Article
Immunology
Rebekah M. Dedrick, Bailey E. Smith, Madison Cristinziano, Krista G. Freeman, Deborah Jacobs-Sera, Yvonne Belessis, A. Whitney Brown, Keira A. Cohen, Rebecca M. Davidson, David van Duin, Andrew Gainey, Cristina Berastegui Garcia, C. R. Robert George, Ghady Haidar, Winnie Ip, Jonathan Iredell, Ameneh Khatami, Jessica S. Little, Kirsi Malmivaara, Brendan J. McMullan, David E. Michalik, Andrea Moscatelli, Jerry A. Nick, Maria G. Tupayachi Ortiz, Hari M. Polenakovik, Paul D. Robinson, Mikael Skurnik, Daniel A. Solomon, James Soothill, Helen Spencer, Peter Wark, Austen Worth, Robert T. Schooley, Constance A. Benson, Graham F. Hatfull
Summary: Bacteriophage therapy shows potential as an adjunctive treatment for nontuberculous Mycobacterium infections. This study observed no adverse reactions, favorable outcomes in at least 50% of patients, and no evidence of phage resistance.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Computer Science, Interdisciplinary Applications
Maria Victoria Diaz-Galian, Miguel A. Vega-Rodriguez, Felipe Molina
Summary: Phage therapy is a strategy used to lyse bacteria that cause harm to health. This article introduces an R package called PhageCocktail that automatically designs efficient phage cocktails.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jose Luis Villalpando-Aguilar, Gilberto Matos-Pech, Itzel Lopez-Rosas, Hugo Gildardo Castelan-Sanchez, Fulgencio Alatorre-Cobos
Summary: Phage therapy is an alternative treatment that uses bacteriophages to kill specific bacteria. It has shown positive results in improving food production in agriculture. However, finding effective bacteriophages is crucial for the success of this therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Greater Kayode Oyejobi, Xiaoxu Zhang, Dongyan Xiong, Faith Ogolla, Heng Xue, Hongping Wei
Summary: Phage treatment shows potential for bacterial infections, but bacterial resistance to phage is a challenge. Research on phage resistance and coevolutionary dynamics between phage and bacteria is crucial for successful phage therapy.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Immunology
Hadil Onallah, Ronen Hazan, Ran Nir-Paz
Summary: The use of bacteriophages as a treatment for antibiotic-resistant infections is gaining interest, and the Israeli Phage Therapy Center has shown promising results with favorable clinical outcomes in 77.7% of cases. The center has received a growing number of requests for phage therapy, particularly for multidrug-resistant bacterial infections.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Save, Yok-Ai Que, Jose M. Entenza, Camille Kolenda, Frederic Laurent, Gregory Resch
Summary: This study evaluated the potential of phage therapy for the treatment of Staphylococcus aureus infections and found that combining phages with a low-dose antibiotic could be a promising strategy for the treatment of S. aureus infective endocarditis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Immunology
Khashayar Shahin, Lili Zhang, Mohammad Hossein Mehraban, Jean-Marc Collard, Abolghasem Hedayatkhah, Mojtaba Mansoorianfar, Abbas Soleimani-Delfan, Ran Wang
Summary: This article provides a comprehensive review/perspective of the potential applications of bacteriophages in combating the COVID-19 pandemic and the post-COVID era. It discusses the use of bacteriophages for treatment, vaccine development, and virus detection techniques, highlighting their potential for ecological and epidemiological modeling.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Payel Mondal, Prolay Halder, Bani Mallick, Subhadip Bhaumik, Hemanta Koley, Shanta Dutta, Moumita Dutta
Summary: This study evaluated the efficacy of Salmonella phage STWB21 in reducing the burden of salmonellosis in a mammalian host by inhibiting Salmonella Typhi invasion into the liver and spleen tissue. The results showed that phage treatment significantly improved the survival percentage of infected mice and could control tissue inflammation before and after Salmonella infection. To the best of our knowledge, this is the first report of phage therapy in a mouse model against a clinically isolated Salmonella Typhi strain with direct visualization of histopathology and ultrathin section microscopy images from the liver and spleen sections.
Article
Virology
Jonathan Save, Yok-Ai Que, Jose Entenza, Gregory Resch
Summary: In this study, the efficacy of a combination therapy of bacteriophages and vancomycin was investigated in a rat model of MRSA infective endocarditis. The results showed that the phage cocktail alone was not able to control bacterial growth, but when combined with subtherapeutic doses of vancomycin, a significant decrease in bacterial load was observed. However, the administration of vancomycin significantly affected the local concentrations of phages in the vegetation and organs.
