Article
Chemistry, Multidisciplinary
Nelson Adrian Villacres, Eder T. G. Cavalheiro, Carla C. Schmitt, Tiago Venancio, Hugo A. Alarcon, Ana C. Valderrama
Summary: This research aimed to extract sodium alginate from brown algae Macrocystis pyrifera and Lessonia trabeculata, and produce composite films composed of sodium alginate/ kappa-carrageenan/ iota-carrageenan, which were loaded with aminoethoxyvinylglycine. The extracted sodium alginate had low molecular weight and the composite films showed desirable drug release properties. Therefore, sodium alginate can be used to prepare composite films as an alternative to synthetic polymers for drug loading and release.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Environmental Sciences
Christina A. Frieder, Chao Yan, Marcelo Chamecki, Daniel Dauhajre, James C. McWilliams, Javier Infante, Meredith L. McPherson, Raphael M. Kudela, Faycal Kessouri, Martha Sutula, Isabella B. Arzeno-Soltero, Kristen A. Davis
Summary: This article presents a computational modeling framework called MACMODS for studying the growth and yield of macroalgae in offshore aquaculture environments. By simulating changes in light, seawater flow, and nutrient fields, insights can be provided to farmers on how farm design and regional ocean conditions interact to influence overall yield.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Polymer Science
Lini Wang, Hui Jie Zhang, Xinyi Wang, Wenying Zhao, Weihua Yan, Fangjian Zhang, Yanjun Li, Xiangyu You
Summary: This study successfully prepared low-calorie, high satiety, and easy-to-digest edible hydrogels, which exhibited excellent mechanical properties and thermal expansion. These hydrogels have the potential to be used as low-calorie food due to their unique properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Lini Wang, Hui Jie Zhang, Xueqian Liu, Yun Liu, Xing Zhu, Xinhua Liu, Xiangyu You
Summary: In this study, hydrogels composed of gelatin and sodium alginate were successfully constructed through a simple acid soaking-drying-swelling process, showing good mechanical performance, biocompatibility, and ionic conductivity.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Mojde Moradi Pour, Roohallah Saberi-Riseh, Keyvan Esmaeilzadeh-Salestani, Reza Mohammadinejad, Evelin Loit
Summary: The study presents an intelligent formulation based on Bacillus velezensis encapsulation enriched with nanoparticles that can control Rhizoctonia solani, which shows promising potential in promoting plant growth effectively.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Rui Cui, Bifen Zhu, Jiatong Yan, Yuyue Qin, Mingwei Yuan, Guiguang Cheng, Minglong Yuan
Summary: The study prepared antimicrobial food packaging film with controlled release by loading cinnamaldehyde on etched halloysite nanotubes and adding it to sodium alginate matrix. The film showed improved water vapor barrier properties, tensile strength, and reduced negative effects of UV rays. Controlled release of cinnamaldehyde in the film was confirmed, suggesting broad application prospects in fatty food packaging.
Article
Engineering, Biomedical
Amit Kumar Singh, Krishna Pramanik, Amit Biswas
Summary: In this study, a SA/CH/GE tri-polymer complex was used as a bioink to fabricate a scaffold suitable for bone-tissue regeneration through 3D printing. The addition of gelatin improved the mechanical properties, structural stability, protein adsorption, and cellular adhesion of the scaffold. It also exhibited desirable degradation rate and controlled swelling properties.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Biochemistry & Molecular Biology
A. I. Abd-Elhamid, E. M. Abu Elgoud, H. F. Aly
Summary: The adsorption characteristics of palladium from chloride aqueous solution onto the silica alginate (SA-Si) nanomaterial have been studied. The experiment showed that the pseudo-first-order model provided the best fitting for the adsorption of palladium ions, with an equilibrium time of 90.0 min. The Langmuir isotherm model was able to describe the adsorption isotherm result well, with a maximum adsorption capacity of 12.50 mg/g for Pd(II) on the SA-Si nanomaterial. Thermodynamic results indicated that the sorption of Pd(II) onto the SA-Si nanomaterial was endothermic and spontaneous. Additionally, the SA-Si nanomaterial showed effective adsorption for Pd(II) from various metal ions present in fission products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Xiaohong Chen, Linzi Li, Lin Chen, Wei Shao, Yan Chen, Xiaojing Fan, Yaping Liu, Changbo Tang, Shijie Ding, Xinglian Xu, Guanghong Zhou, Xianchao Feng
