Article
Chemistry, Medicinal
Fatma Abo-Elghiet, Amal H. Ahmed, Hanan F. Aly, Eman A. Younis, Mohamed A. Rabeh, Saad Ali Alshehri, Khalid S. A. Alshahrani, Shaza A. Mohamed
Summary: This study evaluated the D-pinitol content and DPPH radical-scavenging activity of methanolic leaves extracts of five cultivars of Bougainvillea spectabilis. The effects of these cultivars on various parameters in STZ-induced diabetic rats were assessed after one month of oral daily treatment. All tested cultivars showed significant improvements in the measured parameters, with the LOE cultivar exhibiting the highest efficacy and D-pinitol concentration.
Article
Pharmacology & Pharmacy
Juan A. Navarro, Juan Decara, Dina Medina-Vera, Ruben Tovar, Antonio J. Lopez-Gambero, Juan Suarez, Francisco Javier Pavon, Antonia Serrano, Marialuisa de Ceglia, Carlos Sanjuan, Yolanda Alfonso Baltasar, Elena Baixeras, Fernando Rodriguez de Fonseca
Summary: The use of added sugars and non-nutritive sweeteners in processed foods poses challenges for treating obesity and diabetes. Fructose contributes to obesity and liver steatosis, while non-nutritive sweeteners disrupt gut bacteria and metabolic control. This study proposes an alternative sweetener derived from carob pods, which contains a balanced mixture of fructose and glucose as sweetening sugars, and a functional natural ingredient (D-Pinitol) that produces positive metabolic effects.
Article
Pharmacology & Pharmacy
Dina Medina-Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell-Valle, Alfonso Gutierrez-Adan, Carlos Sanjuan, Antonio Jesus Lopez-Gambero, Ruben Tovar, Juan Suarez, Francisco Javier Pavon, Elena Baixeras, Juan Decara, Fernando Rodriguez de Fonseca
Summary: This study found that d-pinitol inositol can lower tau protein phosphorylation levels by regulating CDK5 activity. This suggests that d-pinitol could be a potential drug for treating neurological disorders such as tauopathies.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonio Simone Lagana, Gianpiero Forte, Mariano Bizzarri, Zdravko A. Kamenov, Bianca Bianco, Cihan Kaya, Georgios Gitas, Ibrahim Alkatout, Milan Terzic, Vittorio Unfer
Summary: MI and DCI play key roles in ovarian physiology and steroid biosynthesis. Imbalance of MI-to-DCI ratio may lead to gynecological disorders. Proper evaluation of inositol treatments and their effects on different PCOS phenotypes are important.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Juan A. Navarro, Caridad Diaz, Juan Decara, Dina Medina-Vera, Antonio J. Lopez-Gambero, Juan Suarez, Francisco Javier Pavon, Antonia Serrano, Antonio Vargas, Ana Luisa Gavito, Oscar Porras-Perales, Jesus Aranda, Francisca Vicente, Carlos Sanjuan, Elena Baixeras, Fernando Rodriguez de Fonseca
Summary: This study characterizes the oral pharmacokinetics of D-Pinitol in human healthy volunteers and suggests its potential importance as an endocrine pancreas protector for the treatment or prevention of insulin resistance-associated conditions.
Article
Nutrition & Dietetics
Dina Medina-Vera, Juan Antonio Navarro, Ruben Tovar, Cristina Rosell-Valle, Alfonso Gutierrez-Adan, Juan Carlos Ledesma, Carlos Sanjuan, Francisco Javier Pavon, Elena Baixeras, Fernando Rodriguez de Fonseca, Juan Decara
Summary: The study demonstrates that DPIN activates the insulin pathway in the hypothalamus through the PI3K/Akt cascade, leading to phosphorylation of key proteins and a decrease in circulating insulin levels. This indicates that DPIN may be a potential treatment for brain insulin-resistance associated disorders by enhancing insulin response beyond the insulin receptor.
