The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro

Add-on azithromycin reduces sputum cytokines in non-eosinophilic asthma: an AMAZES substudy

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Prediction of response to biological treatment with monoclonal antibodies in severe asthma

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Interleukins 6/8 and cyclooxygenase-2 release and expressions are regulated by oxidative stress-JAK2/STAT3 signaling pathway in human bronchial epithelial cells exposed to particulate matter ≤2.5 μm

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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

(2020) Kurt A. Schalper et al.   NATURE MEDICINE

Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation

(2020) Viviana Marzaioli et al.   Frontiers in Immunology

Long-term therapy response to anti-interleukin-5 biologics in severe asthma – a real-life evaluation

(2020) Katrien Eger et al.   Journal of Allergy and Clinical Immunology-In Practice

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(2020) Shankar J. Evani et al.   Scientific Reports

The Relationship of Asthma Biologics to Remission for Asthma

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(2019) Christopher Brightling et al.   EUROPEAN RESPIRATORY JOURNAL

Novel inhaled pan-JAK inhibitor, LAS194046, reduces allergen-induced airway inflammation, late asthmatic response and pSTATs activation in Brown Norway rats.

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Pharmacological strategies to regain steroid sensitivity in severe asthma and COPD

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Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models

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Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells

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Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS

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Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease

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Bafetinib inhibits functional responses of human eosinophils in vitro

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Toll-Like Receptor 4-Linked Janus Kinase 2 Signaling Contributes to Internalization of Brucella abortus by Macrophages

(2013) Jin Ju Lee et al.   INFECTION AND IMMUNITY

Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses

(2013) Shigeru Ashino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chemokine to the Rescue: Interleukin-8 Mediates Resistance to PI3K-Pathway-Targeted Therapy in Breast Cancer

(2012) Robert T. Abraham   CANCER CELL

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(2012) Sally E Wenzel   NATURE MEDICINE

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Identification of NURR1 as a Mediator of MIF Signaling During Chronic Arthritis

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(2010) Peter J. Barnes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

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Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

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Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

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JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

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Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis

(2009) Javier Milara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

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A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

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