Summary: This study aimed to construct block-shaped cell culture meat by using edible scaffolds as a platform for animal stem cell expansion. The tea polyphenols (TP)-coated 3D scaffolds, composed of sodium alginate (SA) and gelatin (Gel), showed good biocompatibility and mechanical support. Rabbit skeletal muscle myoblasts exhibited good adhesion and extension behavior on the TP-coated scaffolds with high expression of myogenic differentiation proteins and genes. The scaffolds with TP coating significantly improved cell proliferation rate and morphology, indicating their high potential for cultured meat production.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Abudureheman Maihemuti, Han Zhang, Xiang Lin, Yangyufan Wang, Zhihong Xu, Dagan Zhang, Qing Jiang
Summary: In this study, a three-dimensional printed porous multilayer scaffold made of cold-water fish skin gelatin was developed for osteoarticular cartilage regeneration. The scaffold mimics the structure of native cartilage, allowing chondrocytes to adhere, proliferate, and communicate, as well as transport nutrients and prevent further joint damage. Moreover, the gelatin scaffolds were found to be nonimmunogenic, nontoxic, and biodegradable. Implanting the scaffold into rat cartilage defects resulted in satisfactory repair outcomes in an animal model. Therefore, cold-water fish skin gelatin scaffolds have promising applications in regenerative medicine.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Sean Scott, Jason Terreblanche, Dana L. Thompson, Chunhong Lei, Jennifer M. Hartley, Andrew P. Abbott, Karl S. Ryder
Summary: Water-soluble biopolymers gelatin and sodium alginate modified with a deep eutectic solvent were investigated as potential alternative binders for lithium-ion battery anodes. The modified binders showed improved plasticity and adhesion compared to unmodified binders and commonly used PVDF or CMC/SBR binders. Both modified gelatin and sodium alginate binders can disperse in water and be rapidly delaminated with mild ultrasound. Microscopy imaging revealed different dispersion behaviors of the two binders around graphite particles.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Materials Science, Multidisciplinary
Trainitid Tiraton, Orawan Suwantong, Piyachat Chuysinuan, Pongpol Ekabutr, Pimolpun Niamlang, Thitikan Khampieng, Pitt Supaphol
Summary: A novel sodium alginate-gelatin microneedles patch containing clindamycin was developed for acne treatment. The microneedles exhibited different mechanical properties, densities, and release patterns, with clindamycin-loaded microneedles effectively inhibiting the growth of acne-causing bacteria and being non-toxic to normal skin cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kubra Akin, Volkan Ugraskan, Birol Isik, Fatih Cakar
Summary: This study investigated the performance of montmorillonite-filled SA-GEL-MMT ternary biocomposite microbeads in the adsorptive removal of crystal violet dye. The maximum removal of the dye was found to be 92.1% under specific conditions. The kinetic studies showed that the adsorption of the dye followed pseudo-second-order kinetics. The use of SA-GEL-MMT was found to be highly effective and reusable for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Umar Aslam Khan, Goran M. Stojanovic, Roselinda Ab Rehman, Ali-Reza Moradi, Muhammad Rizwan, Nureddin Ashammakhi, Anwarul Hasan
Summary: Biopolymer-based bioactive hydrogels exhibit excellent properties for wound healing applications. The study explored the synthesis and characterization of bioactive hydrogels made from bacterial cellulose and gelatin. The hydrogels demonstrated desirable swelling behavior, controlled drug release kinetics, and showed good cell compatibility and antibacterial activity.