Review
Pharmacology & Pharmacy
Tina Nie, Garth J. S. Cooper
Summary: Polyphenolic compounds show promise in treating type 2 diabetes by inhibiting hA aggregation and modulating oxidative stress and inflammation pathways that affect beta-cell disruption. Further research is needed to determine their potential as a therapeutic option for T2DM.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Mrunmai Tapadia, Stuart Johnson, Ranjeet Utikar, Philip Newsholme, Rodrigo Carlessi
Summary: The gamma-conglutin peptides showed a potential insulin-mimetic action in muscle cells by activating insulin signaling pathways and also effectively inhibited DPP4 activity, indicating their potential to prolong the half-life of incretin hormones in circulation. These results support the health benefits of consuming lupin seeds and suggest a shift in the market towards lupin-based food products for human consumption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Geriatrics & Gerontology
Xiaomei Du, Yichun Wang, Jilite Wang, Xiaozhi Liu, Jingnan Chen, Ji Kang, Xu Yang, Hao Wang
Summary: D-Chiro-Inositol (DCI) and D-Pinitol (DP) have positive effects on lifespan and antioxidant activity in Drosophila melanogaster. DCI shows slightly better effects than DP. The prolongation of lifespan by DCI and DP is achieved through regulating intestinal homeostasis and inhibiting abnormal proliferation of intestinal stem cells. Insulin signaling pathway and autophagy pathway are involved in the longevity-promoting effects of DCI and DP.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ijaz Muhammad, Noor Rahman, Gul-E-Nayab, Umar Nishan, Mohibullah Shah
Summary: Diabetes mellitus, a metabolic disorder affecting a large part of the world's population, has been treated with traditional medicine which is believed to have a promising future. Phytochemicals, particularly alkaloids and their derivatives, have shown potential as effective agents against diabetes. Future efforts should focus on rigorous clinical studies, development, and identification of drug targets for alkaloids in the treatment of diabetes.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Ebrahim Abbasi, Iraj Khodadadi
Summary: Studies have shown that soybean and isoflavones can reduce the risk of diabetes. Genistein, an isoflavone, has been found to inhibit hepatic glucose production, increase β-cell proliferation, reduce β-cell apoptosis, and exhibit potential antioxidant and anti-diabetic effects, making it useful in managing diabetes.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Miaosi Zhang, Zhe Xu, Liangyong Shao, Jilite Wang, Zouyan He, Yumei Jiang, Ye Zhang, Hao Wang
Summary: D-pinitol (DP) has been identified as a potential anti-aging drug. It has been found to delay cellular senescence, increase antioxidant enzyme activity, and decrease oxidative stress in both cell and nematode models. DP also enhances longevity, stress capacity, and antioxidant capacity in nematodes, while altering aging-related indicators. Mechanistic studies reveal that DP extends lifespan through the insulin/insulin-like growth factor-1 signaling (IIS) pathway by increasing the expression of transcription factors.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Riccardo Gambioli, Mario Montanino Oliva, Maurizio Nordio, Alfonsina Chiefari, Giulia Puliani, Vittorio Unfer
Summary: D-chiro-inositol is a natural compound found in cell membranes, primarily involved in intracellular insulin transduction cascade in mammals. It also plays a role in regulating steroidogenesis, reducing adhesion molecule expression, and exerting anti-inflammatory activities. Research on this molecule is crucial due to its involvement in several fundamental physiological processes.
Article
Endocrinology & Metabolism
Vishal Musale, R. Charlotte Moffett, Bosede Owolabi, J. Michael Conlon, Peter R. Flatt, Yasser H. A. Abdel-Wahab
Summary: The study investigated the antidiabetic effects and mechanisms of action of [S4K]CPF-AM1 peptide in db/db mice, showing significant improvements in blood glucose, HbA1c levels, plasma insulin concentration, insulin sensitivity, and insulin secretion and action. Additionally, the peptide treatment also led to a reduction in abnormal biomarkers associated with liver and kidney function in the db/db mice.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2021)
Review
Integrative & Complementary Medicine
Berhan Begashaw Yikna, Awgichew Shewasinad Yehualashet
Summary: This study synthesizes the potential antidiabetic activities of medicinal plants in Ethiopia based on in vitro and in vivo evaluations of extracts and fractions. It provides comprehensive evidence on the effectiveness of these herbal medicines, recommending further pharmacological and toxicological investigations and suggesting their potential for future development of novel antidiabetic drugs in clinical studies.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)