Article
Medicine, General & Internal
Rodolfo Mastropasqua, Rossella D'Aloisio, Erica Costantini, Annamaria Porreca, Giada Ferro, Daniele Libertini, Marcella Reale, Marta Di Nicola, Pasquale Viggiano, Gennaro Falconio, Lisa Toto
Summary: The study evaluated the expression levels of different miRNAs in diabetic patients and found significant differences in expression levels between diabetic patients with and without DR. Significant associations between miRNAs and anatomical/perfusion parameters and functional parameters were observed in the diabetic groups.
Article
Engineering, Environmental
Qian Li, Guofu Zhang, Lixia Lin, Meng Wu, Xiyu Cao, Daxiang Xiao, Xiaoyi Wang, Xu Zhang, Shangzhi Xu, Xiating Li, Chunrong Zhong, Tianqi Tan, Xi Chen, Li Huang, Yu Zhang, Renjuan Chen, Xuezhen Zhou, Ting Xiong, Yuanjue Wu, Qin Gao, Jiangyue Wu, De Li, Wenli Cui, Menghan Tu, Huaqi Zhang, Siyu Yang, Jin Liu, Hongying Yang, Xuefeng Yang, Liping Hao, Nianhong Yang
Summary: This study found that higher plasma Mn levels in early pregnancy are associated with increased risk of gestational diabetes mellitus (GDM).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Nicole N. Noren Hooten, Nicolle A. A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. B. Zonderman, Ngozi Ezike, Mark J. J. DiNubile, Susan K. L. Levinson, Michele K. K. Evans
Summary: This study found differences in plasma gelsolin levels among individuals with and without diabetes, and these differences were associated with sex, race, and poverty. Additionally, gelsolin was significantly associated with adiponectin, an adipokine, and other inflammation- and diabetes-related proteins. These findings provide mechanistic insights into the relationship between gelsolin and diabetes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ibrahim Bekir Boz, Semra Ayturk Salt, Omer Salt, Niyazi Cenk Sayin, Ilker Dibirdik
Summary: This study found that serum asprosin levels can potentially be used as a marker in the diagnosis of GDM, and provided support through the investigation of related parameters.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Environmental Sciences
Hongli Nie, Hua Hu, Zhaoyang Li, Ruixin Wang, Jia He, Peiwen Li, Weiya Li, Xu Cheng, Jun An, Zefang Zhang, Jiao Bi, Jinqiu Yao, Huan Guo, Xiaomin Zhang, Meian He
Summary: This study found significant associations between several plasma metal levels and diabetes risk, as well as certain plasma miRNAs being related to diabetes risk. MiR-122-5p mediated the relationship between titanium and diabetes risk by 48.0%.
ENVIRONMENTAL POLLUTION
(2022)
Article
Obstetrics & Gynecology
Jing Ji, Pei Wu, Guohua Li, Zhangya He, Shanshan Wang, Wenlu Yu, Chao Li, Yang Mi, Xiaoqin Luo
Summary: This study examines the changes in biochemical levels during pregnancy in women with GDM and identifies indicators that play a role in predicting birth weight.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Endocrinology & Metabolism
Mingcan Zhao, Yuandong Xie, Wenjia Gao, Chunwang Li, Qiang Ye, Yi Li
Summary: Diabetes mellitus is a main risk factor for periodontitis, but the underlying molecular mechanisms remain unclear. Diabetes can increase the pathogenicity of the periodontal microbiota and the inflammatory/host immune response of the periodontium. Hyperglycemia induces oxidative stress, exacerbating periodontal tissue destruction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
A. Adam-Artigues, I Garrido-Cano, S. Simon, B. Ortega, S. Moragon, A. Lameirinhas, V Constancio, S. Salta, O. Burgues, B. Bermejo, R. Henrique, A. Lluch, C. Jeronimo, P. Eroles, J. M. Cejalvo
Summary: miR-30b-5p expression in breast cancer tissue and plasma differs significantly from healthy samples, with higher levels in plasma of BC patients. This miRNA demonstrates good potential for early diagnosis of breast cancer.
Review
Pharmacology & Pharmacy
Zhu-Qiu Jin
Summary: Cardiac fibrosis, a main characteristic of diabetic cardiomyopathy, is influenced by multiple signaling pathways, with TGF-beta/Smad2/3 pathway playing a central role. miRNAs, stable molecules involved in gene silencing, are dysregulated in the diabetic heart, promoting or inhibiting cardiac fibrosis by targeting various pathways in different cardiac cells. Detection of miRNAs in plasma or serum could potentially serve as biomarkers for diabetes mellitus or heart failure diagnosis, providing insight into the pathogenesis of cardiac fibrosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Simone Bini, Laura D'Erasmo, Brenno Astiarraga, Ilenia Minicocci, Maria Palumbo, Valeria Pecce, Luca Polito, Alessia Di Costanzo, Rebecca A. Haeusler, Marcello Arca, Ele Ferrannini, Stefania Camastra
Summary: This study evaluated the impact of bariatric surgery on plasma levels of two regulators of triglyceride storage and utilization, ANGPTL3 and ANGPTL4. The results showed that bariatric surgery led to improved insulin sensitivity and decreased levels of ANGPTL4. However, the changes in ANGPTL3 levels depended on the specific surgical procedure.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Medicine, General & Internal
Wenqian Lu, Cheng Hu
Summary: This review summarizes recent studies on biomolecules associated with GDM and postpartum diabetes, focusing on their predictive value in screening and diagnosis.
CHINESE MEDICAL JOURNAL
(2022)
Review
Medicine, General & Internal
Hanyue Ding, Junjie Huang, Yunyang Deng, Sze Pui Pamela Tin, Martin Chi-Sang Wong, Eng-kiong Yeoh
Summary: This systematic review examines the characteristics of participants in screening programs for blood glucose tests, lipid profiles, or a combination of both. The review finds that individuals from lower socioeconomic backgrounds are less likely to participate in diabetes and/or lipid screening in developed areas, and these populations are at higher risk of non-communicable diseases. Future studies should focus on understanding the barriers and facilitators of screening among non-participants and develop targeted interventions to improve screening uptake.
Article
Medicine, General & Internal
Hao-Chang Hung, Hung-Tsung Wu, Ching-Han Lin, Hsuan-Wen Chou, Horng-Yih Ou, Chih-Jen Chang
Summary: GDF15, a stress-response cytokine, is associated with different glycemic statuses in non-obese subjects. Those with isolated IFG and NDD have higher GDF15 levels, which are positively correlated with A1C.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Obstetrics & Gynecology
Serkan Oral, Sebahattin Celik, Yasam Kemal Akpak, Hakan Golbasi, Burak Bayraktar, Gokhan Unver, Sami Sahin, Nazan Yurtcu, Canan Soyer Caliskan
Summary: This study aimed to evaluate the association between maternal plasma zonulin levels and gestational diabetes mellitus (GDM) and its perinatal outcomes. The results showed that zonulin levels were significantly higher in pregnant women with GDM and were associated with increased body mass index (BMI) and adverse perinatal outcomes. Zonulin may be a potential marker for predicting the risk of GDM and perinatal outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