Article
Engineering, Biomedical
Fenyan Miao, Tingting Liu, Xiumei Zhang, Xuefeng Wang, Yan Wei, Yinchun Hu, Xiaojie Lian, Liqin Zhao, Weiyi Chen, Di Huang
Summary: In this study, GelMA and Alg were used to prepare a hydrogel scaffold that mimics the structure and function of natural extracellular matrix, and the physical properties and osteoinductivity were enhanced by mineralization with hydroxyapatite (HA). The mineral content and compressive strength of the mineralized hydrogel were significantly improved, confirming the potential of the GelMA/Alg-HA hydrogel for bone regeneration.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Review
Biochemistry & Molecular Biology
Roohallah Saberi Riseh, Mohadeseh Hassanisaadi, Masoumeh Vatankhah, Somayeh Abdani Babaki, Essaid Ait Barka
Summary: Due to the awareness of pesticide dangers, the necessity for non-chemical approaches has grown. Chitosan, a biopolymer, is an effective choice in phytopathology due to its biocompatibility, biodegradability, and bioactivity. Chitosan reduces plant diseases through direct antimicrobial function and induction of plant defense responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Yury A. Skorik
Summary: This review discusses the approaches and techniques for improving the biopharmaceutical properties of topical corticosteroids using mucoadhesive polymer patches. It focuses on increasing bioadhesion, modifying drug release, and improving local bioavailability and safety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Otorhinolaryngology
L. Q. Li, O. Hilmi, J. England, N. Tolley
Summary: This review aims to provide an overview of currently accepted practices for the initial investigation and subsequent management of patients with thyroid nodules for non-specialists, as well as address the areas of variation between common clinical systems and newer technologies in the evaluation of malignancy in thyroid nodules.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Article
Chemistry, Physical
Natallia Dubashynskaya, Valentina A. Petrova, Dmitry P. Romanov, Yury A. Skorik
Summary: The study focuses on the development of hydrogels based on partially deacetylated chitin nanowhiskers (CNWs) and sodium alginate (ALG) for potential vaginal administration, providing controlled pH-dependent antibiotic release and prolonged pharmacological action. The desired hydrogels were formed through electrostatic interactions and molecular entanglement. In vitro release studies showed prolonged pH-sensitive drug release from the designed hydrogels.
Article
Chemistry, Analytical
Mojde Moradi Pour, Roohallah Saberi Riseh, Reza Ranjbar-Karimi, Mohadeseh Hassanisaadi, Abbas Rahdar, Francesco Baino
Summary: This study aimed to improve the performance of biological agents under adverse environmental conditions by encapsulating Bacillus velezensis in novel nanocomposites. The results showed that the multilayer formulation had the highest encapsulation efficiency and good compatibility of materials.
Article
Agronomy
Roohallah Saberi Riseh, Elahe Tamanadar, Najmeh Hajabdollahi, Masoumeh Vatankhah, Vijay Kumar Thakur, Yury A. Skorik
Summary: Chitosan, a candidate polymer for agricultural purposes, is biocompatible with other materials, easily digested and dissolved, non-toxic, highly adsorbent, and potentially biodegradable. It has become important in various industries. In agriculture, chitosan effectively solves the main problems of bacterial encapsulation, but further research is needed to improve encapsulation precision.
Article
Biochemistry & Molecular Biology
Valentina A. Petrova, Natallia V. Dubashynskaya, Iosif V. Gofman, Alexey S. Golovkin, Alexander I. Mishanin, Arthur D. Aquino, Daria V. Mukhametdinova, Alexandra L. Nikolaeva, Elena M. Ivan'kova, Alexander E. Baranchikov, Alexander V. Yakimansky, Vladimir K. Ivanov, Yury A. Skorik
Summary: Polymeric nanocomposite materials have the potential to enhance tissue-engineered scaffolds by influencing the structure and properties of polymeric materials and regulating cell behavior. In this study, cerium oxide nanoparticles were incorporated into a chitosan film to promote the proliferation of mesenchymal stem cells. The resulting CS-CeONP films exhibited good biocompatibility and regenerative potential in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Natallia V. V. Dubashynskaya, Anton N. N. Bokatyi, Anatoliy V. V. Dobrodumov, Igor V. V. Kudryavtsev, Andrey S. S. Trulioff, Artem A. A. Rubinstein, Arthur D. D. Aquino, Yaroslav A. A. Dubrovskii, Elena S. S. Knyazeva, Elena V. V. Demyanova, Yuliya A. A. Nashchekina, Yury A. A. Skorik
