Article
Pharmacology & Pharmacy
Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao
Summary: The study found that Phlorizin (PHZ) has positive effects on fatigue, as it can alleviate fatigue and improve exercise endurance. PHZ achieves these effects by reducing reactive oxygen species, enhancing antioxidant enzyme activity, and regulating apoptosis-related factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samir A. Salama, Mohamed S. Abdel-Bakky, Alaa A. Mohamed
Summary: This study investigated the protective effects of the natural alkaloid leonurine against iron-induced hepatotoxicity in rats. The results showed that leonurine suppressed ferroptosis, oxidative damage, and inflammation in the liver tissues. It also enhanced the antioxidant potential and improved histopathological abnormalities. Mechanistically, leonurine modulated the Nrf2 and NF-kappa B signaling pathways. These findings highlight the hepatoprotective activity of leonurine against iron-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Ran Xiao, Yu Wei, Yueping Zhang, Fan Xu, Congjian Ma, Qihai Gong, Jianmei Gao, Yingshu Xu
Summary: The study demonstrates that trilobatin alleviates exhaustive exercise-induced fatigue (EEIF) by reducing oxidative stress through the Nrf2/ARE/ferroptosis axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuanghua Liu, Zhaopeng Zhou, Pu Ai, Chunlei Zhang, Junhui Chen, Yuhai Wang
Summary: This study demonstrates the significant role of ferroptosis in subarachnoid hemorrhage and reveals that Astragaloside IV inhibits ferroptosis by activating the Nrf2/HO-1 pathway, providing neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Review
Medicine, Research & Experimental
Marjan Talebi, Mohammad Mehdi Sadoughi, Seyed Abdulmajid Ayatollahi, Elaheh Ainy, Roghayeh Kiani, Alireza Zali, Mirmohammad Miri
Summary: CBD, a non-psychoactive cannabinoid, has been found to have numerous therapeutic benefits and is closely associated with the Nrf2 signaling pathway. Nrf2 is linked to various health issues including cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Understanding the relationship between CBD and Nrf2 is of great interest in the medical field and could significantly impact the treatment and prevention of a wide range of health conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Gastroenterology & Hepatology
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti
Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Changshun Yang, Yu Zhang, Shengtao Lin, Yi Liu, Weihua Li
Summary: The study found that inhibiting the KIF20A/NUAK1/ PP1 beta/GPX4 pathway can reverse the resistance of colorectal cancer cells to oxaliplatin.
Article
Food Science & Technology
Lin-Feng Tang, Xiaoming Ma, Li-Wei Xie, Hao Zhou, Jiahua Yu, Zhen-Xin Wang, Ming Li
Summary: This study demonstrates that perillaldehyde (PAH) has radioprotective effects on radiation-induced intestinal injury by inhibiting ferroptosis through activating Nrf2 signaling pathway. PAH treatment prolongs survival time, promotes survival of crypt cells, attenuates radiation-induced DNA damage, and mitigates intestinal barrier damage. These findings suggest that PAH could be a potential therapeutic strategy for radiation-induced intestinal injury.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Chemistry, Medicinal
Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Gaurav Mishra, Selen Ilgun, Saeed Samarghandian
Summary: Nrf2 plays a crucial role in various diseases, and green tea catechins as a source of phenolic compounds can address a wide range of clinical issues. Green tea catechins, especially EGCG, elucidate the protective role of Nrf2 and its downstream molecules in various disorders, showing significant potential in managing and protecting against different diseases.
PHYTOTHERAPY RESEARCH
(2021)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Article
Biotechnology & Applied Microbiology
Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang
Summary: This study found that Mirt2 plays an important role in regulating lipid metabolism in macrophages by inhibiting MAPK signaling and activating the NRF2 signaling pathway.