Article
Immunology
Josef Prazak, Luca G. Valente, Manuela Iten, Lea Federer, Denis Grandgirard, Sara Soto, Gregory Resch, Stephen L. Leib, Stephan M. Jakob, Matthias Haenggi, David R. Cameron, Yok-Ai Que
Summary: Aerosolized phage therapy showed potential for treating MRSA pneumonia in an experimental animal model, reducing bacterial loads and lung damage. When combined with systemically applied phages, more than 90% of animals were rescued from lethal infection, highlighting the promise of nebulized bacteriophages for pneumonia treatment.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Oncology
Steven I. Hajdu
Summary: The period from 1962 to 1977 witnessed significant advancements in the field of oncology, including the discovery of antigens, introduction of imaging technologies, improvement in treatment methods, and standardization of cancer staging classification. Clinical trials played a crucial role in proving the effectiveness of certain therapies, paving the way for further developments in oncology.
Editorial Material
Infectious Diseases
Andrzej Grzybowski, Maciej Zaczek, Andrzej Gorski, Beata Weber-Dabrowska, Ryszard Miedzybrodzki
Summary: Bronislawa Brandla Fejgin was a Polish-born Jewish female physician who focused on phage research in microbiology. Despite not being as famous as Western European phage pioneers, her contributions to the field deserve recognition. Her publications in French on phages provide valuable information on early attempts at therapeutic use in humans.
Review
Microbiology
Amit Rimon, Daniel Gelman, Ortal Yerushalmy, Shunit Coppenhagen-Glazer, Eyal Katvan, Ran Nir-Paz, Ronen Hazan
Summary: This study focuses on the history of phage therapy in Mandatory-Palestine and Israel, highlighting the treatments conducted and the efforts made in present-day Israel.
PHAGE-THERAPY APPLICATIONS AND RESEARCH
(2022)
Review
Microbiology
Luigi Marongiu, Markus Burkard, Ulrich M. Lauer, Ludwig E. Hoelzle, Sascha Venturelli
Summary: Phage therapy has advantages over antibiotics in the treatment of bacterial infections, but early clinical trials' results were doubted, limiting its adoption in Western countries. A recent study reevaluated early 20th-century studies and found phage therapy to be effective, but less effective than standard treatments.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Engineering, Electrical & Electronic
Przemyslaw Sadlowski, Piotr Rataj, Jerzy Hickiewicz
Summary: The article presents the activities of the Association of Polish Electrical Engineers (SEP) in 1925-1926, including the General Meetings of SEP Delegates and the formation of the Polish Electrotechnical Committee. It provides a brief history of these events and highlights the important issues discussed during this period.
PRZEGLAD ELEKTROTECHNICZNY
(2023)
Article
Environmental Sciences
Agnieszka Wincek, Juliusz Huber, Katarzyna Leszczynska, Wojciech Fortuna, Stefan Okurowski, Pawel Tabakow
Summary: Comparative neurophysiological tests were conducted to evaluate the range of functional regeneration in patients with thoracic incomplete spinal cord injury (iSCI) after long-term kinesiotherapy. The results showed moderate improvement in motor function but no improvement in sensory function.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Anna Zyman, Andrzej Gorski, Ryszard Miedzybrodzki
Summary: Phages are viruses that can specifically infect and destroy bacteria, showing potential for eradicating wound-associated infections. Phage therapy may be an effective treatment with advantages over current antibacterial treatments, minimizing bacterial resistance and demonstrating synergism with antibiotics. However, further research is needed to determine the optimal dosage and promote phage therapy in modern medicine.
FOLIA MICROBIOLOGICA
(2022)
Article
Infectious Diseases
Andrzej Gorski, Jan Borysowski, Ryszard Miedzybrodzki
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Review
Infectious Diseases
Jan Kowalski, Renata Gorska, Martyna Cieslik, Andrzej Gorski, Ewa Jonczyk-Matysiak
Summary: Periodontitis, a serious medical and social problem, can lead to tooth loss and contribute to the development of various diseases. The search for and isolation of bacteriophages specific to the bacteria causing periodontitis is seen as a great opportunity to address persistent colonization by bacterial pathogens and reduce the use of antibiotics to limit antibiotic resistance.
Article
Virology
Martyna Cieslik, Marek Harhala, Filip Orwat, Krystyna Dabrowska, Andrzej Gorski, Ewa Jonczyk-Matysiak
Summary: In this study, two newly isolated myoviruses that can lyse multidrug-resistant Enterobacter spp. were characterized. These phages belong to a poorly represented phage group and show potential for therapeutic use against urinary tract infections.
