Journal
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volume 77, Issue 7-8, Pages 343-350Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/znc-2021-0298
Keywords
apoptosis; curcumin; cytotoxicity; necrosis; silver nanoparticles
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Silver nanoparticles synthesized using curcumin showed promising anticancer activity against DLD-1 and A549 cells, but had minimal effect on L929 cells. The nanoparticles induced apoptosis in the cancer cells, making them a potential candidate for anticancer drug development.
Nanostructures have distinctive chemical and physical features owing to their surface area and nanoscale size. In this study, silver nanoparticles were synthesized using curcumin, a medicinally valuable natural product. The structure of curcumin-mediated silver nanoparticles (c-AgNPs) was identified by extensive spectroscopic techniques. The maximum absorption was observed at 430 nm in UV-Vis spectrum. The crystal structure of c-AgNPs was identified by XRD. The morphology of the structure was determined by SEM image. The particle size was found as 51.13 nm. The functional groups of curcumin and c-AgNPs were established by FTIR spectroscopy. Cytotoxic activity of c-AgNPs was carried out using A549, DLD-1, and L929 with MTT assay. c-AgNPs revealed excellent activity on DLD-1 cell lines and A549 cell lines at 1.0 mg/mL concentration with the lethal effect of 80%. However, nanoparticles did not show the considerable effect on L929. Moreover, they induced apoptosis. Consequently, c-AgNPs are a promising material for anticancer drugs candidate.
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