Review
Obstetrics & Gynecology
Cengiz Cinnioglu, Heather Glessner, Amy Jordan, Sydney Bunshaft
Summary: Noninvasive and minimally invasive preimplantation genetic testing for aneuploidy (PGT-A) has the potential to become the gold standard for embryonic chromosomal screening. The current research focuses on finding a reliable source of DNA without the need for embryo biopsy. Although the general concordance rates of noninvasive and minimally invasive PGT-A are promising, further research is needed before it can be widely used in clinics.
FERTILITY AND STERILITY
(2023)
Review
Endocrinology & Metabolism
Zhuo Liang, Qiuyue Wen, Jingjing Li, Dingyuan Zeng, Pinxiu Huang
Summary: This meta-analysis demonstrates that PGT-A in RPF patients is associated with improved clinical outcomes, including higher IR, CPR, OPR, and LBR values, and lower CMR compared to the IVF/ICSI group. These findings support the positive clinical application of PGT-A in RPF patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
S. J. Bhatt, N. M. Marchetto, J. Roy, S. S. Morelli, P. G. McGovern
Summary: The study found that preimplantation genetic testing for aneuploidy (PGT-A) was associated with improved live birth rates in patients with recurrent pregnancy loss (RPL) undergoing frozen embryo transfer (IVF-FET).
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
D. C. Kieslinger, C. G. Vergouw, L. Ramos, B. Arends, M. hj m Curfs, E. Slappendel, E. H. Kostelijk, M. H. E. C. Pieters, D. Consten, M. O. Verhoeven, D. E. Besselink, F. Broekmans, B. J. Cohlen, J. M. J. Smeenk, S. Mastenbroek, C. H. de Koning, Y. M. van Kasteren, E. Moll, J. van Disseldorp, E. A. Brinkhuis, Ea m Kuijper, W. M. van Baal, H. G. van Weering, P. J. Q. van der Linden, M. H. Gerards, P. M. Bossuyt, M. van Wely, C. B. Lambalk
Summary: Time-lapse monitoring does not improve clinical outcomes compared with routine methods, casting doubts on its widespread application in fertility treatments.
Article
Obstetrics & Gynecology
Chenxi Li, Yujie Dang, Jing Li, Hongchang Li, Yueting Zhu, Yingying Qin
Summary: The study suggests that preimplantation genetic testing (PGT) is not necessary for women with X chromosome abnormalities (XCAs) in the absence of other indications. XCAs are common chromosomal aberrations in infertile women, with Turner Syndrome patients having low pregnancy rates and high chances of birth defects.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Qingqing Guo, Peihao Liu, Wei Zhou, Mingdi Xia, Jing Li, Juanjuan Lu, Jin-Long Ma, Zi-Jiang Chen, Junhao Yan
Summary: GH supplementation can reduce embryonic aneuploidy and improve pregnancy outcomes in women with previous pregnancy failures and high aneuploidy rates, especially in those younger than 40 years.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Dana Kimelman, Mary Ellen Pavone
Summary: The high incidence of chromosome aneuploidy in human gametes and embryos is a major factor in IVF failure and miscarriage, leading to an increased use of PGT-A. However, PGT-A is a screening method and cannot definitively predict the chromosomal status of embryos and fetuses.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Yunqiao Dong, Dun Liu, Yangyun Zou, Cheng Wan, Chuangqi Chen, Mei Dong, Yuqiang Huang, Cuiyu Huang, Huinan Weng, Xiulan Zhu, Fang Wang, Shujing Jiao, Na Liu, Sijia Lu, Xiqian Zhang, Fenghua Liu
