Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 19, Issue 5, Pages 519-527Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2016.1234456
Keywords
Bupleurum chinense; lignans; antioxidant activities; cytotoxicities; structural elucidation
Funding
- National Natural Sciences Foundation of China [81130071]
- Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education
- Foundation from the Project of Innovation Team [LT2015027]
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In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8-O-4 neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2-9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and cytotoxic effects of isolated compounds were evaluated in vitro. The isolated compounds (IC50>200M) did not display 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Whereas compounds 1-2, 5, 7, and 9 exhibited potent 2, 2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging properties with IC50 values ranging from 8.34 to 15.24M, while compounds 3-4, 6, 8 showed moderate properties. In addition, all compounds were evaluated for cytotoxicities against A549, HepG2, U251, Bcap-37, and MCF-7 cell lines. Compounds 5 and 9 (IC50<51.62M) possessed stronger cytotoxic activities against all the tested tumor cell lines, compared with the positive control 5-Fluorouracil.
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