Summary: The growth of microbial multidrug resistance is a problem in modern clinical medicine. Chemical modification of active pharmaceutical ingredients is an attractive strategy to improve their biopharmaceutical properties. Conjugation of antimicrobial drugs with natural polysaccharides provides targeted delivery, controlled drug release, and reduced toxicity. The study synthesized colistin conjugates with succinyl chitosan and found promising results in terms of drug release, antimicrobial activity, and reduction of drug nephrotoxicity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Natallia V. V. Dubashynskaya, Ekaterina R. R. Gasilova, Yury A. A. Skorik
Summary: The marine polysaccharide fucoidan (FUC) shows great potential in pharmaceutical research for developing drug delivery systems with modified release and targeted delivery. The presence of a sulfate group in FUC makes it suitable for forming interpolyelectrolyte complexes (PECs) with various polycations. However, the structural diversity of FUC poses challenges in designing FUC-based nanoformulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valentina A. A. Petrova, Iosif V. V. Gofman, Natallia V. V. Dubashynskaya, Alexey S. S. Golovkin, Alexander I. I. Mishanin, Elena M. M. Ivan'kova, Dmitry P. P. Romanov, Albert K. K. Khripunov, Elena N. N. Vlasova, Alexandra V. V. Migunova, Alexander E. E. Baranchikov, Vladimir K. K. Ivanov, Alexander V. V. Yakimansky, Yury A. A. Skorik
Summary: New composite films were prepared by incorporating bacterial cellulose nanofibers and cerium oxide nanoparticles into chitosan matrices. The amount of nanofillers affected the structure and properties of the composites, including film stiffness and strength. Increasing the concentration of nanoceria improved the biocompatibility and adhesion of the films to mesenchymal stem cells. These nanocomposite films exhibit favorable properties for use as matrix materials in cell culture and wound dressings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Natallia V. V. Dubashynskaya, Valentina A. A. Petrova, Andrey V. V. Sgibnev, Vladimir Y. Y. Elokhovskiy, Yuliya I. I. Cherkasova, Yury A. A. Skorik
Summary: The development of cryogels containing metronidazole (MET) based on carrageenan (CRG) and partially deacetylated chitin nanowhiskers (CNWs) has shown promise for improved vaginal delivery. The incorporation of CNWs significantly improved the strength and homogeneity of the cryogels, resulting in sustained drug release within 24 hours. The mechanism of prolonged release was related to polymer swelling and chain relaxation in the matrix, as demonstrated by the Korsmeyer-Peppas and Peppas-Sahlin models. These cryogels exhibited a prolonged antiprotozoal effect, making them potential dosage forms for the treatment of vaginal infections.
Article
Chemistry, Analytical
Tatiana Zimina, Nikita Sitkov, Vladimir Karasev, Yury Skorik, Alexey Kolobov, Alexander Kolobov, Nikolay Bunenkov, Viktor Luchinin
Summary: The study used in silico modelling to simulate peptides complementary to lactoferrin, specifically focusing on the bonding site between pneumococcal surface protein (PSP) and lactoferrin (LF). The proposed peptide, EEVAPQAQAKIAELENQVHRLE, was synthesized and analyzed to confirm its purity. Experimental results showed that the peptide formed a complex with LF, leading to a change in mobility. However, no binding was observed with homomyeloperoxidase and myoglobin.
Article
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Anton N. Bokatyi, Tatiana S. Sall, Tatiana S. Egorova, Yuliya A. Nashchekina, Yaroslav A. Dubrovskii, Ekaterina A. Murashko, Elena N. Vlasova, Elena V. Demyanova, Yury A. Skorik
Summary: Polymeric drug delivery systems enhance the properties of antibiotics by increasing bioavailability, providing controlled-release, and reducing toxicity. This study describes the modification of conjugates based on colistin and hyaluronic acid with vitamin B12, which improved intestinal permeability, achieved slow release, and retained antimicrobial activity. These vitamin B12-modified conjugates may be promising oral delivery systems with improved biopharmaceutical properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Natallia V. Dubashynskaya, Anton N. Bokatyi, Andrey S. Trulioff, Artem A. Rubinstein, Igor V. Kudryavtsev, Yury A. Skorik
Summary: This study aimed to develop a dexamethasone phosphate delivery system based on hyaluronic acid and a cationic chitosan derivative, which showed both excellent mucoadhesion and prolonged drug release.