Summary: In this study, a quantitative method, qPCT, was established to detect parental DNA contamination in conventional IVF. It was found that the maternal contamination rate was 0.83% and the risk of paternal contamination was negligible. The clinical study also showed successful pregnancies using vitrified conventional IVF embryos.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Health Care Sciences & Services
Amer Mahmoud Sindiani, Faheem Zayed, Eman Hussein Alshdaifat, Hasan Rawashdeh, Wesam Al-Woshah, Nada Zayed
Summary: The study found that 83.2% of couples undergoing non-medical PGD for male sex selection had a higher ratio of female embryos compared to male embryos. There was no significant difference in patient-related factors between equal and unequal embryonic groups. Patients with positive pregnancy outcomes and those treated with a short protocol were more likely to have an unequal embryonic ratio.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Obstetrics & Gynecology
Jose Bellver, Pedro Brandao, Lucia Alegre, Marcos Meseguer
Summary: This study found no significant differences in embryo development, blastocyst formation rate, and blastocyst morphology between obese women and normal weight women undergoing IVF. This suggests that female obesity does not impact blastocyst formation and embryo morphokinetics, and the poorer IVF outcomes described for obese women may be due to deficient endometrial receptivity.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
R. Sainte-Rose, C. Petit, L. Dijols, C. Frapsauce, F. Guerif
Summary: The study found that blastocyst development rate is significantly reduced in advanced maternal age patients, with blastocysts showing growth retardation on day 5. While cell organization is unaffected by age, blastocysts with 'good' morphology in AMA patients have decreased implantation probability compared to 'average' morphology blastocysts in younger women. Although extended embryo culture is not harmful for AMA patients, it cannot compensate for the reduced implantation and live birth rates associated with maternal age.
SCIENTIFIC REPORTS
(2021)
Review
Obstetrics & Gynecology
Luis Navarro-Sanchez, Carmen Garcia-Pascual, Carmen Rubio, Carlos Simon
Summary: Aneuploidy is common among preimplantation human embryos used in assisted reproductive technology, and current testing methods involve invasive biopsy. However, emerging evidence suggests that embryos secrete cell-free DNA into their culture medium, indicating the potential for a non-invasive assay for aneuploidy. Embryonic cell-free DNA analysis shows high concordance with current methods and can help prioritize blastocysts for transfer, increasing implantation rates and reducing miscarriage rates and time to achieve pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biology
Martin W. Breuss, Xiaoxu Yang, Valentina Stanley, Jennifer McEvoy-Venneri, Xin Xu, Arlene J. Morales, Joseph G. Gleeson
Summary: This study found that in vitro fertilization can lead to the transmission of mutations from males with gonadal mosaicism to embryos. Unbiased preimplantation genetic testing has the potential to reduce the transmission of harmful de novo mutations.
Review
Chemistry, Multidisciplinary
Iza Sazanita Isa, Umi Kalsom Yusof, Murizah Mohd Zain
Summary: The development of intelligence-based methods and application systems has expanded the use of quality blastocyst selection in IVF. In this study, the state-of-the-art in ART is established using an automated deep learning approach, and the scoping review introduces a novel notion in automated blastocyst grading utilizing deep learning applications. These automated methods can match or even outperform skilled embryologists in certain deep learning tasks.
