Review
Immunology
Shuang Fan, Wen-Xuan Huo, Yang Yang, Meng-Zhu Shen, Xiao-Dong Mo
Summary: This study reports the updated results of ruxolitinib as treatment for SR-GVHD and compares the efficacy and safety between children and adults. The findings suggest that ruxolitinib is an effective and safe treatment for SR-GVHD, and both children and adults can benefit from it.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bettina Gerner, Fatemeh Aghai-Trommeschlaeger, Sabrina Kraus, Goetz Ulrich Grigoleit, Sebastian Zimmermann, Max Kurlbaum, Hartwig Klinker, Nora Isberner, Oliver Scherf-Clavel
Summary: This study developed a PBPK model to investigate the drug-drug interaction between POS and RUX. The research found that when used in combination with POS, RUX exposure increased, suggesting the need for further dose adjustments.
Article
Hematology
Jiapei Liu, Zhiping Fan, Na Xu, Jieyu Ye, Yanqiu Chen, Ruoyang Shao, Yiming Sun, Qiaoyuan Wu, Qifa Liu, Hua Jin
Summary: This study evaluated the effects of ruxolitinib compared with basiliximab in the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD). The results showed that ruxolitinib had a higher overall response rate and effectively prevented chronic GVHD (cGVHD), leading to improved survival rates.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Jiapei Liu, Zhiping Fan, Na Xu, Jieyu Ye, Yanqiu Chen, Ruoyang Shao, Yiming Sun, Qiaoyuan Wu, Qifa Liu, Hua Jin
Summary: This study retrospectively evaluated the effects of ruxolitinib compared with basiliximab for steroid-refractory acute graft-versus-host disease (SR-aGVHD). The results showed that ruxolitinib had higher overall response and complete response rates, as well as lower incidence of chronic GVHD. Ruxolitinib also improved overall survival and failure-free survival rates. In addition, ruxolitinib significantly reduced the occurrence of EBV viremia. Therefore, ruxolitinib should be recommended for the treatment of SR-aGVHD.
ANNALS OF HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tianrong Xun, Yan Rong, Bin Lv, Jinfei Tian, Qing Zhang, Xixiao Yang
Summary: This study aimed to investigate the pharmacokinetic interactions and potential mechanisms between atorvastatin (ATO) and voriconazole (VOR). Results from patient and rat models showed that VOR significantly reduced the metabolism of ATO and slowed the formation of its metabolites. In vitro studies demonstrated that VOR inhibited the metabolism of ATO and testosterone. These findings are important for dose adjustment and the design of rational treatment regimens for fungal infections in patients with dyslipidemia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Hematology
Sameem Abedin, Nahid Rashid, Mark Schroeder, Rizwan Romee, Mary Nauffal, Muhamad Alhaj Moustafa, Mohamed A. Kharfan-Dabaja, Jeanne Palmer, William Hogan, Mehrdad Hefazi, Samantha Larson, Shernan Holtan, Zachariah DeFilipp, Reena Jayani, Bhagirathbhai Dholaria, Joseph Pidala, Farhad Khimani, Michael R. Grunwald, Candace Butler, Mehdi Hamadani
Summary: Among 307 patients with SR-aGVHD, approximately 1/5 of patients showed resistance or intolerance to Ruxolitinib. The overall response rate to additional therapy was 36% in resistant patients with a median survival of 21 days; while 50% of intolerant patients continued to improve with additional therapy, with a median survival of 50 days. These data provide a baseline for future studies on SR-aGVHD.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Chemistry, Medicinal
Cong Wei, Xiaoting Zhang, Dan Liang, Jilong Yang, Jingwen Du, Chunyan Yue, Lan Deng
Summary: Ruxolitinib has been shown to be a safe and effective treatment for steroid-refractory GVHD in a Chinese population, with high overall response rates in acute GVHD patients and comparable overall survival rates between responders and non-responders in chronic GVHD patients. Common adverse events include cytopenia, cytomegalovirus reactivation, and infections, particularly in patients with acute GVHD.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Dong Wang, Yin Liu, Xiaoxuan Lai, Jia Chen, Qiao Cheng, Xiao Ma, Zhihong Lin, Depei Wu, Yang Xu
