Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 250, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.vetimm.2022.110444
Keywords
Bovine mastitis; Klebsiella; Taurine; Necroptosis; RIPK1; RIPK3; MLKL pathway
Categories
Funding
- special projects for Local Science and Technology Development [2019L3011]
- Natural Science Foundation of Fujian Province of China [2021J011099]
- Innovation and entrepreneurship carrier service improvement project of Longyan high tech Zone [2020 (21)]
Ask authors/readers for more resources
This study investigates the inflammatory damage caused by Klebsiella infection. The results demonstrate that necroptosis induced by Klebsiella infection can be partially reversed by taurine and Nec-1s, leading to reduced production of inflammatory cytokines.
Klebsiella infection is widely acknowledged to inflict severe inflammatory damage in bovines. Herein, we demonstrate significant death of EpH4-Ev cells incubated with Klebsiella. And compelling evidence shows that Klebsiella infection increases interactions between the Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3, which promotes phosphorylation of RIPK3 and MLKL to induce necroptosis. However, these changes can be partially reversed by taurine and Nec-1s. Moreover, using taurine and Nec-1s to partially inhibit necroptosis significantly reduce TNF-alpha, IL-1 beta and IL-6 levels and NAGase activity induced by Klebsiella infection. Taken together, taurine partially inhibits necroptosis induced by Klebsiella infection and hence alleviates inflammatory and injury in EpH4-Ev cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available