Article
Urology & Nephrology
Michal Rejchrt, Jan Krhut, Marcel Gartner, Bertil F. M. Blok, Peter Zvara
Summary: The study aimed to evaluate the persistence of treatment effect achieved during the initial course of peroneal electrical Transcutaneous NeuroModulation (peroneal -eTNM((R))) in patients with overactive bladder (OAB). The results showed that 48% of patients continued to experience the treatment effect after 12 months of the initial course of peroneal -eTNM((R)). Rating: 7 points.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Medicine, General & Internal
Zhi-Hong Wang, Zhi-Hong Liu
Summary: This study aimed to compare the efficacy and safety of parasacral neuromodulation (PNS) and tibial nerve stimulation (TNS) for patients with overactive bladder (OAB). The results showed that both types of neuromodulation had similar effects in terms of micturition, urgency episodes, incontinence episodes, and nocturia episodes, as well as similar questionnaire scores. Additionally, no adverse events were reported in either group.
Article
Obstetrics & Gynecology
Jan Krhut, Michal Rejchrt, Martin Slovak, Roman Dvorak, Michal Grepl, Peter Zvara
Summary: This study evaluated the efficacy and safety of peroneal electrical transcutaneous neuromodulation as a home treatment for refractory overactive bladder. The results showed that peroneal eTNM was highly effective, with a therapeutic response in approximately 80% of patients, and had a good safety profile.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Jan Krhut, Michal Rejchrt, Martin Slovak, Roman V. Dvorak, Lukas Peter, Bertil F. M. Blok, Peter Zvara
Summary: In this study, peroneal electrical transcutaneous neuromodulation was shown to be a safe and effective method for treating overactive bladder, with a significantly lower incidence of treatment-related adverse events and a better benefit-risk profile compared to solifenacin.
JOURNAL OF UROLOGY
(2023)
Article
Engineering, Biomedical
Alice Wang, Elizabeth Rourke, Elisabeth Sebesta, Roger Dmochowski
Summary: Overactive bladder and urge urinary incontinence affect millions of people and result in substantial healthcare costs. Concerns over side effects of common medications have led to increased interest in sacral neuromodulation as a potential therapy. The Axonics System is considered safe and effective for treating these conditions, with the added convenience of being rechargeable and MRI safe.
EXPERT REVIEW OF MEDICAL DEVICES
(2021)
Review
Medicine, General & Internal
Peng Liu, Yan Li, Benkang Shi, Qiujie Zhang, Hu Guo
Summary: This study compares the efficacy and safety of different interventions for treating idiopathic overactive bladder. The results show that antimuscarinics, mirabegron, Onabotulinumtoxin A, sacral neuromodulation, and peripheral tibial nerve stimulation are all more effective than placebo, with sacral neuromodulation and Onabotulinumtoxin A showing the best results.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, Research & Experimental
Ioan Scarneciu, Sorin Lupu, Ovidiu Gabriel Bratu, Andreea Teodorescu, Laurian Stefan Maxim, Adrian Brinza, Alexandru Georgian Laculiceanu, Ruxandra Maria Rotaru, Aura-Mihaela Lupu, Camelia Cornelia Scarneciu
Summary: Overactive bladder syndrome is a chronic and disabling condition that significantly affects the quality of life of millions of patients worldwide. Establishing a correct diagnosis and implementing effective individualized treatment are crucial in managing this challenging condition. Improved collaboration and understanding with patients are essential in achieving favorable outcomes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Urology & Nephrology
Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, Chikara Ohyama
Summary: The study found that individuals reporting daily urinary urgency had lower bacterial diversity in their gut microbiome, lower abundance of Bifidobacterium, and higher abundance of Faecalibacterium compared to non-OAB individuals.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Engineering, Biomedical
Morgan J. Bressington, David Scholtz, Ali Hooshiary, Wikus Vermeulen, Timothy Burns, Flavio Ordones, Peter Gilling
Summary: Peripheral nerve stimulation, specifically the eCoin device, has shown promise in managing refractory overactive bladder symptoms. Early data suggests efficacy and low complication rates, but further research and long-term data are needed to establish its role in long-term management.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Review
Medicine, General & Internal
Nurida Khasanah, Hung-Yen Chin, Chih-Wei Peng
Summary: Almost one-fifth of the global population experiences a decrease in quality of life due to overactive bladder (OAB) syndrome. Current treatments include reducing fluid intake, pelvic floor muscle training, and antimuscarinic drugs, but refractory cases still occur. Physical agent-based treatments, such as neuromodulation, have become an important option in third-line therapy for OAB, offering effectiveness and minimal side effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Peter Gilling, Patrick Meffan, Bilal Kaaki, Scott MacDiarmid, Vincent Lucente, Matthew Clark, Subhro K. Sen, Sharon English, Peter K. Sand
Summary: The eCoin is a safe and effective treatment for urgency urinary incontinence associated with overactive bladder syndrome, with significant reduction or complete resolution of symptoms and no significant safety concerns.
Article
Neurosciences
Maria Alejandra Gonzalez-Gonzalez, Kevin Romero, John Beitter, David Lloyd, Danny V. Lam, Ana Guadalupe Hernandez-Reynoso, Aswini Kanneganti, Han-Kyul Kim, Caroline K. Bjune, Scott Smith, Wanpen Vongpatanasin, Mario I. Romero-Ortega
Summary: Hypertension affects a large number of adults in the United States, and despite effective pharmacological treatments, a significant percentage of patients have uncontrolled blood pressure. This study investigated the use of deep peroneal nerve stimulation (DPNS) as a possible strategy to lower blood pressure in drug-resistant hypertension. The results suggest that DPNS consistently reduces blood pressure and alters renal sympathetic nerve activity. A novel wireless system was developed to test the acute effect of DPNS in awake animals, confirming its ability to lower blood pressure. These findings support the use of DPN neuromodulation as a potential approach to manage drug-resistant hypertension.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Urology & Nephrology
Manon te Dorsthorst, Michael van Balken, Dick Janssen, John Heesakkers, Frank Martens
Summary: This study evaluated the long-term real-life adherence of transcutaneous tibial nerve stimulation (TTNS) in the treatment of OAB, finding that although effective in the short-term, it is not effective in the long-term. Reasons for quitting therapy included loss of effect and preference for other types of neuromodulation. There is a need for improvement in OAB treatment modalities due to low patient satisfaction.
THERAPEUTIC ADVANCES IN UROLOGY
(2021)
Article
Obstetrics & Gynecology
Bilal Kaaki, Sharon English, Peter Gilling, Patrick Meffan, Vincent Lucente, Scott MacDiarmid, Matthew Clark, Subhro K. Sen
Summary: This study evaluated the feasibility, safety, and efficacy of eCoin reimplantation for the treatment of refractory urgency urinary incontinence (UUI) associated with overactive bladder syndrome. The results demonstrated that eCoin reimplantation was both safe and effective, with a significant reduction or resolution of symptoms.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2022)
Article
Medicine, General & Internal
Naoko Izumi, Tomohiro Matsuo, Yoshihisa Matsukawa
Summary: This study investigated the association between physician-patient communication and patient satisfaction with overactive bladder (OAB) medical care, as well as clinical effectiveness. The findings suggest that adequate physician-patient communication significantly contributes to improving clinical effectiveness and satisfaction with medical care in OAB patients, thereby increasing treatment continuation.
JOURNAL OF CLINICAL MEDICINE
(2022)