Article
Medicine, Research & Experimental
Kun Zhang, Tao Zhang, Yuhan Yang, Wenling Tu, Hongbin Huang, Yujun Wang, Yuzhuo Chen, Kejian Pan, Zhuojia Chen
Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.
Article
Pathology
Min Li, Shengbai Sun, Zehua Bian, Surui Yao, Meng Liu, Xiaohong You
Summary: Long noncoding RNAs (lncRNAs) have a significant role in tumor progression, including colorectal cancer (CRC). This study focused on the lncRNA SNHG15 and its involvement in glycolysis and chemoresistance in CRC. The analysis of CRC tissues showed that SNHG15 was upregulated and its overexpression enhanced cell proliferation, chemoresistance to 5-fluorouracil (5-FU), and glycolysis. Additionally, multiple pathways, including apoptosis, were potentially regulated by SNHG15. These findings suggest that SNHG15 could be a novel therapeutic target for CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Junxing Qu, Zhiheng Sun, Chen Peng, Daoqian Li, Wenyue Yan, Zhen Xu, Yayi Hou, Sunan Shen, Ping Chen, Tingting Wang
Summary: Candida tropicalis has been found to promote chemotherapy resistance in colon cancer by producing lactate and inhibiting the expression of MLH1, providing a new insight into improving the efficacy of colorectal cancer chemotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Han Xu, Longzhi Li, Bing Dong, Ji Lu, Kun Zhou, Xiaoxing Yin, Huizhen Sun
Summary: The study reveals that TRAF6 overexpression in triple-negative breast cancer (TNBC) promotes chemoresistance to paclitaxel by regulating glycolysis through direct binding to PKM2. The findings suggest that TRAF6 could serve as a potential molecular target for TNBC treatment.
Article
Food Science & Technology
Lei Huang, Canxia He, Sicong Zheng, Chao Wu, Minghua Ren, Yujuan Shan
Summary: Sulforaphane (SFN) reduces ATP production in bladder cancer cells by inhibiting glycolysis and mitochondrial oxidative phosphorylation. SFN weakens glycolytic flux by suppressing metabolic enzymes such as hexokinase 2 (HK2) and pyruvate dehydrogenase (PDH). Additionally, SFN downregulates the unique glucose transport aberrant-independent aerobic glycolysis in bladder cancer through the AKT1/HK2 axis and PDH expression.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sun Young Park, Ye Seo Chung, So Yeon Park, So Hee Kim
Summary: Resistance to oxaliplatin in colorectal cancer cells is associated with increased phosphorylation of AMPK, leading to cell survival. Inhibition of AMPK can induce autophagy and restore chemosensitivity to anticancer drugs.
Review
Environmental Sciences
Ali G. Alkhathami, Ameer S. Sahib, Majed Saad Al Fayi, Ali Abdulhussain Fadhil, Mohammed Abed Jawad, Sahar Ahmad Shafik, Safwan Jassim Sultan, Abbas F. Almulla, Min Shen
Summary: The metabolism of cancer is characterized by a shift from mitochondrial oxidative phosphorylation to glucose metabolism known as glycolysis. Glycolysis, its molecular profile, related pathways, and enzymes such as hexokinase have been well-understood. Inhibition of glycolysis can significantly reduce tumorigenesis. Meanwhile, circRNAs, a type of non-coding RNA, have a unique covalently closed loop structure and have gained attention recently for their potential role as biomarkers in cancer due to their stability. CircRNAs regulate various molecular mechanisms, including glycolysis, and can influence tumor progression by modulating enzymes involved in glycolysis like hexokinase. Induction of glycolysis by circRNAs can enhance cancer cell proliferation and metastasis, and circRNAs' impact on malignancy and drug resistance can influence cancer treatment outcomes. Downstream targets of circRNAs, such as TRIM44, CDCA3, SKA2, and ROCK1, play a role in regulating glycolysis in cancer. Additionally, microRNAs are key regulators of glycolysis in cancer cells and are influenced by circRNAs which act as upstream mediators. Furthermore, nanoparticles have emerged as promising tools in cancer therapy, including the delivery of circRNAs, and targeting glycolysis and cancer cells through stimuli-responsive and ligand-functionalized nanoparticles can inhibit carcinogenesis.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Mei-Qian Wang, Yi-Ru Chen, Hui-Wen Xu, Jia-Rong Zhan, Da-Qin Suo, Ji-Jin Wang, Yuan-Zhen Ma, Xin-Yuan Guan, Yan Li, Sen-Lin Zhu
Summary: There is increasing evidence that HKDC1, a hexokinase domain containing protein-1, plays a critical role in promoting glycolysis, tumorigenesis, and epithelial-mesenchymal transition (EMT) in gastric cancer (GC). High expression of HKDC1 is associated with worse prognosis and chemoresistance in GC patients. The activation of the NF-kappa B pathway is involved in the oncogenic and metastatic function of HKDC1.