Summary: The study showed that ruxolitinib is potentially a safe and effective treatment for patients with steroid-refractory chronic GVHD, with an overall response rate of 74.3%. The main adverse event was cytopenia. Treatment with ruxolitinib increased the percentage of CD4 cells, decreased the percentages of NK cells and regulatory T cells, and increased the proportion of total B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Wenli Yang, Guanghua Zhu, Maoquan Qin, Zhigang Li, Bin Wang, Jun Yang, Tianyou Wang
Summary: The study found that Ruxolitinib is effective for acute and chronic graft-versus-host disease in children. Patients with chronic GVHD had a higher overall response rate and better prognosis after treatment compared to those with acute GVHD.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Elisabetta Xue, Francesca Lorentino, Francesca Pavesi, Andrea Assanelli, Jacopo Peccatori, Massimo Bernardi, Consuelo Corti, Fabio Ciceri, Maria Teresa Lupo Stanghellini
Summary: Chronic Graft versus Host Disease (GvHD) is a serious complication of allogeneic hematopoietic stem cell transplant that severely impacts quality of life and long-term survival. Ruxolitinib has been shown to be a safe and effective salvage treatment option for advanced stages of chronic GvHD, with an overall response rate of 59% at three months and 62% at six months. Further prospective analyses on larger cohorts are ongoing to evaluate the durability of response.
Article
Oncology
Nora Isberner, Sabrina Kraus, Goetz Ulrich Grigoleit, Fatemeh Aghai, Max Kurlbaum, Sebastian Zimmermann, Hartwig Klinker, Oliver Scherf-Clavel
Summary: Knowledge on Ruxolitinib exposure in GvHD patients is limited, with this study finding that exposure levels are higher in GvHD patients compared to myelofibrosis patients due to reduced clearance and co-administration with CYP3A4 or CYP2C9 inhibitors. Elevated Ruxolitinib trough concentrations may be an indicator of potential toxicity in patients needing dose reduction due to adverse events.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Surgery
Bin Pan, Longmei Shang, Cong Liu, Jun Gao, Fan Zhang, Mengdi Xu, Lingling Li, Zengtian Sun, Zhenyu Li, Kailin Xu
Summary: The combined therapy of PD-1 antibody and ruxolitinib increased graft-versus-lymphoma effects without increasing acute graft-versus-host disease, leading to improved survival of recipients challenged by A20 lymphoma cells.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Hematology
Rebecca Gonzalez, Eric Gaskill, Maya Padilla, Joseph Pidala, Aleksandr Lazaryan, Lia Perez, Farhad Khimani, Rawan Faramand
Summary: This study investigated the potential effects of BEL on sirolimus and tacrolimus levels when used concurrently. The results showed a significant increase in the concentration-dose ratio of both drugs after the addition of BEL, indicating the need for multiple dosage adjustments. A significant proportion of patients had levels outside the therapeutic range. Dose reductions and close monitoring of drug levels are recommended when adding BEL.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Oncology
Robert Q. Le, Xin Wang, Hongfei Zhang, Hongshan Li, Donna Przepiorka, Jonathon Vallejo, Ruby Leong, Lian Ma, Kirsten B. Goldberg, Richard Pazdur, Marc R. Theoret, Angelo De Claro
Summary: The Food and Drug Administration approved ruxolitinib for the treatment of chronic graft-versus-host disease (cGVHD) after the failure of systemic therapy. Ruxolitinib demonstrated higher response rates and longer duration of response compared to best available therapy (BAT), with manageable adverse reactions.
Article
Medicine, General & Internal
Robert Zeiser, Nicola Polverelli, Ron Ram, Shahrukh K. Hashmi, Ronjon Chakraverty, Jan Moritz Middeke, Maurizio Musso, Sebastian Giebel, Ant Uzay, Peter Langmuir, Norbert Hollaender, Maanasa Gowda, Tommaso Stefanelli, Stephanie J. Lee, Takanori Teshima, Franco Locatelli
Summary: The study suggests that ruxolitinib can significantly improve overall response, failure-free survival, and symptom response in patients with glucocorticoid-refractory or -dependent chronic graft-versus-host disease (GVHD), although it may increase the incidence of thrombocytopenia and anemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)