APPLIED SCIENCES-BASEL
(2023)
Article
Obstetrics & Gynecology
Giulia Fiorentino, Danilo Cimadomo, Federica Innocenti, Daria Soscia, Alberto Vaiarelli, Filippo Maria Ubaldi, Gianluca Gennarelli, Silvia Garagna, Laura Rienzi, Maurizio Zuccotti
Summary: This review summarizes the contribution of ovarian morphology and function to follicle recruitment, growth, ovulation, and oocyte developmental competence. It provides important insights into the regulation of follicle recruitment and growth, and suggests strategies for improving follicular recruitment and oocyte competence in clinical practice.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Endocrinology & Metabolism
R. Mazzilli, S. Medenica, A. M. Di Tommaso, G. Fabozzi, V. Zamponi, D. Cimadomo, L. Rienzi, F. M. Ubaldi, M. Watanabe, A. Faggiano, S. La Vignera, G. Defeudis
Summary: This article provides an overview of the impact of impaired thyroid function on male and female fertility. In females, thyroid dysfunction is detrimental to pregnancy and fetal outcomes, and the reference range of TSH has recently become a topic of debate. The impact of thyroid function on the male reproductive system is still unclear, but it may play a role in modulating Sertoli and Leydig cells function and spermatogenesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Editorial Material
Obstetrics & Gynecology
Juan J. Fraire-Zamora, Munevver Serdarogullari, Kashish Sharma, Omar Farhan Ammar, Mina Mincheva, Nick Macklon, Aida Pujol, Antonio Capalbo, Marcos Meseguer, George Liperis
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Kenji Ezoe, Tetsuya Miki, Hikari Akaike, Kiyoe Shimazaki, Tsubasa Takahashi, Yuko Tanimura, Ayumi Amagai, Ayano Sawado, Mai Mogi, Shigeru Kaneko, Satoshi Ueno, Giovanni Coticchio, Danilo Cimadomo, Andrea Borini, Laura Rienzi, Keiichi Kato
Summary: Maternal ageing significantly affects pronuclear size and intra-and extra-nuclear dynamics during fertilization, dysregulates cell polarity during compaction, and reduces blastocoel expansion.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Alberto Vaiarelli, Danilo Cimadomo, Carlotta Scarafia, Federica Innocenti, Maria Giulia Amendola, Gemma Fabozzi, Livio Casarini, Alessandro Conforti, Carlo Alviggi, Gianluca Gennarelli, Chiara Benedetto, Maurizio Guido, Andrea Borini, Laura Rienzi, Filippo Maria Ubaldi
Summary: This study aimed to explore the impact of different gonadotrophin selection for ovarian stimulation on oocyte competence. The results showed that the choice of recombinant FSH or human menopausal gonadotrophin for ovarian stimulation was associated with the euploid blastocyst rate. However, there was no association between the type of gonadotrophin used and live birth rate or blastocyst quality.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Endocrinology & Metabolism
R. Mazzilli, C. Rucci, A. Vaiarelli, D. Cimadomo, F. M. Ubaldi, C. Foresta, A. Ferlin
Summary: This article reviews the impact of the male factor on assisted reproductive technology (ART) and provides an overview of the indications, minimum access criteria, and outcomes of ART techniques in relation to male factor.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Cristiano Scandurra, Alfonso Maria Di Tommaso, Danilo Cimadomo, Rocky Strollo, Antongiulio Faggiano, Silvia Migliaccio, Nicola Napoli
Summary: The purpose of this study was to evaluate the relationships between health literacy, unrealistic optimism, and adherence to glycometabolic disease management related to erectile dysfunction (ED) in male patients with type 2 diabetes (T2D) or preDM. The results showed a close relationship between health literacy, unrealistic optimism, and treatment adherence.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Obstetrics & Gynecology
Filippo Maria Ubaldi, Alberto Vaiarelli, Danilo Cimadomo, Maria Cerrillo, Laura Rienzi, Juan A. Garcia-Velasco
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Giovanni Coticchio, Danilo Cimadomo, Greta Chiara Cermisoni, Laura Rienzi, Enrico Papaleo, Filippo Maria Ubaldi, Andrea Borini, Lucia De Santis