Article
Cell Biology
Huan Wang, Lie Wang, Haiyan Pan, Yaona Wang, Miao Shi, Hang Yu, Chaoye Wang, Xinfu Pan, Zhijun Chen
Summary: This study reveals that M2 macrophages induce chemoresistance in lung cancer through the release of MDE, with key involvement of miR-3679-5p and the NEDD4L/c-Myc signaling cascade. These findings not only present a potential new therapeutic target, but also shed light on the crosstalk mechanisms between macrophages and lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wesam F. F. Farrash, Akhmed Aslam, Riyad Almaimani, Faisal Minshawi, Hussain Almasmoum, Aiman Alsaegh, Mohammad S. S. Iqbal, Aisha Tabassum, Mohamed E. E. Elzubier, Mahmoud Z. Z. El-Readi, Amani A. A. Mahbub, Shakir Idris, Bassem Refaat
Summary: This study investigated the effects of 5-fluorouracil (5-FU), metformin (Met), and/or thymoquinone (TQ) single/dual/triple therapies on colon cancer cell lines. The triple therapy showed the highest pro-apoptotic actions and the best suppression of the PI3K/mTOR/HIF1 alpha pathway. The triple therapy also exhibited the highest increases in oxidative stress markers and the lowest antioxidant levels in all cell lines.
Article
Cell Biology
Kanghua Xiao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong, Siting Chen, Guangyao Liu, Hong Li, Jian Huang, Xu Chen, Tianxin Lin
Summary: This study reveals that UBE2S interacts with TRIM21 to degrade LPP through K11-linked ubiquitination, promoting lymphatic metastasis of bladder cancer (BCa). Targeting UBE2S with cephalomannine inhibits BCa progression in vitro and in vivo without significant toxicity, suggesting UBE2S as a potent therapeutic target for metastatic BCa.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Chang Liu, Changfeng Li, Yuanda Liu
Summary: Pancreatic cancer is a highly malignant disease with hidden onset and early metastasis. Chemotherapy is the primary treatment, but chemoresistance has become an urgent clinical problem. Recent studies have shown that metabolic reprogramming, including glucose, lipid, and amino acid metabolism, plays a crucial role in tumorigenesis and drug tolerance. Additionally, mitochondria, as central players in nutrient and energy metabolism, are also involved in drug resistance development. This review summarizes the metabolic changes during pancreatic cancer progression, their impact on chemoresistance, and current studies on metabolic inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mahrou Vahabi, Annalisa Comandatore, Marika A. Franczak, Ryszard T. Smolenski, Godefridus J. Peters, Luca Morelli, Elisa Giovannetti
Summary: Exosomes play a crucial role in intercellular communication and can influence cancer cell behavior and response to treatment. They can transport glycolytic enzymes, leading to altered glucose metabolism and increased tumor progression, survival, immune evasion, and drug resistance. Understanding exosome-mediated cell-to-cell communication may open new therapeutic avenues and facilitate biomarker development, and combining exosome-based-targeted therapies with existing treatments holds promise in overcoming resistance and improving cancer treatment outcomes.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Cell Biology
Yu-Chan Chang, Ming-Hsien Chan, Chien-Hsiu Li, Chih-Jen Yang, Yu-Wen Tseng, Hsing-Fang Tsai, Jean Chiou, Michael Hsiao
Summary: Phosphoglycerate kinase (PGK) plays a crucial role in tumorigenesis, especially PGK1 which is associated with metastasis and negatively correlated with survival rate. The study found a significant increase of PGK1 in adenocarcinoma, and suggested a functional control of cancer metastasis by PGK1 binding to HTATSF1. Additionally, a nonenzymatic function of PGK1 was also demonstrated.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Yuki Teramoto, Guiyang Jiang, Takuro Goto, Taichi Mizushima, Yujiro Nagata, George J. Netto, Hiroshi Miyamoto
Summary: In bladder cancer cells, GULP1 is regulated by AR signaling and influences sensitivity to cisplatin. Knockdown of GULP1 results in increased resistance to cisplatin treatment, reduced apoptosis, and increased G2/M phases. Additionally, GULP1 expression levels correlate with response to neoadjuvant chemotherapy in muscle-invasive bladder cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