Article
Infectious Diseases
Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Pawel Rogoz, Beata Weber-Dabrowska, Maciej Zaczek, Andrzej Gorski
Summary: Phage therapy may induce an immune response and production of neutralizing antibodies. The presence of these antibodies can affect the success of therapy, but it does not necessarily guarantee failure. On the other hand, phage-antibody complexes may cause tissue damage and late complications, highlighting the importance of monitoring antibody levels and discontinuing therapy if necessary.
Article
Virology
Natalia Baginska, Marek Adam Harhala, Martyna Cieslik, Filip Orwat, Beata Weber-Dabrowska, Krystyna Dabrowska, Andrzej Gorski, Ewa Jonczyk-Matysiak
Summary: Infections with multi-drug resistant Acinetobacter baumannii pose a serious threat. Phage therapy is a promising alternative for treating these infections. This study isolated and characterized 12 phages specific for A. baumannii, providing valuable tools for fighting against this pathogen and boosting interest in phage therapy as an alternative to antibiotics.
Article
Pharmacology & Pharmacy
Beata Weber-Dabrowska, Maciej Zaczek, Malgorzata Lobocka, Marzanna Lusiak-Szelachowska, Barbara Owczarek, Filip Orwat, Norbert Lodej, Aneta Skaradzinska, Lukasz Laczmanski, Dariusz Martynowski, Marta Kaszowska, Andrzej Gorski
Summary: In recent years, multidrug-resistant strains of Klebsiella pneumoniae have become a global concern and bacteriophage therapy may provide a potential solution. This study evaluated the properties and effectiveness of bacteriophages against Klebsiella strains, identifying promising candidates for therapeutic purposes. Additionally, historical phages were examined, including one with lytic activity that has been maintained for nearly 60 years.
Article
Clinical Neurology
Maria Podbielska, Jozefa Macala, Anna Jakubiak-Augustyn, Zdzislaw M. Szulc, Wojciech Fortuna, Slawomir Budrewicz, Ewa Jaskiewicz, Malgorzata Bilinska, Edward L. Hogan, Anna Pokryszko-Dragan
Summary: This study investigated the levels of anti-ceramide immunoglobulins G (IgGs) in cerebrospinal fluid (CSF) and serum of different phenotypes of multiple sclerosis (MS) patients, as well as their relationship with MS-related variables. The results showed that MS patients had higher levels of anti-C16:0, C18:0, C18:1, C24:0, and C24:1 ceramide IgGs in both CSF and serum compared to controls. The levels of specific anti-ceramide IgGs correlated between CSF and serum, as well as with the Link index. There were differences in serum and CSF anti-ceramide IgGs between patients with clinically isolated syndrome (CIS) and relapsing-remitting MS compared to progressive MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Marta Piksa, Wojciech Fortuna, Cheng Lian, Malgorzata Gacka, Ifor D. W. Samuel, Katarzyna Matczyszyn, Krzysztof J. Pawlik
Summary: We evaluated the efficacy of antimicrobial Photodynamic Therapy (APDT) using organic light-emitting diodes (OLED) for antibiotic-resistant clinical strains from diabetic foot ulcers. The isolated strains from diabetic foot ulcers were identified and tested for antibiotic susceptibility. APDT using OLED as a light source and methylene blue as a photosensitizer effectively reduced pathogens and opportunistic bacteria regardless of drug resistance.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Adam Jedrusiak, Wojciech Fortuna, Joanna Majewska, Andrzej Gorski, Ewa Jonczyk-Matysiak
Summary: This review focuses on the influence of bacteriophages on the central nervous system. It explores the link between bacteriophages in the gut microbiota and the gut-brain axis network, as well as their potential therapeutic applications in treating brain and neural diseases.
Article
Biochemistry & Molecular Biology
Paulina Sliwka, Beata Weber-Dabrowska, Maciej Zaczek, Marta Kuzminska-Bajor, Izabela Dusza, Aneta Skaradzinska
Summary: This study characterized three bacteriophages (BF9, BF15, and BF17) with lytic activity against ESBLs- and AmpC-producing E. coli. Comparative genomic and phylogenetic analysis identified these phages as belonging to the Dhillonvirus, Tequatrovirus, and Asteriusvirus genera, respectively. The phages inhibited bacterial growth and retained their lytic ability at a wide range of temperatures (-20-40 degrees C) and pH values (5-9). The absence of toxin genes and bacterial virulence factors in BF9, BF15, and BF17 further supports their potential for future phage applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Wojciech Fortuna, Benita Wiatrak, Paulina Jawien, Adriana Kubis-kubiak, Ying LI, Daqing LI, Pawel Tabakow
Summary: This study aimed to test methods of culturing OECs with materials and reagents certified for pharmaceutical use. The study found that using acid-solubilized collagen for suspending OECs in collagen gel is better than pepsin-solubilized collagen, and OEC cultures should be grown on surfaces modified with fibronectin.
