Article
Endocrinology & Metabolism
Yi-Ju Chen, Kang-Yung Peng, Jeff S. Chueh, Hung-Wei Liao, Tsung-Yi Hsieh, Vin-Cent Wu, Shuo-Meng Wang
Summary: This study reported a PA patient with concomitant ACS, showing that bilateral APM may coexist with histopathologically classical and non-classical PA adenomas with different somatic mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Peripheral Vascular Disease
Ute Scholl
Summary: Primary aldosteronism is the most common cause of secondary hypertension, largely due to genetic mutations in ion channels and pumps. Somatic mutations are responsible for sporadic cases, while germline mutations cause familial hyperaldosteronism.
Article
Endocrinology & Metabolism
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study aimed to explore the role of two confirmatory tests in the subtype diagnosis of primary aldosteronism (PA). The results showed that patients with discordant results between confirmatory tests are highly likely to have a bilateral subtype on adrenal vein sampling (AVS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Peripheral Vascular Disease
Gian Paolo Rossi, Domenico Bagordo, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent Wu, Zuzana Kratka, Michele Battistel, Giacomo Rossitto, Teresa Maria Seccia
Summary: This study investigates whether selectively unilateral adrenal vein sampling can identify the responsible adrenal gland.
Article
Peripheral Vascular Disease
Jacopo Burrello, Martina Tetti, Vittorio Forestiero, Vanessa Biemmi, Sara Bolis, Margherita Alba Carlotta Pomatto, Martina Amongero, Dario Di Silvestre, Pierluigi Mauri, Giuseppe Vassalli, Giovanni Camussi, Tracy Ann Williams, Paolo Mulatero, Lucio Barile, Silvia Monticone
Summary: EVs were found to potentially act as biomarkers of vascular inflammation and endothelial dysfunction in patients with PA. Specific EV surface signature could differentiate patients with PA from controls, and after PA treatment the profile became similar to patients with essential hypertension.
Review
Peripheral Vascular Disease
Viola Sanga, Giacomo Rossitto, Teresa Maria Seccia, Gian Paolo Rossi
Summary: This study aims to diagnose primary aldosteronism in pregnancy (PAP) and provide management suggestions based on the evidence obtained. A nomogram was developed to identify PAP cases based on the changes in aldosterone and renin. PAP cases were classified into four groups with different management and outcomes. Adrenalectomy did not improve maternal and fetal outcomes compared to medical treatment alone. Early detection and surgical treatment of unilateral PAP resulted in better outcomes for maternal hypertension and mother and baby outcomes.
Review
Biochemistry & Molecular Biology
Izabela Karwacka, Lukasz Obolonczyk, Sonia Kaniuka-Jakubowska, Michal Bohdan, Krzysztof Sworczak
Summary: Primary aldosteronism is a group of disorders caused by the autonomous overproduction of aldosterone, most commonly due to bilateral adrenal hyperplasia or aldosterone-producing adenoma. Recent progress in understanding the genetic basis of PA has identified ion channel mutations as a major cause of aldosterone-producing adenomas, with several genes implicated in both sporadic and familial cases. These new insights into the molecular mechanisms underlying PA may have implications for diagnosis and therapy.
Article
Genetics & Heredity
Juilee Rege, Sascha Bandulik, Kazutaka Nanba, Carla Kosmann, Amy R. Blinder, Allein Plain, Pankaj Vats, Chandan Kumar-Sinha, Antonio M. Lerario, Tobias Else, Yuto Yamazaki, Fumitoshi Satoh, Hironobu Sasano, Thomas J. Giordano, Tracy Ann Williams, Martin Reincke, Adina F. Turcu, Aaron M. Udager, Richard Warth, William E. Rainey
Summary: This study identified mutations in the SLC30A1 gene associated with PA. The mutations are located near the zinc-binding site in the coding region of SLC30A1 and may cause abnormal ion transport. PA cases with SLC30A1 mutations showed male dominance and increased levels of aldosterone and 18-oxocortisol.
Article
Medicine, General & Internal
Renata Libianto, Grant M. Russell, Michael Stowasser, Stella M. Gwini, Peta Nuttall, Jimmy Shen, Morag J. Young, Peter J. Fuller, Jun Yang
Summary: This study aimed to assess the ability of general practitioners (GPs) in screening and diagnosing primary aldosteronism (PA) in newly diagnosed, treatment-naive patients with hypertension. Screening was done by measuring aldosterone-to-renin ratio (ARR), and PA diagnosis was confirmed through saline suppression testing. The results showed that PA was diagnosed in 14% of patients with newly diagnosed hypertension screened by GPs.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Kohei Saito, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Koichi Yamamoto, Masanobu Yamada, Kohei Kamemura, Yuichi Fujii, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study revealed significant changes in the clinical characteristics of primary aldosteronism subtypes APA and BAH from 2006 to 2018. APA patients tended to be diagnosed earlier and in milder forms, while BAH patients showed decreases in hypertension duration and hypokalemia prevalence.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Lucie S. Meyer, Laura Handgriff, Jung Soo Lim, Aaron M. Udager, Isabella-Sabrina Kinker, Roland Ladurner, Moritz Wildgruber, Thomas Knoesel, Martin Bidlingmaier, William E. Rainey, Martin Reincke, Tracy Ann Williams
Summary: In surgically treated patients with unilateral primary aldosteronism, there are differences in histopathology, genotype, and postsurgical outcomes between classical and nonclassical groups. Patients with nonclassical histopathology have a higher incidence of postsurgical disease persistence and increased aldosterone production from the unresected gland.
Article
Endocrinology & Metabolism
Vin-Cent Wu, Kang-Yung Peng, Ya-Hui Hu, Chin-Chen Chang, Chieh-Kai Chan, Tai-Shuan Lai, Yen-Hung Lin, Shuo-Meng Wang, Ching-Chu Lu, Yu-Chun Liu, Yao-Chou Tsai, Jeff S. Chueh
Summary: Elevated pACE2 concentrations and increased expression of TMPRSS2 mRNA are observed in patients with primary aldosteronism (PA) and essential hypertension (EH). After hypertension remission following adrenalectomy, pACE2 levels decrease. Persistently elevated pACE2 is associated with increased risk of mortality and cardiovascular events.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Satoshi Ugi, Maya Yonishi, Daisuke Sato, Nobuhiko Nakaizumi, Osamu Horikawa, Yukihiro Fujita, Kentaro Inoue, Akinori Wada, Susumu Kageyama, Akihiro Kawauchi, Michiko Hino, Mai Noujima, Yuto Yamazaki, Hironobu Sasano, Hiroshi Maegawa
Summary: This is a case of a patient referred for hypertension and a right adrenal tumor, who was later found to have coexistent PA and pheochromocytoma. Histology of the resected adrenal gland confirmed the presence of multiple aldosterone-producing micronodules. Following surgery, urinary catecholamine levels normalized, hyperaldosteronism improved but persisted, and hypertension normalized with spironolactone.
Article
Endocrinology & Metabolism
Seung Hun Lee, Jong Woo Kim, Hyun-Ki Yoon, Jung-Min Koh, Chan Soo Shin, Sang Wan Kim, Jung Hee Kim
Summary: This retrospective study of 466 PA patients found that patients with hypokalemia, PAC >30.0 ng/dL, and a unilateral lesion were at high risk of unilateral PA regardless of age.
ENDOCRINOLOGY AND METABOLISM
(2021)