Antioxidant compounds from the stem bark of Garcinia atroviridis

A new xanthone, namely garcinexanthone G (1), along with eight known compounds, stigmasta-5,22-dien-3-ol (2), stigmasta-5,22-dien-3-O--glucopyranoside (3), 3-acetoxy-11,12-epoxyoleanan-28,13-olide (4), 2,6-dimethoxy-p-benzoquinone (5), 1,3,5-trihydroxy-2-methoxyxanthone (6), 1,3,7-trihydroxyxanthone (7), kaempferol (8) and quercetin (9), were isolated from the stem bark of Garcinia atroviridis. Their structures were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR, and mass spectrometry. All the isolated compounds were evaluated for their antioxidant properties based on the DPPH radical scavenging activities. Results showed that 1,3,7-trihydroxyxanthone and quercetin showed significant antioxidant activities with EC50 values of 16.20 and 12.68g/ml, respectively, as compared to the control, ascorbic acid (7.4 mu g/ml).