Summary: Human embryos are often affected by maternally inherited aneuploidies, leading to developmental failure at early stages. Recent evidence shows that aberrant patterns at the cellular or molecular level can impact multiple stages of embryo development. Fertilization is a delicate phase where centrosomes are assembled and nuclei undergo crucial changes. Errors in this process can result in cellular or genomic integrity loss and fatal consequences for embryonic development.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Danilo Cimadomo, Viviana Chiappetta, Federica Innocenti, Gaia Saturno, Marilena Taggi, Anabella Marconetto, Valentina Casciani, Laura Albricci, Roberta Maggiulli, Giovanni Coticchio, Aisling Ahlstrom, Jorgen Berntsen, Mark Larman, Andrea Borini, Alberto Vaiarelli, Filippo Maria Ubaldi, Laura Rienzi
Summary: Preimplantation genetic testing for aneuploidies (PGT-A) is an effective embryo selection strategy, but it has limitations. The iDAScore v1.0 model, based on artificial intelligence, can objectively evaluate embryo quality and competence. It shows promising performance in predicting embryo morphology and live-birth outcomes, potentially improving embryologists' evaluations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
A. Ahlstroem, K. Lundin, D. Cimadomo, G. Coticchio, U. Selleskog, G. Westlander, J. Winerdal, C. Stenfelt, S. Callender, C. Nyberg, M. Astroem, K. Loefdahl, L. Nolte, M. Sundler, M. Kitlinski, I. Liljeqvist Soltic, T. Bohlin, J. Baumgart, K. E. Lindgren, F. Guelen Yaldir, L. Rienzi, A. K. Lind, C. Bergh
Summary: This Swedish study investigated whether embryo culture in a closed time-lapse system is associated with any differences in perinatal and maternal outcomes compared to conventional culture and spontaneous conceptions. The study found no significant differences between time-lapse and conventional incubation systems in terms of preterm birth, low birth weight, and hypertensive disorders of pregnancy. However, singletons born from time-lapse incubation had a higher risk of preterm birth and low birth weight compared to singletons from spontaneous conceptions.
HUMAN REPRODUCTION
(2023)
Editorial Material
Obstetrics & Gynecology
Munevver Serdarogullari, George Liperis, Kashish Sharma, Omar F. Ammar, Julia Uraji, Danilo Cimadomo, Alessandra Alteri, Mina Popovic, Juan J. Fraire-Zamora
HUMAN REPRODUCTION
(2023)
Review
Physiology
Inmaculada Moreno, Antonio Capalbo, Aymara Mas, Tamara Garrido-Gomez, Beatriz Roson, Maurizio Poli, Eva Dimitriadis, Xavier Santamaria, Felipe Vilella, Carlos Simon
Summary: Pregnancy is established during the periconceptional period from blastocyst attachment to placenta formation, significantly impacting the health of both the child and the mother. Advances in understanding the periconceptional space, including the preimplantation human embryo and maternal endometrium, offer opportunities for preventative interventions. This review discusses the role of maternal decidua, the maternal-embryonic interface, the endometrial microbiome, and the myometrium in pregnancy health during the periconceptional period.
PHYSIOLOGICAL REVIEWS
(2023)
Review
Health Care Sciences & Services
Stefano Canosa, Alberto Revelli, Gianluca Gennarelli, Gennaro Cormio, Vera Loizzi, Francesca Arezzo, Easter Anna Petracca, Andrea Roberto Carosso, Danilo Cimadomo, Laura Rienzi, Alberto Vaiarelli, Filippo Maria Ubaldi, Erica Silvestris
Summary: Recent advances in anticancer treatment have greatly improved the survival rate of young females, but one third of cancer survivors still face the risk of ovarian insufficiency and infertility. Several procedures have been developed to preserve fertility, including ovarian surgical transposition, gonadotropin-releasing hormone agonists (GnRH-a) treatment, and oocyte and/or ovarian cortical tissue cryopreservation. Innovative techniques, such as the construction of an artificial ovary and the use of stem cells for neo-folliculogenesis and oocyte development, are under investigation. These techniques offer potential strategies for oncofertility programs and provide hope for young female cancer survivors.
Article
Obstetrics & Gynecology
D. Cimadomo, M. J. de los Santos, G. Griesinger, G. Lainas, N. Le Clef, D. J. McLernon, D. Montjean, B. Toth, N. Vermeulen, N. Macklon
Summary: This article provides the first ESHRE good practice recommendations for defining and managing recurrent implantation failure (RIF) in patients undergoing ART. RIF is a challenge in the ART clinic, with numerous investigations and interventions offered and applied without clear biological rationale or evidence of benefit. The recommendations include investigating causes and contributing factors of RIF, as well as improving the chances of a successful pregnancy.
HUMAN REPRODUCTION OPEN
(2023)