEY INTERNATIONAL REPORTS
(2021)
Meeting Abstract
Urology & Nephrology
Ittikorn Spanuchart, Chalothorn Taesilapasathit, Kanin Thammavaranucupt, Supawadee Suppadungsuk, Arkom Nongnuch, Sarinya Boongird